1-[(4aS,6R,7R,7aS)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-7-(tert-butyl-dimethyl-silanyloxy)-dihydro-furo[3,2-d][1,3]dioxin-4a-yl]-5-methyl-1H-pyrimidine-2,4-dione | 219537-84-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 1-[(4aS,6R,7R,7aS)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-7-(tert-butyl-dimethyl-silanyloxy)-dihydro-furo[3,2-d][1,3]dioxin-4a-yl]-5-methyl-1H-pyrimidine-2,4-dione
• CAS: 219537-84-5
• 化学式: C₃₉H₄₈N₂O₉Si
• 分子量: 716.904
• InChiKey: BEIIAJUOUONVSA-MOJVCKTQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.69
• 重原子数：
  51.0
• 可旋转键数：
  11.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  119.47
• 氢给体数：
  1.0
• 氢受体数：
  10.0

反应信息

• 作为反应物：
  描述：

  1-[(4aS,6R,7R,7aS)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-7-(tert-butyl-dimethyl-silanyloxy)-dihydro-furo[3,2-d][1,3]dioxin-4a-yl]-5-methyl-1H-pyrimidine-2,4-dione 在 吡啶 、 1H-1,2,4-三唑 、 ammonium hydroxide 、 四丁基氟化铵 、 溶剂黄146 、 三乙胺 、 三氯氧磷 作用下， 以 四氢呋喃 为溶剂， 生成
  参考文献：
  名称：

  Synthesis and hybridization property of an oligonucleotide analog containing A 1′,3′-DI-O-methylene-α-D-fructose backbone

  摘要：

  Hydrogen phosphonate monomers of T (thymine) and C-m (5-methylcytosine) bearing a 1',3'-di-O-methylene-alpha-D-fructose sugar moiety were synthesized and incorporated into an oligonucleotide. Hybridization studies by thermal denaturation experiment indicated that this oligonucleotide did not form a duplex with the complementary RNA target. (C) 1998 Elsevier Science Ltd. Ail rights reserved.

  DOI：

  10.1016/s0960-894x(98)00566-6
• 作为产物：
  描述：

  ((4aS,6R,7R,7aS)-7-(benzoyloxy)-4a-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydro-4H-furo[3,2-d][1,3]dioxin-6-yl)methyl benzoate 在 吡啶 、 咪唑 、 sodium methylate 作用下， 以 甲醇 为溶剂， 生成 1-[(4aS,6R,7R,7aS)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-7-(tert-butyl-dimethyl-silanyloxy)-dihydro-furo[3,2-d][1,3]dioxin-4a-yl]-5-methyl-1H-pyrimidine-2,4-dione
  参考文献：
  名称：

  Synthesis and hybridization property of an oligonucleotide analog containing A 1′,3′-DI-O-methylene-α-D-fructose backbone

  摘要：

  Hydrogen phosphonate monomers of T (thymine) and C-m (5-methylcytosine) bearing a 1',3'-di-O-methylene-alpha-D-fructose sugar moiety were synthesized and incorporated into an oligonucleotide. Hybridization studies by thermal denaturation experiment indicated that this oligonucleotide did not form a duplex with the complementary RNA target. (C) 1998 Elsevier Science Ltd. Ail rights reserved.

  DOI：

  10.1016/s0960-894x(98)00566-6