(E)-2-(2-hydroxystyryl)benzothiazole | 113191-92-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: (E)-2-(2-hydroxystyryl)benzothiazole
• 英文别名: 2-(trans-3-hydroxystyryl) benzothiazole；2-(trans-3-Hydroxystyryl)benzothiazole；3-[(E)-2-(1,3-benzothiazol-2-yl)ethenyl]phenol
• CAS: 113191-92-7
• 化学式: C₁₅H₁₁NOS
• 分子量: 253.324
• InChiKey: RINWWYQYFJLENS-CMDGGOBGSA-N

物化性质

• 沸点：
  480.1±48.0 °C(Predicted)
• 密度：
  1.348±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  61.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (E)-2-(2-hydroxystyryl)benzothiazole 在 palladium-carbon 氢气 作用下， 以 乙醇 为溶剂， 反应 3.0h， 以to obtain 5.5 g (yield 92%) of the title compound as pale gray crystals的产率得到2-[2-(3-Hydroxyphenyl)ethyl]benzothiazole
  参考文献：
  名称：

  Thiazole derivative and leukotriene antagonist containing the same as

  摘要：

  本发明涉及一种由以下式表示的噻唑衍生物、其药学上可接受的盐和含有其作为活性成分的白三烯拮抗剂：##STR1##其中R.sub.1和R.sub.2各自独立地表示氢原子、具有1至8个碳原子的烷基、较低的烷氧羰基基团或取代或未取代的苯基，或者共同表示对应于融合的环己烷环的四亚甲基基团或取代或未取代的含有卤素原子、较低的烷氧基、较低的烷氧羰基基团或具有1至3个碳原子的烷基的丁二烯基团；R.sub.3、R.sub.4、R.sub.5和R.sub.6各自独立地表示氢原子、羟基、较低的烷氧基、具有1至3个碳原子的烷基或卤素原子；A表示具有2至4个链成员的连接基团；B表示具有2至5个链成员的连接基团；Q表示羧基、较低的烷氧基、羟基、具有2至6个碳原子的烷氧羰基基团或5-四唑基基团。

  公开号：

  US04902700A1
• 作为产物：
  描述：

  间羟基苯甲醛 、 2-甲基苯并噻唑 、 乙酸酐 在 甲苯 、 甲醇 、 potassium carbonate 、 crude product 、 乙醚 作用下， 以 甲酸 为溶剂， 反应 26.0h， 以to obtain 20.6 g (yield 40%) of the title compound的产率得到(E)-2-(2-hydroxystyryl)benzothiazole
  参考文献：
  名称：

  Thiazole derivative and leukotriene antagonist containing the same as

  摘要：

  本发明涉及一种由以下式表示的噻唑衍生物、其药学上可接受的盐和含有其作为活性成分的白三烯拮抗剂：##STR1##其中R.sub.1和R.sub.2各自独立地表示氢原子、具有1至8个碳原子的烷基、较低的烷氧羰基基团或取代或未取代的苯基，或者共同表示对应于融合的环己烷环的四亚甲基基团或取代或未取代的含有卤素原子、较低的烷氧基、较低的烷氧羰基基团或具有1至3个碳原子的烷基的丁二烯基团；R.sub.3、R.sub.4、R.sub.5和R.sub.6各自独立地表示氢原子、羟基、较低的烷氧基、具有1至3个碳原子的烷基或卤素原子；A表示具有2至4个链成员的连接基团；B表示具有2至5个链成员的连接基团；Q表示羧基、较低的烷氧基、羟基、具有2至6个碳原子的烷氧羰基基团或5-四唑基基团。

  公开号：

  US04902700A1

文献信息

• Thiazole derivative and leukotriene antagonist containing the same as the effective ingredients
  申请人：MITSUBISHI KASEI CORPORATION

  公开号：EP0219436A2

  公开（公告）日：1987-04-22

  Disclosed are a thiazole derivative represented by the following formula, a pharmaceutically acceptable salt thereof and leukotriene antagonist containing the same as the active ingredients: wherein R, and Rz each independently represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, a lower alkoxycarbonyl group or a substituted or unsubstituted phenyl group or cooperatively represent a tetramethylene group corresponding to a fused cyclohexane ring or a butadienylene group which is unsubstituted or substituted with a halogen atom, a lower alkoxy group, a lower alkoxycarbonyl group or an alkyl group having 1 to 3 carbon atoms corresponding to a fused benzene ring; R3, R4, R5 and R6 each independently represent a hydrogen atom, a hydroxyl group, a lower alkoxy group, an alkyl group having 1 to 3 carbon atoms or a halogen atom; A represents a linking group having 2 to 4 chain members; B represents a linking group having 2 to 5 chain members; and Q represents a carboxyl group, a lower alkoxy group, a hydroxyl group, an alkoxycarbonyl group having 2 to 6 carbon atoms or a 5-tetrazolyl group.

  本发明公开了由下式代表的噻唑衍生物、其药学上可接受的盐和含有相同活性成分的白三烯拮抗剂： 其中 R 和 Rz 各自独立地代表氢原子、具有 1 至 8 个碳原子的烷基、低级烷氧基羰基或取代或未取代的苯基，或共同代表与融合环己烷环相对应的四亚甲基或未取代或被卤素原子取代的丁二烯基、低级烷氧基、低级烷氧基羰基或具有 1 至 3 个碳原子的与融合苯环相对应的烷基；R3、R4、R5 和 R6 各自独立地代表氢原子、羟基、低级烷氧基、具有 1 至 3 个碳原子的烷基或卤素原子；A 代表具有 2 至 4 个链成员的连接基团；B 代表具有 2 至 5 个链成员的连接基团；Q 代表羧基、低级烷氧基、羟基、具有 2 至 6 个碳原子的烷氧羰基或 5-四唑基。
• Cytotoxic anionic tribromo platinum(II) complexes containing benzothiazole and benzoxazole donors: synthesis, characterization, and structure-activity correlation
  作者：César M. Lozano、Osvaldo Cox、Mariel M. Muir、Johara D. Morales、Jorge L. Rodríguez-Cabán、Pablo E. Vivas-Mejía、Fernando A. Gonzalez

  DOI：10.1016/s0020-1693(97)05952-5

  日期：1998.4

  A series of platinum(II) complexes of the type [NEt4][PtLBr3] where L is a 2-styrylbenzothiazole or 2-styrylbenzoxazole was prepared. The complexes were characterized by their melting points, elemental analyses, W-Vis and far-infrared spectra, and H-1 and Pt-195 NMR spectroscopy. The NMR data are consistent with coordination of the benzoheterazole ligands to the Pt ion through the nitrogen atom. The ligands and the complexes were assayed for cytotoxicity against U937 human histiocytic lymphoma cells. It was observed that the ligands displayed very poor cytotoxicity, while the Pt(II) complexes demonstrated marked cytotoxicities and a structure-activity correlation was established. Pt(ll) complexes containing S as the heteroatom in the benzoheterazole ring were generally more active than their O-containing counterpart. The position and type of substituents in the styryl moiety were also important for biological activity. Our data indicate that adjacent methoxy functionalities were present in the most potent drugs tested. Further development of active Pt(II) complexes with improved solubilities is warranted. (C) 1998 Elsevier Science S.A.
• Dye-Sensitized Photoelectric Conversion Device
  申请人：Ikeda Masaaki

  公开号：US20110030801A1

  公开（公告）日：2011-02-10

  A photoelectric conversion device using a semiconductor fine material such as a semiconductor fine particle sensitized with a dye carried thereon, characterized in that the dye is a methine type dye having a specific partial structure, for example, a methine type dye having a specific carboxyl-substituted hetero ring on one side of a methine group and an aromatic residue substituted with a dialkylamino group or an organic metal complex residue on the other side of the methine group, or a methine type dye having a carboxyl-substituted aromatic ring on one side of a methine group and a heteroaromatic ring having a dialkylamino group or an organic metal complex residue on the otherside of the methine group; and a solar cell using the photoelectric conversion element. The photoelectric conversion element exhibits a conversion efficiency comparable or superior to that of a conventionally known photoelectric conversion element sensitized with a methine type dye.
• US4902700A
  申请人：——

  公开号：US4902700A

  公开（公告）日：1990-02-20
• US8338700B2
  申请人：——

  公开号：US8338700B2

  公开（公告）日：2012-12-25