9-fluorenyl formate

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 9-fluorenyl formate
• 英文别名: 9H-fluoren-9-yl formate
• 化学式: C₁₄H₁₀O₂
• 分子量: 210.232
• InChiKey: IRPLHMWDUQMQBJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  9-羟基芴 、 三氯乙醛 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 31.0h， 以89%的产率得到9-fluorenyl formate
  参考文献：
  名称：

  在苯酚与氯醛存在下醇的选择性甲酰化

  摘要：

  在环境温度下，在无水K 2 CO 3上与丙酮中的乙二醛搅拌，在苯酚存在下，选择性地使伯醇和仲醇甲酰化，收率很高。

  DOI：

  10.1016/s0040-4020(02)00185-0

文献信息

• [EN] FUSED PYRAZOLE DERIVATIVES AS JAK INHIBITORS<br/>[FR] DÉRIVÉS DE PYRAZOLE CONDENSÉS UTILISÉS EN TANT QU'INHIBITEURS DE JAK
  申请人：ALMIRALL SA

  公开号：WO2017220431A1

  公开（公告）日：2017-12-28

  Novel fused pyrazole derivatives of Formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).

  公开了式（I）的新型融合吡唑衍生物；以及它们的制备方法，包含它们的药物组合物以及它们作为Janus激酶（JAK）抑制剂在治疗中的用途。
• Pyrroles substituted by oligonucleotides
  申请人：Mandrand Bernard

  公开号：US20060189555A1

  公开（公告）日：2006-08-24

  The invention relates to novel pyrrole derivatives of the formula (I) which make it possible to immobilize and address oligonucleotides by electropolymerization. Said invention also relates to thus produced electroactive polymers and to methods for using them for detecting, identifying and dosing analytes in a sampe. (I) wherein R 1 is one type of oligonucleotide, Y is S or O, X is a spacer arm selected from —(CH 2 )—O—, —(CH 2 )PO—[(CH 2 ) 2 —O] q —, —(CH2 )r ; —CO—NR—(CH 2)r -0-, —CH 2r —NCH 3 —(CH 2 ) r —O—, —CH 2 ) r CO—NR′—[CH 2 ) 2 —O] s —, —(CH 2 ) r NCH 3 [(CH 2 ) 2 —O]S—, R′ is H or CH 3 , n is an integer number ranging from 1 to 5, p is an integer number ranging from 1 to 2, q is an integer number ranging from 1 to 4, r is an integer number ranging from 1 to 3, r′ is an integer number ranging from 1 to 3, s is an integer number ranging from 1 to 3, n, p, q, r, r′ and s are identical or different, a pyrrole cycle is substituted in a position 2, 3, 4 or 5.

  该发明涉及公式（I）的新型吡咯衍生物，可以通过电聚合固定和寻址寡核苷酸。该发明还涉及因此产生的电活性聚合物，以及使用它们用于检测、鉴定和定量样品中的分析物的方法。在公式（I）中，R1是一种类型的寡核苷酸，Y是S或O，X是从—（CH2）—O—、—（CH2）PO—（（CH2）2—O）q—、—（CH2）r；—CO—NR—（CH2r）-O-、—CH2r—NCH3—（CH2）r—O—、—CH2rCO—NR′—（CH2）2—O）s—、—（CH2）rNCH3（（CH2）2—O）S—中选择的间隔臂，R′是H或CH3，n是从1到5的整数，p是从1到2的整数，q是从1到4的整数，r是从1到3的整数，r′是从1到3的整数，s是从1到3的整数，n、p、q、r、r′和s是相同或不同的，吡咯环在位置2、3、4或5上被取代。
• METHOD FOR MANUFACTURING NOVEL NITROGEN-CONTAINING COMPOUND OR SALT THEREOF AND MANUFACTURING INTERMEDIATE OF NOVEL NITROGEN-CONTAINING COMPOUND OR SALT THEREOF
  申请人：FUJIFILM Corporation

  公开号：US20180008583A1

  公开（公告）日：2018-01-11

  Provided are a method for efficiently manufacturing a nitrogen-containing compound, which is used for manufacturing a treatment agent for integrin-related diseases, or a salt thereof and a manufacturing intermediate of the compound or a salt thereof. A method for manufacturing a novel nitrogen-containing compound or a salt thereof includes (1) a step of obtaining a compound represented by Formula [10] or a salt thereof through an amidation reaction; and (2) a step of deprotecting the compound represented by Formula [10] or a salt thereof.

  提供了一种用于高效制造含氮化合物的方法，该方法用于制造治疗整合素相关疾病的治疗剂或其盐，以及该化合物或其盐的制造中间体。 制造一种新型含氮化合物或其盐的方法包括（1）通过酰胺化反应获得由式[10]表示的化合物或其盐的步骤；以及（2）去保护由式[10]表示的化合物或其盐的步骤。
• [EN] SULFONIUM SULFATES, THEIR PREPARATION AND USE<br/>[FR] SULFATES DE SULFONIUM, LEUR PRÉPARATION ET UTILISATION
  申请人：BASF SE

  公开号：WO2012113829A1

  公开（公告）日：2012-08-30

  The present invention relates to a heat-curable composition comprising (a) at least one compound which is capable of undergoing cationic polymerization; and (b) at least one sulfonium sulfate selected from compounds of the formulae Ia and Ib where Yn- is a monovalent or divalent anion selected from (1) where n, M, R1 to R10 are as defined in claim 1 and in the description. The present invention also relates to novel sulfonium sulfates of the formulae Ia and Ib, to a process for curing cationically polymerizable material and to the cured material obtained by said process.

  本发明涉及一种热固化组合物，包括（a）至少一种能够进行阳离子聚合的化合物；和（b）选择自式Ia和Ib的至少一种砜酸盐，其中Yn-是从（1）中选择的一价或二价阴离子，其中n、M、R1至R10如权利要求1和描述中所定义。本发明还涉及式Ia和Ib的新型砜酸盐，以及用于固化阳离子聚合材料的工艺和通过该工艺获得的固化材料。
• [EN] MACROCYCLIC PEPTIDES USEFUL AS IMMUNOMODULATORS<br/>[FR] PEPTIDES MACROCYCLIQUES UTILES COMME IMMUNOMOLDULATEURS
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2016077518A1

  公开（公告）日：2016-05-19

  The present disclosure provides compounds which are immunomodulators and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.

  本公开提供了一些免疫调节剂化合物，因此对于改善各种疾病，包括癌症和传染病，具有用处。