5-甲基-1-苯基-2(1H)-吡啶硫酮 | 914918-76-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 5-甲基-1-苯基-2(1H)-吡啶硫酮
• 英文名称: 2(1H)-Pyridinethione, 5-methyl-1-phenyl-
• 英文别名: 5-methyl-1-phenylpyridine-2-thione
• CAS: 914918-76-6
• 化学式: C₁₂H₁₁NS
• 分子量: 201.292
• InChiKey: LLTUKCIPMRSWGS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  35.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  哌非尼酮 在 劳森试剂 作用下， 以 甲苯 为溶剂， 生成 5-甲基-1-苯基-2(1H)-吡啶硫酮
  参考文献：
  名称：

  WO2006/122154

  摘要：

  公开号：

文献信息

• Method of modulating stress-activated protein kinase system
  申请人：Blatt M. Lawrence

  公开号：US20060270612A1

  公开（公告）日：2006-11-30

  Disclosed are methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of at least one p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the at least one p38 MAPK by the compound. Also disclosed are derivatives of pirfenidone. These derivatives can modulate a stress activated protein kinase (SAPK) system.

  本发明涉及使用活性化合物调节应激激活蛋白激酶（SAPK）系统的方法，该活性化合物对至少一种p38 MAPK的抑制作用具有低效性；并且所述接触是在低百分比抑制浓度下进行的SAPK调节浓度，以抑制化合物对至少一种p38 MAPK的作用。此外，本发明还涉及吡非酮的衍生物，这些衍生物可以调节SAPK系统。
• Methods of Treating Atrial Fibrillation with P38 Inhibitor Compounds
  申请人：Olgin Jeff

  公开号：US20100029578A1

  公开（公告）日：2010-02-04

  The invention disclosed herein relates generally to compounds and methods useful in treating or preventing atrial fibrillation (AF).

  本发明涉及通常用于治疗或预防房颤(AF)的化合物和方法。
• METHODS OF TREATING ATRIAL FIBRILLATION WITH P38 INHIBITOR COMPOUNDS
  申请人：Olgin Jeff

  公开号：US20120046321A1

  公开（公告）日：2012-02-23

  The invention disclosed herein relates generally to compounds and methods useful in treating or preventing atrial fibrillation (AF).

  本发明涉及一般与化合物和方法有关，用于治疗或预防心房颤动（AF）。
• METHOD OF MODULATING STRESS-ACTIVATED PROTEIN KINASE SYSTEM
  申请人：Blatt Lawrence M.

  公开号：US20120258924A1

  公开（公告）日：2012-10-11

  Disclosed are methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of at least one p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the at least one p38 MAPK by the compound. Also disclosed are derivatives of pirfenidone. These derivatives can modulate a stress activated protein kinase (SAPK) system.

  本发明涉及使用活性化合物调节应激激活蛋白激酶（SAPK）系统的方法，其中该活性化合物对至少一种p38 MAPK抑制的效力较低；并且该接触是在该化合物对至少一种p38 MAPK的抑制浓度低百分比的SAPK调节浓度下进行的。本发明还涉及吡非尼酮的衍生物，这些衍生物可以调节应激激活蛋白激酶（SAPK）系统。
• Pyridine-2-one-derivatives as modulators of stress-activated protein kinase system
  申请人：Intermune, Inc.

  公开号：EP2591784A1

  公开（公告）日：2013-05-15

  Disclosed are methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of at least one p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the at least one p38 MAPK by the compound. Also disclosed are derivatives of pirfenidone. These derivatives can modulate a stress activated protein kinase (SAPK) system.

  公开了用活性化合物调节应激活化蛋白激酶（SAPK）系统的方法，其中活性化合物对抑制至少一种p38 MAPK表现出较低的效力；并且接触是在SAPK调节浓度下进行的，该浓度是化合物抑制至少一种p38 MAPK的低百分比抑制浓度。还公开了吡非尼酮的衍生物。这些衍生物可以调节应激活化蛋白激酶（SAPK）系统。