毒理性
氨曲南具有与其他β-内酰胺类抗生素相似的全身毒性，但目前尚不清楚它是否会引起类似青霉素或头孢菌素类抗生素引起的肝损伤。在高剂量静脉注射氨曲南治疗期间（10%至38%），无症状血清转氨酶升高很常见。这些酶异常通常是轻至中度的、无症状的、自限性的，并且不需要停药。与其它比较的抗生素相比，氨曲南治疗期间酶升高的发生略为常见。归因于氨曲南的明显肝损伤和黄疸的病例极为罕见，因为尚未有单个病例报告。因此，关于损伤的潜伏期或模式的资料。有报告称，在开始使用氨曲南后3至5天内出现明显的转氨酶升高的情况，但这些病例没有黄疸，且在停药后迅速解决。
Aztreonam has systemic toxicities that are similar to those of other beta lactam antibiotics, but it is unclear whether it can cause hepatic injury similar to that of the penicillins or cephalosporins. Asymptomatic serum aminotransferase elevations are common during high dose, intravenous aztreonam therapy (10% to 38%). The enzyme abnormalities are usually mild-to-moderate, asymptomatic, self-limited and not requiring drug discontinuation. Enzyme elevations occur slightly more commonly during aztreonam therapy than with other comparative antibiotics. Cases of frank liver injury and jaundice attributable to aztreonam must be extremely rare as no individual cases have been reported. For this reason, there is no data regarding the latency or pattern of the injury. Instances of marked aminotransferase elevations within 3 to 5 days of starting aztreonam have been reported, but these cases were without jaundice and resolved rapidly once the drug was stopped.
来源:LiverTox
