N-(5-ethynylpyridin-3-yl)acetamide

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-(5-ethynylpyridin-3-yl)acetamide
• 英文别名: N-(5-Ethynylpyridin-3-yl)acetamide
• 化学式: C₉H₈N₂O
• 分子量: 160.175
• InChiKey: HDABVEDPHZIOJY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  42
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(5-ethynylpyridin-3-yl)acetamide 在 copper(l) iodide 、 四甲基乙二胺 作用下， 以 二氯甲烷 为溶剂， 以94%的产率得到N,N'-(buta-1,3-diyne-1,4-diylbis(pyridine-5,3-diyl))diacetamide
  参考文献：
  名称：

  Fjord-Edge Graphene Nanoribbons with Site-Specific Nitrogen Substitution

  摘要：

  The synthesis of graphene nanoribbons (GNRs) that contain site-specifically substituted backbone heteroatoms is one of the essential goals that must be achieved in order to control the electronic properties of these next generation organic materials. We have exploited our recently reported solid-state topochemical polymerization/cyclization-aromatization strategy to convert the simple 1,4-bis(3-pyridyl)butadiynes 3a,b into the fjord-edge nitrogen-doped graphene nanoribbon structures 1a,b (fjord-edge N-2[8]GNRs). Structural assignments are confirmed by CP/MAS C-13 NMR, Raman, and XPS spectroscopy. The fjord-edge N2[8]GNRs 1a,b are promising precursors for the novel backbone nitrogen-substituted N-2[8](A)GNRs 2a,b. Geometry and band calculations on N-2[8](A)GNR 2c indicate that this class of nanoribbons should have unusual bonding topology and metallicity.

  DOI：

  10.1021/jacs.0c07657
• 作为产物：
  描述：

  5-溴-3-氨基吡啶 在 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 、 potassium carbonate 、 三乙胺 、 二异丙胺 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 甲苯 为溶剂， 生成 N-(5-ethynylpyridin-3-yl)acetamide
  参考文献：
  名称：

  Fjord-Edge Graphene Nanoribbons with Site-Specific Nitrogen Substitution

  摘要：

  The synthesis of graphene nanoribbons (GNRs) that contain site-specifically substituted backbone heteroatoms is one of the essential goals that must be achieved in order to control the electronic properties of these next generation organic materials. We have exploited our recently reported solid-state topochemical polymerization/cyclization-aromatization strategy to convert the simple 1,4-bis(3-pyridyl)butadiynes 3a,b into the fjord-edge nitrogen-doped graphene nanoribbon structures 1a,b (fjord-edge N-2[8]GNRs). Structural assignments are confirmed by CP/MAS C-13 NMR, Raman, and XPS spectroscopy. The fjord-edge N2[8]GNRs 1a,b are promising precursors for the novel backbone nitrogen-substituted N-2[8](A)GNRs 2a,b. Geometry and band calculations on N-2[8](A)GNR 2c indicate that this class of nanoribbons should have unusual bonding topology and metallicity.

  DOI：

  10.1021/jacs.0c07657

文献信息

• FUSED RING COMPOUND CONTAINING FURAN OR SALT THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING SAME
  申请人：YUHAN CORPORATION

  公开号：US20150191478A1

  公开（公告）日：2015-07-09

  The present invention provides a fused ring compound containing furan or a pharmaceutically acceptable salt thereof, a method for preparing same, a pharmaceutical composition comprising same, and a use thereof. The fused ring compound containing furan or a pharmaceutically acceptable salt thereof inhibits the activity of phosphatidylinositol 3-kinase (PI3K) and can therefore be used in a pharmaceutical composition for treating and preventing respiratory diseases, inflammatory diseases, proliferative diseases, cardiovascular diseases, or central nervous system diseases which occur due to the over-activation of PI3K.

  本发明提供一种含有呋喃或其药用可接受盐的融环化合物，以及制备该化合物的方法、包含该化合物的药物组合物和其用途。含有呋喃或其药用可接受盐的融环化合物抑制磷脂酰肌醇3-激酶（PI3K）的活性，因此可用于制备治疗和预防由于PI3K过度活化而引起的呼吸道疾病、炎症性疾病、增殖性疾病、心血管疾病或中枢神经系统疾病的药物组合物。
• EP2876109
  申请人：——

  公开号：——

  公开（公告）日：——
• US9493478B2
  申请人：——

  公开号：US9493478B2

  公开（公告）日：2016-11-15
• Fjord-Edge Graphene Nanoribbons with Site-Specific Nitrogen Substitution
  作者：Yolanda L. Li、Chih-Te Zee、Janice B. Lin、Victoria M. Basile、Mit Muni、Maria D. Flores、Julen Munárriz、Richard B. Kaner、Anastassia N. Alexandrova、K. N. Houk、Sarah H. Tolbert、Yves Rubin

  DOI：10.1021/jacs.0c07657

  日期：2020.10.21

  The synthesis of graphene nanoribbons (GNRs) that contain site-specifically substituted backbone heteroatoms is one of the essential goals that must be achieved in order to control the electronic properties of these next generation organic materials. We have exploited our recently reported solid-state topochemical polymerization/cyclization-aromatization strategy to convert the simple 1,4-bis(3-pyridyl)butadiynes 3a,b into the fjord-edge nitrogen-doped graphene nanoribbon structures 1a,b (fjord-edge N-2[8]GNRs). Structural assignments are confirmed by CP/MAS C-13 NMR, Raman, and XPS spectroscopy. The fjord-edge N2[8]GNRs 1a,b are promising precursors for the novel backbone nitrogen-substituted N-2[8](A)GNRs 2a,b. Geometry and band calculations on N-2[8](A)GNR 2c indicate that this class of nanoribbons should have unusual bonding topology and metallicity.