4-acetamido-N-phenethylbenzamide | 349394-87-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-acetamido-N-phenethylbenzamide
• 英文别名: 4-Acetamido-N-(2-phenylethyl)benzamide
• CAS: 349394-87-2
• 化学式: C₁₇H₁₈N₂O₂
• mdl: MFCD00578788
• 分子量: 282.342
• InChiKey: MNPSTSJIPGRCAX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  对乙酰氨基苯甲醛 、 2-苯乙胺 在 叔丁基过氧化氢 、 zinc dibromide 作用下， 以 水 为溶剂， 反应 16.0h， 以90%的产率得到4-acetamido-N-phenethylbenzamide
  参考文献：
  名称：

  Zinc(II)-catalyzed oxidative amidation of arylaldehydes with alkylamines under solvent-free conditions

  摘要：

  The first zinc-catalyzed oxidative amidation of arylaldehydes has been developed. Various amides were prepared in good yields under solvent-free and mild reaction conditions. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.12.010

文献信息

• p-Acylaminobenzamides
  申请人：ELI LILLY AND COMPANY

  公开号：EP0213924A2

  公开（公告）日：1987-03-11

  This invention provides certain 4-acylamino benzamide derivatives, their pharmaceutical formulations, and their use as anticonvulsant agents.

  本发明提供了某些 4-酰氨基苯甲酰胺衍生物、其药物制剂及其作为抗惊厥剂的用途。
• BIR DOMAIN BINDING COMPOUNDS
  申请人：Jarvis Scott

  公开号：US20100292269A1

  公开（公告）日：2010-11-18

  The present invention is directed towards an isomer, an enantiomer, a diastereoisomer, or a tautomer of a pyrrolidine compound represented by Formula I: in which the substituents R 1 , R 1a , R 2 , R 2a , R 3 , A and Q are defined herein; or a prodrug, or a salt thereof, and which bind to IAP BIR domains. In particular, the compounds are useful in treating proliferative disorders such as cancer
• US4642379A
  申请人：——

  公开号：US4642379A

  公开（公告）日：1987-02-10
• Zinc(II)-catalyzed oxidative amidation of arylaldehydes with alkylamines under solvent-free conditions
  作者：Min Zhang、Xiao-Feng Wu

  DOI：10.1016/j.tetlet.2012.12.010

  日期：2013.2

  The first zinc-catalyzed oxidative amidation of arylaldehydes has been developed. Various amides were prepared in good yields under solvent-free and mild reaction conditions. (C) 2012 Elsevier Ltd. All rights reserved.