caffeine theophylline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: caffeine theophylline
• 英文别名: Caffeine:Theophylline cocrystal；1,3-dimethyl-7H-purine-2,6-dione;1,3,7-trimethylpurine-2,6-dione
• 化学式: C₇H₈N₄O₂*C₈H₁₀N₄O₂
• 分子量: 374.359
• InChiKey: FDGAASMEUKCILR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.07
• 重原子数：
  27
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  128
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  茶碱 、 咖啡因 以 1,4-二氧六环 、 N,N-二甲基甲酰胺 为溶剂， 生成 caffeine theophylline
  参考文献：
  名称：

  Cocrystal dissociation and molecular demixing in the solid state

  摘要：

  研究发现，一种含有咖啡因和茶碱的新型共晶体在加热时会发生解离，咖啡因和茶碱分子会自发地解离并重新结晶为独立的相，这种固-固转变可能是由熵增加驱动的。透射电子显微镜测定了所产生晶体的形态和成分。

  DOI：

  10.1039/c2cc33412g

文献信息

• [EN] COMPOUNDS FOR THE TREATMENT OF MYOTONIC DYSTROPHY<br/>[FR] COMPOSÉS POUR LE TRAITEMENT DE LA DYSTROPHIE MYOTONIQUE
  申请人：UNI DE VALÈNCIA

  公开号：WO2016075285A1

  公开（公告）日：2016-05-19

  The present invention relates to a compound of formula (I), provided that this compound is not caffeine, for use in the treatment of myotonic dystrophy type 1 and type 2. The present invention also relates to compositions comprising the compound of formula (I). The present invention further relates to new compounds which are dimers of compounds of formula (I).

  本发明涉及一种式（I）的化合物，前提是该化合物不是咖啡因，用于治疗肌张力性疾病类型1和类型2。本发明还涉及包含该式（I）化合物的组合物。本发明还涉及新的化合物，这些化合物是式（I）化合物的二聚体。
• Method, system and devices for the assay and detection of biochemical molecules
  申请人：SOLARCARE TECHNOLOGIES CORPORATION

  公开号：EP0330517A2

  公开（公告）日：1989-08-30

  Oxygen-independent methods, systems and devices for the enzymatic colorimetric assay and detection of biochemical analytes. Two systems are described, both of which produce less than one equivalent of dye per equivalent of substrate, maintaining dye concentrations in the range where Beer's law predicts a linear color-concentration relationship. One system produces an analog color signal from an analog analyte input, the other system produces a digital color signal from an analog analyte input.

  用于酶比色测定和检测生化分析物的不依赖氧气的方法、系统和装置。本文介绍了两种系统，这两种系统每产生一个当量的底物所产生的染料都少于一个当量，从而将染料浓度保持在比尔定律所预测的颜色-浓度线性关系的范围内。一个系统通过模拟分析物输入产生模拟颜色信号，另一个系统通过模拟分析物输入产生数字颜色信号。
• COMPOUNDS FOR THE TREATMENT OF MYOTONIC DYSTROPHY
  申请人：Universitat de València

  公开号：EP3217985A1

  公开（公告）日：2017-09-20
• ANTI-HUMAN PD-1 ANTIBODY CRYSTALS AND METHODS OF USE THEREOF
  申请人：Merck Sharp & Dohme Corp.

  公开号：EP3873941A1

  公开（公告）日：2021-09-08
• SYSTEM AND METHOD FOR AUTOMATIC DETECTION OF A PLURALITY OF SP02 TIME SERIES PATTERN TYPES
  申请人：Lynn Lawrence A.

  公开号：US20110208539A1

  公开（公告）日：2011-08-25

  The disclosed embodiments relate to a patient monitor for evaluating a patient. The patient monitor may comprise a sensor that is adapted to detect a sound associated with breathing of the patient and to produce a first output indicative of the sound, an oximeter that is adapted to receive an input from the patient and to produce a second output indicative of oxygen saturation of blood of the patient, and a processor adapted to receive at least the first output and the second output and to correlate the first output with the second output.