3-氨基酪氨酰胺 | 81666-88-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3-氨基酪氨酰胺
• 中文别名: 2-氨基-4-(2-氨基乙基)苯酚
• 英文名称: 3-amino-4-hydroxyphenylethylamine
• 英文别名: 2-amino-4-(2-amino-ethyl)-phenol；3.1²-Diamino-4-oxy-1-aethyl-benzol；3-Amino-4-oxy-β-phenaethylamin；2-Amino-4-(2-amino-aethyl)-phenol；3-Amino-tyramin；3-Aminotyramine；2-amino-4-(2-aminoethyl)phenol
• CAS: 81666-88-8
• 化学式: C₈H₁₂N₂O
• 分子量: 152.196
• InChiKey: TXORYVHZKLWJBK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  72.3
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-氨基酪氨酰胺 在 盐酸 、 sodium nitrite 、 sodium azide 作用下， 以 水 为溶剂， 反应 1.0h， 生成 4-(2-amino-ethyl)-2-azido-phenol
  参考文献：
  名称：

  OPHTHALMIC LENS MATERIALS CONTAINING CHROMOPHORES THAT ABSORB BOTH UV AND SHORT WAVELENGTH VISIBLE LIGHT

  摘要：

  吸收紫外线和短波长可见光的色素团被披露。这些色素团特别适用于人工晶状体材料。

  公开号：

  US20090043007A1
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 生成 3-氨基酪氨酰胺
  参考文献：
  名称：

  Waser; Sommer, Helvetica Chimica Acta, 1923, vol. 6, p. 60

  摘要：

  DOI：

文献信息

• Reduction of the Nitro Group to Amine by Hydroiodic Acid to Synthesize o-Aminophenol Derivatives as Putative Degradative Markers of Neuromelanin
  作者：Kazumasa Wakamatsu、Hitomi Tanaka、Keisuke Tabuchi、Makoto Ojika、Fabio Zucca、Luigi Zecca、Shosuke Ito

  DOI：10.3390/molecules19068039

  日期：——

  acid (DOPAC) or 3,4-dihydroxyphenylmandelic acid (DOMA) and 3,4-dihydroxyphenylethanol (DOPE) or 3,4-dihydroxyphenylethyleneglycol (DOPEG), respectively. These o-aminophenol compounds were synthesized by the nitration of phenol derivatives followed by reduction with hydroiodic acid (HI), and they could be identified by HPLC in HI hydrolysates of SN-NM and LC-NM. This degradative approach by HI hydrolysis

  神经黑色素 (NM) 在黑质 (SN) 的多巴胺能神经元和蓝斑 (LC) 的去甲肾上腺素能神经元中产生。这些神经元中 NM 的合成是大脑衰老的一个组成部分，有证据表明，这种色素可能参与神经退行性疾病（如帕金森病）的发病机制。NM 被认为源自多巴胺 (DA) 或去甲肾上腺素 (NE) 在半胱氨酸、多萜醇和蛋白质的参与下的氧化聚合。然而，来自SN（SN-NM）和LC（LC-NM）的NM的化学结构仍然存在未知方面。在这项研究中，我们设计了一种新方法来合成邻氨基苯酚化合物，作为儿茶酚胺及其代谢物的推定降解产物，可将其纳入 NM。这些化合物是氨基羟基苯乙胺 (AHPEA) 异构体、氨基羟基苯乙酸 (AHPAA) 异构体和氨基羟基乙基苯 (AHEB) 异构体，预计它们来自 DA 或 NE、3,4-二羟基苯乙酸 (DOPAC) 或 3,4-二羟基苯扁桃酸 (DOMA) ) 和 3,4-二羟基苯基乙醇 (DOPE)
• Ophthalmic lens materials containing chromophores that absorb both UV and short wavelength visible light
  申请人：Alcon, Inc.

  公开号：US07728051B2

  公开（公告）日：2010-06-01

  Chromophores that absorb both UV and short wavelength visible light are disclosed. The chromophores are particularly suitable for use in intraocular lens materials.

  本发明揭示了一种吸收紫外线和短波长可见光的色团。该色团特别适用于人工晶体透镜材料。
• Bis(benzylpyrrolidine)Derivatives as dopamine agonists
  申请人：SYNTEX (U.S.A.) INC.

  公开号：EP0404115A1

  公开（公告）日：1990-12-27

  Dopamine agonist compounds useful in the treatment of hypertension and congestive heart failure in mammals are disclosed. The dopamine agonist compounds include racemic and non-racemic mixtures of chiral compounds as well as optically pure R,R; R,S and S,S stereoisomers which are all intended to be schematically described by the following general formula (I) wherein: R₁ is independently hydrogen, lower alkyl, -C(O)R₃, or -C(O)NR₃R₄, wherein R₃ and R₄ are independently lower alkyl, optionally substituted phenyl or phenyl lower alkyl; R₂ is hydrogen or lower alkyl-, X is -(CH₂)m- or -(CH₂)nY(CH₂)n-, where m is an integer from 1 to 10, n is an integer of 1 to 3, and Y is oxygen or sulfur; All of R₁, and R₂ are most preferably hydrogen, X is most preferably -(CH₂)m- and the preferred optically pure R stereoisomer (most preferably R,R stereoisomer) of the dopamine agonist is preferably in the form of a pharmaceutically acceptable salt, preferably included in a dosage form with a suitable carrier.

  本发明公开了可用于治疗哺乳动物高血压和充血性心力衰竭的多巴胺激动剂化合物。多巴胺激动剂化合物包括手性化合物的外消旋和非外消旋混合物，以及光学纯的 R,R；R,S 和 S,S 立体异构体，它们均按下式（I）示意描述 其中 R₁ 独立地为氢、低级烷基、-C(O)R₃ 或 -C(O)NR₃R₄ ，其中 R₃ 和 R₄ 独立地是低级烷基、任选取代的苯基或苯基低级烷基； R₂ 是氢或低级烷基、 X 是-(CH₂)m- 或-(CH₂)nY(CH₂)n-，其中 m 是 1 至 10 的整数，n 是 1 至 3 的整数，Y 是氧或硫； 所有 R₁和 R₂ 最优选为氢，X 最优选为-(CH₂)m-，多巴胺激动剂的优选光学纯 R 立体异构体（最优选 R，R 立体异构体）优选为药学上可接受的盐的形式，最好与合适的载体一起包含在剂型中。
• Apparatus for continuously monitoring a plurality of chemical analytes through a single optical fiber and method of making
  申请人：ABBOTT LABORATORIES

  公开号：EP0477501A2

  公开（公告）日：1992-04-01

  A CO₂/O₂ or pH/O₂ gas sensor (10) comprising a single optical fiber (11) and a method for making the same. The optical fiber carries light signals at different wavelengths for monitoring either CO₂ concentration or pH level, in combination with O₂ concentration. Attached to the distal end (23) of the fiber-optic probe is a cylindrical pellet (17) that has one surface (25) covered by a light reflective material (gold foil (15)) and the other surface attached adjacent to the distal end of the optical fiber. Depending on whether the sensor is to monitor either CO₂ or pH, the pellet comprises either a CO₂ analyte indicator molecule or a pH analyte indicator molecule covalently bonded to a polymer matrix material. Also adjacent to the distal end of the optical fiber is disposed a second polymer matrix material which is codissolved with an O₂ analyte reactive indicator molecule (19). The second polymer matrix material is either interposed between the cylindrical pellet and the distal end of the optical fiber or surrounds the cylindrical pellet. If pH is being measured, the distal end of the optical fiber is coated with a hydrophilic material that is permeable to water. Conversely, if CO₂ is being monitored, the distal end is coated with a hydrophobic material.

  一种由单根光纤 (11) 组成的 CO₂/O₂ 或 pH/O₂ 气体传感器 (10) 及其制造方法。光纤携带不同波长的光信号，用于监测 CO₂ 浓度或 pH 值，以及 O₂ 浓度。光纤探头的远端 (23) 连接着一个圆柱形颗粒 (17)，该颗粒的一个表面 (25) 被光反射材料（金箔 (15)）覆盖，另一个表面则与光纤远端相邻。根据传感器是监测 CO₂ 还是 pH 值，颗粒由共价键合到聚合物基质材料上的 CO₂ 分析指示剂分子或 pH 分析指示剂分子组成。在光纤远端附近还放置有第二种聚合物基质材料，该材料与 O₂ 分析活性指示剂分子共溶 (19)。第二种聚合物基质材料或者位于圆柱形颗粒和光纤远端之间，或者环绕在圆柱形颗粒周围。如果要测量 pH 值，则光纤远端涂有亲水性材料，可渗透水。相反，如果要监测 CO₂，则远端涂有疏水材料。
• Improved configuration fiber-optic blood gas sensor bundle and method of making
  申请人：ABBOTT LABORATORIES

  公开号：EP0457292A2

  公开（公告）日：1991-11-21

  A bundle of fiber-optic sensors that resist breakage, for use in measuring pH, CO₂, and O₂ concentration, and a method of making the same. Three optical fibers (15,17,19) are enclosed in a common polyimide sheath (13) and extend parallel to one another toward a distal end of the sensor, where they are bonded together in a mutually supportive array. At the distal end of one of these optical fibers is disposed a pellet (21) comprising a CO₂ analyte indicator molecule codissolved within a polymer matrix (22). A thin reflective surface of gold foil (20) is provided on the pellet such that incident light transmitted through the optical fiber and polymer matrix is reflected back into the optical fiber. The CO₂ polymer matrix absorbs light of a given wavelength to an extent dependent upon the level of CO₂ present. Similarly, on the distal end of a second optical fiber is disposed a pH pellet (25) comprising a pH analyte indicator matrix with a thin reflective gold foil (24) attached for reflecting light that has passed through the pH analyte indicator matrix back into the optical fiber. The pH analyte indicator matrix absorbs light of a given wavelength to an extent dependent upon the hydrogen ion concentration (pH level) of a surrounding fluid. The third optical fiber is used for measuring oxygen concentration. An O₂ indicator matrix (27) covers the distal ends of at least two of the three optical fibers; however, at least a portion of the pH optical fiber and the pH pellet are free of the O₂ indicator matrix, which is hydrophobic. The oxygen indicator matrix phosphoresces for an interval of time that decreases in proportion to the surrounding oxygen gas concentration. The phosphorescent and reflected light signals are transmitted to light detectors through the optical fibers for comparison to reference signals, so that the analyte concentrations can be determined.

  一种用于测量 pH 值、CO₂ 和 O₂ 浓度的抗断裂光纤传感器束及其制造方法。三根光纤（15、17、19）被包裹在一个共同的聚酰亚胺护套（13）中，并相互平行地向传感器的远端延伸，在那里它们被粘合在一起，形成一个相互支撑的阵列。在其中一根光纤的远端放置了一个颗粒 (21)，该颗粒包括一个溶解在聚合物基质 (22) 中的 CO₂ 分析指示剂分子。小球上有一个薄薄的金箔反射面（20），这样，通过光纤和聚合物基质的入射光就会反射回光纤。CO₂ 聚合物基质对特定波长光线的吸收程度取决于 CO₂ 的含量。同样，在第二根光纤的远端放置了一个 pH 颗粒（25），该颗粒由 pH 分析物指示剂基质组成，基质上附有薄的反射金箔（24），用于将穿过 pH 分析物指示剂基质的光反射回光纤。pH 分析物指示基质吸收特定波长的光的程度取决于周围流体的氢离子浓度（pH 值）。第三根光纤用于测量氧气浓度。O₂ 指示基质 (27) 覆盖了三根光纤中至少两根光纤的远端；但是，pH 光纤和 pH 颗粒的至少一部分没有 O₂ 指示基质，因为 O₂ 指示基质是疏水性的。氧指示基质会在一定的时间间隔内发出磷光，磷光的衰减与周围氧气浓度成正比。磷光信号和反射光信号通过光纤传输到光检测器，与参考信号进行比较，从而确定分析物浓度。