2-胍基乙基膦酸 | 55215-15-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 中文名称: 2-胍基乙基膦酸
• 英文名称: 2-Guanidinoethylphosphonic acid
• 英文别名: 2-Guanidinoethanphosphorsaeure；2-(diaminomethylideneamino)ethylphosphonic acid
• CAS: 55215-15-1
• 化学式: C₃H₁₀N₃O₃P
• 分子量: 167.104
• InChiKey: ZLWWVZYBDRQTNN-UHFFFAOYSA-N

物化性质

• 沸点：
  403.5±55.0 °C(Predicted)
• 密度：
  1.83±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -3.1
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  122
• 氢给体数：
  4
• 氢受体数：
  4

安全信息

• 海关编码：
  2931900090

反应信息

• 作为反应物：
  描述：

  sodium dihydrogenphosphate 、 zirconyl chloride octahydrate 、 2-胍基乙基膦酸 以 水 为溶剂， 以93.9%的产率得到zirconium phosphate phosphonate monohydrate
  参考文献：
  名称：

  Preparation and catalytic property of the solid base supported on the mixed zirconium phosphate phosphonate for Knoevenagel condensation

  摘要：

  A new type of the mixed zirconium phosphate phosphonate support and the solid base were prepared and characterized by elemental analysis, IR, XRPD. P-31 MAS NMR, TG, DTG and DSC. IR spectra showed that there were some differences between the support and the solid base in the vibration frequencies. XRPD indicated that the supports were amorphous. The P-31 MAS NMR spectrum of each solid base exhibited three main resonances, and thermogravimetry indicated that the solid base had two or three step weight loss at temperatures of up 900degreesC. The Knoevenagel condensation of benzaldehyde with diethylmalonate or malononitrile, cyclohexanone, with malononitrile was catalyzed by the solid base (H_ = 12.2) in high catalytic activity and simple work-up, the catalyst could be reused four times and easy to be regenerated. (C) 2004 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molcata.2004.11.002
• 作为产物：
  描述：

  2-溴乙基膦酸二乙酯 、 胍 生成 2-胍基乙基膦酸
  参考文献：
  名称：

  Oleksyszyn,J. et al., Polish Journal of Chemistry, 1979, vol. 53, p. 2129 - 2130

  摘要：

  DOI：

文献信息

• A New Simple Route To N-Substituted 2-Aminoethylphosphonic Acids
  作者：Xiangkai Fu、Chengbin Gong、Xuebing Ma、Shuying Wen

  DOI：10.1080/00397919808004835

  日期：1998.7

  Abstract 2-Aminoethylphosphonic acid (AEPA) and its N-substituted compounds were prepared by one step reaction using 2-chloroethylphosphonic acid with ammonia and amines (H2NMe, HNMeMe, HNEtEt, H2NPr-n, H2NCH2ph, H2NCH2CH2NH2 and H2N(C=NH)NH2 in a dilute alkaline solution below 20 °C with simple work-up and easy purification. The reaction was accelerated by catalytic amount of potassium iodide. The

  摘要 采用 2-氯乙基膦酸与氨和胺（H2NMe、HNMeMe、HNEtEt、H2NPr-n、H2NCH2ph、H2NCH2CH2NH2 和 H2N(C=NH)）通过一步反应制备了 2-氨基乙基膦酸 (AEPA) 及其 N-取代化合物。 NH2在20℃以下的稀碱溶液中，后处理简单，易于纯化。催化量的碘化钾加速反应。反应产物的收率为35.6%～48.6%（不存在KI），78.2%～88.0%对于 KI 的存在。
• Cameron, David G.; Hudson, Harry R.; Pianka, Max, Phosphorus, Sulfur and Silicon and the Related Elements, 1993, vol. 83, # 1-4, p. 21 - 38
  作者：Cameron, David G.、Hudson, Harry R.、Pianka, Max

  DOI：——

  日期：——
• Oleksyszyn,J. et al., Polish Journal of Chemistry, 1979, vol. 53, p. 2129 - 2130
  作者：Oleksyszyn,J. et al.

  DOI：——

  日期：——
• Preparation and catalytic property of the solid base supported on the mixed zirconium phosphate phosphonate for Knoevenagel condensation
  作者：RenQuan Zeng、XiangKai Fu、ChengBin Gong、Yan Sui、XueBing Ma、XinBin Yang

  DOI：10.1016/j.molcata.2004.11.002

  日期：2005.3

  A new type of the mixed zirconium phosphate phosphonate support and the solid base were prepared and characterized by elemental analysis, IR, XRPD. P-31 MAS NMR, TG, DTG and DSC. IR spectra showed that there were some differences between the support and the solid base in the vibration frequencies. XRPD indicated that the supports were amorphous. The P-31 MAS NMR spectrum of each solid base exhibited three main resonances, and thermogravimetry indicated that the solid base had two or three step weight loss at temperatures of up 900degreesC. The Knoevenagel condensation of benzaldehyde with diethylmalonate or malononitrile, cyclohexanone, with malononitrile was catalyzed by the solid base (H_ = 12.2) in high catalytic activity and simple work-up, the catalyst could be reused four times and easy to be regenerated. (C) 2004 Elsevier B.V. All rights reserved.