N-[2-[(2-氨乙基)氨基]乙基]-1,4-二乙胺哌嗪 | 31329-52-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 中文名称: N-[2-[(2-氨乙基)氨基]乙基]-1,4-二乙胺哌嗪
• 英文名称: N-[2-[(2-Aminoethyl)amino]ethyl]-1,4-piperazine diethanamine
• 英文别名: N'-[2-[2-[4-(2-aminoethyl)piperazin-1-yl]ethylamino]ethyl]ethane-1,2-diamine
• CAS: 31329-52-9
• 化学式: C₁₂H₃₀N₆
• 分子量: 258.41
• InChiKey: KFCNQQJCRIQVPJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.7
• 重原子数：
  18
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  82.6
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  N1-[2-(1-氮丙啶基)乙基]-1,2-乙二胺 、 N-氨乙基哌嗪 在 氢气 作用下， 以 水 为溶剂， 生成 N-[2-[(2-氨乙基)氨基]乙基]-1,4-二乙胺哌嗪
  参考文献：
  名称：

  Bobylev, V. A.; Dalin, A. R.; Borisenko, I. V., Journal of general chemistry of the USSR, 1989, vol. 59, # 5.2, p. 1003 - 1007

  摘要：

  DOI：

文献信息

• Multi-step process for converting cyclic alkyleneureas into their corresponding alkyleneamines
  申请人：NOURYON CHEMICALS INTERNATIONAL B.V.

  公开号：US11236039B2

  公开（公告）日：2022-02-01

  The invention pertains to a process for converting a feedstock comprising cyclic alkyleneureas into their corresponding alkyleneamines, comprising —a CO2 removal step in which cyclic alkyleneureas are converted into their corresponding alkyleneamines by reacting cyclic alkyleneureas in the liquid phase with water with removal of CO2, —an amine removal step wherein cyclic alkyleneureas are converted in a reactive separation process into their corresponding alkyleneamines by reaction with an amine compound selected from the group of primary amines or secondary amines which have a higher boiling point than the alkyleneamines formed during the process. It has been found that the combination of a CO2 removal step and an amine removal step makes it possible to convert alkyleneureas into the corresponding amines in an efficient manner in a high reaction rate.

  本发明涉及一种将由环亚烷基脲组成的原料转化为相应的亚烷基胺的工艺，该工艺包括 -二氧化碳脱除步骤，在该步骤中，环亚烷基脲在液相中与水反应，脱除二氧化碳，从而将环亚烷基脲转化为相应的亚烷基胺、-胺脱除步骤，其中环亚烷基脲在反应分离过程中与选自伯胺或仲胺组的胺化合物反应，将环亚烷基脲转化为相应的亚烷基胺，伯胺或仲胺的沸点高于该过程中形成的亚烷基胺。研究发现，将二氧化碳脱除步骤和胺脱除步骤结合起来，可以高效率地将亚烷基脲转化为相应的胺。
• Reactive separation process to convert cyclic alkylene ureas into their corresponding alkylene amines
  申请人：NOURYON CHEMICALS INTERNATIONAL B.V.

  公开号：US11339116B2

  公开（公告）日：2022-05-24

  A process to convert cyclic alkylene ureas into their corresponding alkylene amines is provided. An exemplary process includes reacting the cyclic alkylene ureas with an amine compound chosen from the group of primary amines or secondary amines that have a higher boiling point than the alkylene amines formed during the process, wherein the process is a reactive separation process and the reaction mixture contains less than about 10 wt % of water on the basis of total weight of the reaction mixture.

  本发明提供了一种将环亚烷基脲转化为相应的亚烷基胺的工艺。一种示例性工艺包括将环亚烷基脲与选自伯胺或仲胺组的胺化合物反应，伯胺或仲胺的沸点高于在该工艺中形成的亚烷基胺，其中该工艺为反应分离工艺，且以反应混合物的总重量为基准，反应混合物中水的含量小于约 10 wt %。
• REACTIVE SEPARATION PROCESS TO CONVERT CYCLIC ALKYLENE UREAS INTO THEIR CORRESPONDING ALKYLENE AMINES
  申请人：Nouryon Chemicals International B.V.

  公开号：EP3665154B1

  公开（公告）日：2021-05-12
• MULTI-STEP PROCESS FOR CONVERTING CYCLIC ALKYLENEUREAS INTO THEIR CORRESPONDING ALKYLENEAMINES
  申请人：NOURYON CHEMICALS INTERNATIONAL B.V.

  公开号：US20200165187A1

  公开（公告）日：2020-05-28

  A process for converting a feedstock comprising cyclic alkyleneureas into their corresponding alkyleneamines is provided. The process includes a CO 2 removal step in which cyclic alkyleneureas are converted into their corresponding alkyleneamines by reacting cyclic alkyleneureas in the liquid phase with water with removal of CO 2 . The exemplary process further includes an amine removal step wherein cyclic alkyleneureas are converted in a reactive separation process into their corresponding alkyleneamines by reaction with an amine compound selected from the group of primary amines or secondary amines which have a higher boiling point than the alkyleneamines formed during the process.