2-[2-[2-(二氨基亚甲基氨基)乙基二硫基]乙基]胍二氢溴酸盐 | 1072-13-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 2-[2-[2-(二氨基亚甲基氨基)乙基二硫基]乙基]胍二氢溴酸盐
• 中文别名: 1,1'-(二硫代二乙烯)二胍；1,1-(二硫代二乙烯)二胍
• 英文名称: guanidinoethyldisulfide
• 英文别名: guanidinoethyldisulphide；N,N'''-(3,4-dithia-hexanediyl)-di-guanidine；N,N'''-(3,4-Dithia-hexandiyl)-di-guanidin；Bis-(2-guanidino-aethyl)-disulfid；2.2'-Diguanidino-diaethyldisulfid；1.1'--diguanidin；Guanidinoethyl disulfide；2-[2-[2-(diaminomethylideneamino)ethyldisulfanyl]ethyl]guanidine
• CAS: 1072-13-5
• 化学式: C₆H₁₆N₆S₂
• 分子量: 236.365
• InChiKey: IRMTXMJNHRISQH-UHFFFAOYSA-N

物化性质

• 密度：
  1.200 (estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.2
• 重原子数：
  14
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  179
• 氢给体数：
  4
• 氢受体数：
  4

安全信息

• 海关编码：
  2930909090

反应信息

• 作为产物：
  描述：

  S-(2-aminoethyl)isothiouronium bromide hydrobromide 在 sodium hydroxide 、 air 作用下， 生成 2-[2-[2-(二氨基亚甲基氨基)乙基二硫基]乙基]胍二氢溴酸盐
  参考文献：
  名称：

  Radiation-protective Agents.I. Studies on N-Alkylated-2-(2-aminoethyl)thiopseudoureas and 1, 1-(Dithioethylene)diguanidines

  摘要：

  制备了十种 N-取代的-2-(2-氨基乙基)硫代假脲类化合物（AET）。1'-Phenyl-AET (VI) 与一个当量的碱反应生成 2-氨基噻唑啉衍生物 (XXIII)，而其他在氨基氮上至少有一个氢原子的 AET 则发生分子内重排反应生成 MEG。用这些 MEG 通过温和氧化制备出 GED。此外，还讨论了这些化合物的核磁共振和红外光谱。

  DOI：

  10.1248/cpb.14.1193

文献信息

• NOVEL TETRAHYDRONAPHTHYL UREA DERIVATIVE
  申请人：MOCHIDA PHARMACEUTICAL CO., LTD.

  公开号：US20190023657A1

  公开（公告）日：2019-01-24

  The present invention aims to provide a compound having a TrkA inhibitory action, a pharmaceutically acceptable salt thereof, or a solvate thereof, a pharmaceutical composition containing the same as an active ingredient, and a preventive and/or therapeutic agent for medicinal use, in particular for a disease in which TrkA in involved (pain, cancers, inflammation/inflammatory diseases, allergic diseases, skin diseases, neurodegenerative diseases, infectious diseases, Sjogren's syndrome, endometriosis, renal diseases, osteoporosis, and the like). Specifically, the present invention provides a compound or an optical isomer thereof, a pharmaceutically acceptable salt thereof, a solvate thereof, or the like, the compound represented by formula (I):

  本发明旨在提供一种具有TrkA抑制作用的化合物，其药学上可接受的盐或其溶剂合物，以及含有其作为活性成分的药物组合物，特别用于TrkA参与的疾病（疼痛、癌症、炎症/炎症性疾病、过敏疾病、皮肤疾病、神经退行性疾病、传染病、干燥综合征、子宫内膜异位症、肾脏疾病、骨质疏松症等）的预防和/或治疗剂。具体地，本发明提供一种化合物或其光学异构体，其药学上可接受的盐、其溶剂合物或类似物，该化合物由式（I）表示：
• NANOPORE BASED SEQUENCER
  申请人：ARIZONA BOARD OF REGENTS on behalf of ARIZONA STATE UNIVERSITY

  公开号：US20170204066A1

  公开（公告）日：2017-07-20

  The present invention is directed to systems, devices and methods for identifying biopolymers, such as strands of DNA, as they pass through a constriction such as a carbon nanotube nanopore. More particularly, the invention is directed to such systems, devices and methods in which a newly translocated portion of the biopolymer forms a temporary electrical circuit between the nanotube nanopore and a second electrode, which may also be a nanotube. Further, the invention is directed to such systems, devices and methods in which the constriction is provided with a functionalized unit which, together with a newly translocated portion of the biopolymer, forms a temporary electrical circuit that can be used to characterize that portion of the biopolymer.

  本发明涉及用于识别生物聚合物（例如DNA链）的系统、设备和方法，当它们通过像碳纳米管纳孔这样的狭窄通道时。更具体地说，本发明涉及这种系统、设备和方法，其中生物聚合物的新穿过部分在纳米管纳孔和第二电极之间形成临时电路，第二电极也可能是一个纳米管。此外，本发明涉及这种系统、设备和方法，其中通道配备有一个功能化单元，该单元与生物聚合物的新穿过部分一起形成临时电路，可用于表征生物聚合物的部分。
• Pharmacological characterization of guanidinoethyldisulphide (GED), a novel inhibitor of nitric oxide synthase with selectivity towards the inducible isoform
  作者：Csaba Szabó、Ruslana Bryk、Basilia Zingarelli、Garry J. Southan、Timothy C. Gahman、Venkat Bhat、Andrew L. Salzman、Donald J. Wolff

  DOI：10.1111/j.1476-5381.1996.tb15589.x

  日期：1996.8

  potency of GED on ecNOS in the ring preparations is considerably lower than its potency against iNOS in the cultured cells. These data suggest that the selectivity of GED towards iNOS may lie, in part, at the enzyme level, as well as differential uptake by cells expressing the various isoforms of NOS. 5. In a rat model of endotoxin shock in vivo, administration of GED, at 3 mg kg-1 bolus followed by 10 mg

  1.胍，am，S-烷基异硫脲和近来巯基烷基胍已被描述为通过NO合酶（NOS）从L-精氨酸生成一氧化氮（NO）的抑制剂。我们最近证明了由巯基乙基胍（MEG）的二聚化形成的胍基乙基二硫化物（GED）是一氧化氮合酶的新型抑制剂。在这里，我们描述了GED在纯化的NOS亚型，各种培养的细胞类型，血管环制剂以及内毒素休克中的药理特性。2. GED有效抑制纯化的诱导型NOS（iNOS），内皮型NOS（ecNOS）和脑型NOS（bNOS）酶的NOS活性，Ki值分别为4.3、18和25 microM。因此，在酶水平上，GED对iNOS的选择性是ecNOS的4倍。GED对ecNOS和iNOS的抑制作用是竞争性的。L-精氨酸和非竞争性四氢生物蝶呤。3.用促炎细胞因子或细菌脂多糖的适当混合物刺激小鼠J774巨噬细胞，大鼠主动脉平滑肌细胞，鼠肺上皮细胞和人肠DLD-1细胞，以表达iNOS。在这些细胞中，GED有效抑
• [EN] INHIBITION OF OXIDATIVE STRESS, GLYCATION, AND PROTEIN CROSSLINKING<br/>[FR] INHIBITION DU STRESS OXYDANT, DE LA GLYCATION ET DE LA RÉTICULATION DE PROTÉINES
  申请人：UNIV COLORADO REGENTS

  公开号：WO2019036336A1

  公开（公告）日：2019-02-21

  Compositions for the treatment and prevention of symptoms and disease conditions associated with oxidative and carbonyl stress, including advanced glycation end products (AGEs), and to methods using the compositions. In particular, the invention relates to compositions useful in the treatment of diabetic retinopathy and nephropathy, to compositions useful in the treatment of other retinal disorders including macular degeneration and cataracts.

  用于治疗和预防与氧化和羰基应激相关的症状和疾病状态的组合物，包括高级糖基化终末产物（AGEs），以及使用这些组合物的方法。特别地，本发明涉及用于治疗糖尿病视网膜病变和肾病的组合物，用于治疗其他视网膜疾病，包括黄斑变性和白内障的组合物。
• Devices and Methods for Target Molecule Characterization
  申请人：Lindsay Stuart

  公开号：US20100084276A1

  公开（公告）日：2010-04-08

  The present invention provides a device having at least one constriction that is sized to permit translocation of only a single copy of the molecule. The device has a pair of spaced apart sensing electrodes that border the constriction, which may be a nanopore. The first electrode is connected to a first affinity element and the second electrode is connected to a second affinity element. The first and second affinity elements are configured to temporarily form hydrogen bonds with first and second portions of the target molecule as the latter passes through the constriction.

  本发明提供了一种设备，其具有至少一个狭窄部位，其尺寸仅允许单个分子的横向移动。该设备具有一对间隔的感应电极，其环绕该狭窄部位，该狭窄部位可能是纳米孔。第一电极连接第一亲和元素，第二电极连接第二亲和元素。第一和第二亲和元素被配置为在目标分子通过狭窄部位时，暂时与目标分子的第一和第二部分形成氢键。

表征谱图