The present invention relates to compounds of formula (I)
wherein R
1
and A are as defined in the specification as dual modulators of the serotonin 5-HT
2a
and dopamine D
3
receptors, their manufacture, pharmaceutical compositions containing them and their use as medicaments. Compounds of general formula (I) have high affinity for the dopamine D
3
and serotonin (5-Hydroxytryptamine; 5-HT) 5-HT
2A
receptors and are effective in the treatment of psychotic disorders, as well as other diseases such as depression and anxiety, drug dependence, dementias and memory impairment.
本发明涉及以下式(I)的化合物
其中R
1
和A如说明书中定义的作为
血清素5-HT
2a
和
多巴胺D
3
受体的双调节剂,它们的制备,含有它们的药物组合物以及它们作为药物的用途。一般式(I)的化合物对
多巴胺D
3
和
血清素(5-羟
色胺;5-HT)5-HT
2A
受体具有高亲和力,并且在治疗精神分裂症等疾病以及抑郁症、焦虑症、药物依赖、痴呆症和记忆障碍等其他疾病中具有有效性。