N1-[2-(1-氮丙啶基)乙基]-1,2-乙二胺 | 23435-23-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: N1-[2-(1-氮丙啶基)乙基]-1,2-乙二胺
• 英文名称: NSC-174041
• 英文别名: 1-<2-<(2-aminoethyl)amino>ethyl>aziridine；1-aziridine；N-(2-aziridin-1-yl-ethyl)-ethylenediamine；N-(2-Aziridin-1-yl-aethyl)-aethylendiamin；N-(2-Aminoethyl)-1-aziridineethanamine；N'-[2-(aziridin-1-yl)ethyl]ethane-1,2-diamine
• CAS: 23435-23-6
• 化学式: C₆H₁₅N₃
• 分子量: 129.205
• InChiKey: XJNAQZHMIAKQOK-UHFFFAOYSA-N

物化性质

• 沸点：
  96 °C(Press: 10 Torr)
• 密度：
  0.943 g/cm3(Temp: 23 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  N1-[2-(1-氮丙啶基)乙基]-1,2-乙二胺 在 氨 、 氢气 作用下， 以 水 为溶剂， 生成 三乙烯四胺
  参考文献：
  名称：

  Bobylev, V. A.; Dalin, A. R.; Borisenko, I. V., Journal of general chemistry of the USSR, 1989, vol. 59, # 5.2, p. 1003 - 1007

  摘要：

  DOI：
• 作为产物：
  描述：

  N'-[2-(2-chloroethylamino)ethyl]ethane-1,2-diamine 在 sodium hydroxide 作用下， 生成 N1-[2-(1-氮丙啶基)乙基]-1,2-乙二胺
  参考文献：
  名称：

  Chechik, V. O.; Bobylev, V. A.; Selivanov, S. I., Journal of general chemistry of the USSR, 1991, vol. 61, # 7.2, p. 1541 - 1544

  摘要：

  DOI：

文献信息

• AMINOALCOHOL LIPIDOIDS AND USES THEREOF
  申请人：Mahon Kerry Peter

  公开号：US20110293703A1

  公开（公告）日：2011-12-01

  Aminoalcohol lipidoids are prepared by reacting an amine with an epoxide-terminated compound are described. Methods of preparing aminoalcohol lipidoids from commercially available starting materials are also provided. Aminoalcohol lipidoids may be prepared from racemic or stereochemically pure epoxides. Aminoalcohol lipidoids or salts forms thereof are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these aminoalcohol lipidoid compounds, they are particularly suited for the delivery of polynucleotides. Complexes, micelles, liposomes or particles containing the inventive lipidoids and polynucleotide have been prepared. The inventive lipidoids may also be used in preparing microparticles for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.

  本文描述了通过将胺与环氧末端化合物反应制备氨基醇脂质体的方法。还提供了从商业起始材料制备氨基醇脂质体的方法。氨基醇脂质体可以从外消旋或立体化学纯的环氧化合物制备。氨基醇脂质体或其盐形式最好是可生物降解和生物相容的，并可用于各种药物输送系统。鉴于这些氨基醇脂质体化合物的氨基基团，它们特别适用于多核苷酸的输送。已经制备了包含创新脂质体和多核苷酸的复合物、胶束、脂质体或粒子。创新脂质体也可以用于制备药物输送的微粒。鉴于它们能够缓冲其周围环境的pH值，它们在输送不稳定剂方面特别有用。
• Composition containing aziridino groups and use thereof
  申请人：3M Innovative Properties Company

  公开号：EP1820815A1

  公开（公告）日：2007-08-22

  The invention relates to a composition comprising a prepolymer as component (A), wherein the prepolymer comprises aziridino groups and is characterized by an equivalent weight EW1, a crosslinker as component (B), wherein the crosslinker has a structure being different from the structure of the prepolymer and comprises aziridino groups and is characterized by an equivalent weight EW2, an initiator as component (C) being able to start curing of the composition, optionally filler(s) as component (D) and optionally additive(s) as component (E), wherein equivalent weight is defined as (molecular mass of the molecule) / (number of aziridino groups present in the molecule) and wherein EW1 > EW2. The invention also relates to the use of the composition for coating, sealing, moulding, adhering, making impressions, producing a dental material.

  本发明涉及一种组合物，该组合物包括作为组分（A）的预聚物，其中预聚物包含氮丙啶基团，其特征在于等效重量 EW1；作为组分（B）的交联剂，其中交联剂的结构与预聚物的结构不同，包含氮丙啶基团，其特征在于等效重量 EW2、作为成分（C）的引发剂能够启动组合物的固化，作为成分（D）的可选填料和作为成分（E）的可选添加剂，其中等效重量定义为（分子的分子质量）/（分子中存在的氮丙啶基数），其中 EW1 > EW2。 本发明还涉及将该组合物用于涂层、密封、成型、粘合、制模、生产牙科材料。
• Aminoalcohol lipidoids and uses thereof
  申请人：Massachusetts Institute of Technology

  公开号：US10189802B2

  公开（公告）日：2019-01-29

  Aminoalcohol lipidoids are prepared by reacting an amine with an epoxide-terminated compound are described. Methods of preparing aminoalcohol lipidoids from commercially available starting materials are also provided. Aminoalcohol lipidoids may be prepared from racemic or stereochemically pure epoxides. Aminoalcohol lipidoids or salts forms thereof are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these aminoalcohol lipidoid compounds, they are particularly suited for the delivery of polynucleotides. Complexes, micelles, liposomes or particles containing the inventive lipidoids and polynucleotide have been prepared. The inventive lipidoids may also be used in preparing microparticles for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.

  本文介绍了通过胺与环氧化物封端化合物反应制备氨基醇脂质的方法。还提供了从市售起始原料制备氨基醇类脂质的方法。氨基醇脂质可由外消旋或立体化学纯环氧化物制备。氨基醇类脂质或其盐类最好具有生物降解性和生物相容性，可用于各种给药系统。考虑到这些氨基醇类脂化合物的氨基，它们特别适合用于多核苷酸的给药。现已制备出含有本发明类脂化合物和多核苷酸的复合物、胶束、脂质体或颗粒。本发明的类脂质还可用于制备给药微粒。由于本发明脂质具有缓冲周围环境 pH 值的能力，因此在递送易变药剂方面特别有用。
• Method for making water-soluble polymers of lower alkylene imines
  申请人：UNION CARBIDE & CARBON CORP

  公开号：US02553696A1

  公开（公告）日：1951-05-22
• Oligomers of aziridines and N-?-aziridinoethylamides
  作者：R. G. Kostyanovskii、V. P. Leshchinskaya、R. K. Alekperov、G. K. Kadorkina、L. L. Shustova、Yu. I. �l'natanov、G. L. Gromova、A. �. Aliev、I. I. Chervin

  DOI：10.1007/bf00959886

  日期：1988.11