2-aminophenoxathiin | 10350-07-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: 2-aminophenoxathiin
• 英文别名: 2-aminophenoxathiine；2-Aminophenoxatiin；phenoxathiin-2-ylamine；2-Phenoxathiinamine；phenoxathiin-2-amine
• CAS: 10350-07-9
• 化学式: C₁₂H₉NOS
• 分子量: 215.276
• InChiKey: PTJUVPGWNLXDFK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  60.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-aminophenoxathiin 在 sodium hypochlorite 、 溶剂黄146 、 苯 作用下， 生成 N-(10-oxo-10λ⁴-phenoxathiin-2-yl)-acetamide
  参考文献：
  名称：

  Nitration of Phenoxathiin and Some New Amino Derivatives¹

  摘要：

  DOI：

  10.1021/ja01110a025
• 作为产物：
  描述：

  N-phenoxathiin-2-yl-acetamide 在 盐酸 作用下， 生成 2-aminophenoxathiin
  参考文献：
  名称：

  Nitration of Phenoxathiin and Some New Amino Derivatives¹

  摘要：

  DOI：

  10.1021/ja01110a025

文献信息

• Process for production of vinyl chloride polymer
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：EP0172427A2

  公开（公告）日：1986-02-26

  This process is a process for production of a vinyl chloride polymer by suspension polymerization or emulsion polymerization of vinyl chloride monomer or a mixture of vinyl chloride monomer with a vinyl monomer copolymerizable with said vinyl chloride monomer in an aqueous medium, characterized in that the polymerization is carried out in a polymerizer, the inner wall surface and portions of the auxiliary equipment thereof which may come into contact with the monomer during polymerization being previously coated with a scaling preventive comprising at least one selected from dyes, pigments and aromatic or heterocyclic compounds having at least 5 conjugated π bonds, while controlling the chloride ion concentration in the reaction mixture to not higher than 100 ppm. According to said process, scaling onto the inner wall surface of a polymerizer, etc. during polymerization can be prevented effectively and surely.

  该工艺是通过氯乙烯单体或氯乙烯单体与可与所述氯乙烯单体共聚的乙烯基单体混合物在水介质中进行悬浮聚合或乳液聚合来生产氯乙烯聚合物的工艺，其特征在于聚合是在聚合器中进行的、内壁表面及其辅助设备中可能在聚合过程中与单体接触的部分事先涂上一层防垢剂，该防垢剂至少包括一种选自染料、颜料和至少有 5 个共轭 π 键的芳香族或杂环化合物的防垢剂，同时控制反应混合物中的氯离子浓度不高于 100 ppm。根据上述工艺，可有效、可靠地防止聚合过程中聚合器等内壁表面结垢。
• ORGANIC LIGHT-EMITTING DEVICE
  申请人：Samsung Display Co., Ltd.

  公开号：EP3133661A1

  公开（公告）日：2017-02-22

  An organic light-emitting device comprises: a first electrode; a second electrode; and an organic layer between the first electrode and the second electrode , the organic layer comprising an emission layer and a hole transport region, wherein the hole transport region is between the first electrode and the emission layer, and the hole transport region comprises a first compound represented by Formula 1 and a second compound represented by Formula 2:

  一种有机发光器件包括：第一电极；第二电极；以及位于第一电极和第二电极之间的有机层，有机层包括发射层和空穴传输区域，其中空穴传输区域位于第一电极和发射层之间，空穴传输区域包括由式 1 表示的第一化合物和由式 2 表示的第二化合物：
• Baciu, Ion; Cîrlanaru, Carmen; Ionitǎ, Gabriela, Revue Roumaine de Chimie, 2001, vol. 46, # 6, p. 633 - 636
  作者：Baciu, Ion、Cîrlanaru, Carmen、Ionitǎ, Gabriela、Drǎghici, Constantin

  DOI：——

  日期：——
• The antifungal activity of sulfonylamido derivatives of 2-aminophenoxathiin and related compounds
  作者：Claudiu T. Supuran、Andrea Scozzafava、Fabrizio Briganti、George Loloiu、Ovidiu Maior

  DOI：10.1016/s0223-5234(99)80034-8

  日期：1998.10

  Aryl/alkyl-sulfonylamido, arylsulfenylamido, arylcarboxamido and ureido/thioureido derivatives of 2-aminophenoxathiin were prepared by reaction of the title compound with sulfonyl/sulfenyl halides, sulfonic acid anhydrides, acyl chlorides, tosyl isocyanate, aryl/allyl isocyanates or isothiocyanates. Some of these derivatives, containing free amino groups, have been further derivatized by reaction with 2,4,6-trisubstituted-pyrylium salts, aryl/allyl isocyanate/isothiocyanates or tosyl isocyanate. Several of the newly synthesized compounds act as effective antifungal agents against Aspergillus and Candida spp., some of them showing activities comparable to ketoconazole or itraconazole (against the aspergilli) but being much less effective against Candida. The mechanism of action of these compounds involves inhibition of ergosterol biosynthesis, and probably interaction with lanosterol-14-alpha-demethylase (CYP51A1), since reduced amounts of ergosterol were evidenced by means of HPLC in cultures of the sensitive strain A. niger treated with some of these inhibitors. Thus, the two classes of antifungal compounds, i.e. the azoles and the new derivatives reported here, might possess a similar mechanism of action at molecular level. (C) Elsevier, Paris.
• Irie, Rikagaku Kenkyusho Iho, 1941, vol. 20, p. 150,152 Anm.
  作者：Irie

  DOI：——

  日期：——