2-Chloro-1,4-dimethoxy-3-methylnaphthalene | 258498-23-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-Chloro-1,4-dimethoxy-3-methylnaphthalene
• CAS: 258498-23-6
• 化学式: C₁₃H₁₃ClO₂
• 分子量: 236.698
• InChiKey: FNTONPSKHOGVEX-UHFFFAOYSA-N

物化性质

• 沸点：
  361.9±37.0 °C(Predicted)
• 密度：
  1.184±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-Chloro-1,4-dimethoxy-3-methylnaphthalene 在 ammonium cerium(IV) nitrate 作用下， 以 乙腈 为溶剂， 生成 2-氯-3-甲基萘-1,4-二酮
  参考文献：
  名称：

  2,3-Dimethoxy-5-methyl-1,4-benzoquinones and 2-methyl-1,4-naphthoquinones: glycation inhibitors with lipid peroxidation activity

  摘要：

  Anti-glycation activity of our anti-oxidant quinone library was measured and several 2,3-dimetlioxy-5-methyl-1,4-benzoquinones and 2-methyl-1,4-naphthoquinones were identified as novel inhibitors of glycation, of which 2,3-dimethoxy-5-methyl-1,4-benzoquinones 13b is the most potent glycation inhibitor with around 50 muM of the IC50 value. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.12.029
• 作为产物：
  描述：

  甲萘醌 在 palladium on activated charcoal sodium hydroxide 、 三甲基氯硅烷 、 碘苯二乙酸 、 氢气 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 生成 2-Chloro-1,4-dimethoxy-3-methylnaphthalene
  参考文献：
  名称：

  2,3-Dimethoxy-5-methyl-1,4-benzoquinones and 2-methyl-1,4-naphthoquinones: glycation inhibitors with lipid peroxidation activity

  摘要：

  Anti-glycation activity of our anti-oxidant quinone library was measured and several 2,3-dimetlioxy-5-methyl-1,4-benzoquinones and 2-methyl-1,4-naphthoquinones were identified as novel inhibitors of glycation, of which 2,3-dimethoxy-5-methyl-1,4-benzoquinones 13b is the most potent glycation inhibitor with around 50 muM of the IC50 value. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.12.029

文献信息

• [EN] ANTIPROLIFERATIVE NAPHTHOQUINONES, DERIVATIVES, COMPOSITIONS, AND USES THEREOF<br/>[FR] NAPHTOQUINONES ANTIPROLIFERATIVES, DERIVES, COMPOSITIONS ET LEURS UTILISATIONS
  申请人：UNIV PITTSBURGH

  公开号：WO2000008495A2

  公开（公告）日：2000-02-17

  The present invention provides a compound selected from the group consisting of (I), (II), and (III), wherein R?1 and R4¿ are the same or different and are each H, C¿1?-C3 alkyl, phosphate, or C1-C3 alkyl carboxylate; R?2 and R3¿ are the same or different and are each H, a halogen, A-Z, S-Z, S-A-Z, N(B)-Z, N(B)-A-Z, O-Z, or O-A-Z, wherein: A is a C¿1?-C20 linear or branched saturated or unsaturated alkyl, haloalkyl, arylalkyl, cycloalkylalkyl, heterocycloalkyl, hydroxyalkyl, alkoxyalkyl, thioalkyl, carboxyalkyl, carboalkoxyalkyl, carboxyaminoalkyl, a 5- to 6-membered ring carbohydrate or the corresponding acyclic analog thereof, peptidyl, or aminoalkyl diradical; B is H or C1-C6 alkyl; Z is H, aryl, heterocyclic, or a heteroatom-containing functional group; and R?5-R8¿ are the same or different and are each H, a halogen, heterocyclic, Z as defined above, A-Z as defined above, or heteroatom-containing functional group, provided that R5-R8 are not all H, useful as cellular growth inhibitors.
• 2,3-Dimethoxy-5-methyl-1,4-benzoquinones and 2-methyl-1,4-naphthoquinones: glycation inhibitors with lipid peroxidation activity
  作者：Young-Sik Jung、Bo-Young Joe、Sung Ju Cho、Yasuo Konishi

  DOI：10.1016/j.bmcl.2004.12.029

  日期：2005.2

  Anti-glycation activity of our anti-oxidant quinone library was measured and several 2,3-dimetlioxy-5-methyl-1,4-benzoquinones and 2-methyl-1,4-naphthoquinones were identified as novel inhibitors of glycation, of which 2,3-dimethoxy-5-methyl-1,4-benzoquinones 13b is the most potent glycation inhibitor with around 50 muM of the IC50 value. (C) 2004 Elsevier Ltd. All rights reserved.