ethyl β-[4-(2-aminoethyl)-phenyl]-propionate hydrochloride | 61629-90-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl β-[4-(2-aminoethyl)-phenyl]-propionate hydrochloride
• 英文别名: ethyl 3-[4-(2-aminoethyl)-phenyl]-propionate hydrochloride；Ethyl 3-[4-(2-aminoethyl)phenyl]propanoate;hydrochloride
• CAS: 61629-90-1
• 化学式: C₁₃H₁₉NO₂*ClH
• 分子量: 257.76
• InChiKey: GVTGITXWTNFZMS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.11
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  52.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  ethyl β-[4-(2-aminoethyl)-phenyl]-propionate hydrochloride 在 氢氧化钾 、 sodium hydroxide 作用下， 以 乙醇 为溶剂， 生成 3-(3-{4-[2-(2-9H-Fluoren-9-yl-acetylamino)-ethyl]-phenyl}-propionylamino)-propionic acid
  参考文献：
  名称：

  FR2356631

  摘要：

  公开号：

文献信息

• Hypoglycaemically and hypolipidaemically effective n-substituted
  申请人：Boehringer Mannheim GmbH

  公开号：US04136197A1

  公开（公告）日：1979-01-23

  An N-substituted carboxylic acid amide of the formula ##STR1## wherein A is a valency bond or an oxygen or sulphur atom or a methylene, ethylene, vinylene, ethyleneoxa or ethylenethia radical, V is a trivalent hydrocarbon radical containing up to 4 carbon atoms, R.sub.1 and R.sub.2 each independently is hydrogen, a halogen atom, a hydroxyl group or an alkyl or alkoxy radical, R.sub.3 is hydrogen, a hydroxyl group or an alkoxy radical, Y is an alkylene radical containing up to 3 carbon atoms, X is a valency bond or a divalent aliphatic hydrocarbon radical containing up to 6 carbon atoms, and D is a hydroxymethyl, formyl, free or esterified carboxyl or an N-substituted carbamoyl radical, or a physiologically compatible salt thereof, characterized by hypoglycaemic and hypolipidaemic activity.

  一种具有降糖和降脂活性的公式为##STR1##的N-取代羧酸酰胺，其中A是一个价键或一个氧或硫原子或一个亚甲基、乙烯基、乙烯基、乙烯氧基或乙烯硫基团，V是一个含有最多4个碳原子的三价碳氢基团，R.sub.1和R.sub.2分别独立地是氢、卤原子、羟基或烷基或烷氧基基团，R.sub.3是氢、羟基或烷氧基基团，Y是一个含有最多3个碳原子的烷基基团，X是一个价键或含有最多6个碳原子的二价脂肪烃基团，D是一个羟甲基、甲酰基、自由或酯化羧基或一个N-取代的氨基甲酰基团，或其生理兼容盐。
• Sulphonamidophenylcarboxylic acid compounds and pharmaceutical
  申请人：Boehringer Mannheim GmbH

  公开号：US04443477A1

  公开（公告）日：1984-04-17

  The invention provides sulphonamides of the formula ##STR1## wherein R is a hydrogen atom or a lower alkyl radical; R.sub.1 is alkyl, aryl, aralkyl or aralkenyl, the aryl moiety of which in each case can be optionally substituted one or more times by hydroxyl, halogen, trifluoromethyl, lower alkyl or alkoxy or by acyl, carboxy or alkoxycarbonyl; n is 1, 2 or 3; and W is a valence bond or a divalent aliphatic hydrocarbon linkage and the physiologically acceptable salts, esters and amides of such compound. These compounds have excellent pharmacological lipid depressing activity and inhibit thrombocyte aggregation.

  该发明提供了以下结构的磺胺类化合物：##STR1## 其中R为氢原子或低碳基基团；R.sub.1为烷基、芳基、芳基烷基或芳基烯基，其中每种情况下的芳基部分可以选择性地通过羟基、卤素、三氟甲基、低碳基或烷氧基或酰基、羧基或烷氧羰基取代一次或多次；n为1、2或3；W为价键或二价脂肪族碳链，以及该化合物的生理学上可接受的盐、酯和酰胺。这些化合物具有出色的药理学降脂活性，并抑制血小板聚集。
• Hypoglycemically and hypolipidemically active derivatives of
  申请人：Boehringer Mannheim GmbH

  公开号：US04113871A1

  公开（公告）日：1978-09-12

  Phenyl-alkane-carboxylic acids of the formula ##STR1## wherein A is an aryl, aralkyl or arylvinyl radical optionally substituted by hydroxy, halogen, trifluoromethyl, alkyl, alkylthio, alkoxy, alkenyloxy, alkoxyalkoxy, alkyl-substituted amino, aryloxy or alkoxy-substituted aryloxy, or is an aryloxyalkyl or arylthioalkyl radical, or a heterocyclic ring system optionally substituted by halogen, alkyl or alkoxy, Y is a valency bond or an unbranched or branched lower alkylene radical containing up to 3 carbon atoms, X is a straight or branched, saturated or unsaturated divalent aliphatic hydrocarbon radical containing 2 to 8 carbon atoms, there being at least 2 carbon atoms between the benzene ring and the carboxyl group, and R is a hydrogen atom or a lower alkyl radical, as well as physiologically compatible salts, esters and amides thereof, exhibit hypoglycaemic and hypolipidaemic activity.

  公式为##STR1##的苯基-烷基-羧酸，其中A为一芳基、芳基烷基或芳基乙烯基基团，可选择性地被羟基、卤素、三氟甲基、烷基、烷硫基、烷氧基、烯氧基、烷氧基烷基、烷基取代的氨基、芳氧基或烷氧基取代的芳氧基取代，或为芳氧基烷基或芳硫基烷基基团，或可选择性地被卤素、烷基或烷氧基取代的杂环环系统；Y为一个价键或一个含有最多3个碳原子的直链或支链低级烷基基团；X为一直链或支链、饱和或不饱和的双价脂肪族碳氢基团，含有2到8个碳原子，苯环和羧基之间至少有2个碳原子；R为氢原子或低级烷基基团。以及其生理兼容的盐、酯和酰胺具有降血糖和降血脂活性。
• Hypoglycaemically and hypolipidaemically active derivatives of
  申请人：Boehringer Mannheim GmbH

  公开号：US04238506A1

  公开（公告）日：1980-12-09

  Phenyl-alkane-carboxylic acids of the formula ##STR1## wherein A is an aryl, aralkyl or arylvinyl radical optionally substituted by hydroxy, halogen, trifluoromethyl, alkyl, alkylthio, alkoxy, alkenyloxy, alkoxyalkoxy, alkyl-substituted amino, aryloxy or alkoxy-substituted aryloxy, or is an aryloxyalkyl or arylthioalkyl radical, or a heterocyclic ring system optionally substituted by halogen, alkyl or alkoxy, Y is a valency bond or an unbranched or branched lower alkylene radical containing up to 3 carbon atoms, X is a straight or branched, saturated or unsaturated divalent aliphatic hydrocarbon radical containing 2 to 8 carbon atoms, there being at least 2 carbon atoms between the benzene ring and the carboxyl group, and R is a hydrogen atom or a lower alkyl radical, as well as physiologically compatible salts, esters and amides thereof, exhibit hypoglycaemic and hypolipidaemic activity.

  公式为##STR1##其中，A是芳基、芳基烷基或芳基乙烯基基团，可选择地由羟基、卤素、三氟甲基、烷基、烷硫基、烷氧基、烯氧基、烷氧基烷氧基、烷基取代的氨基、芳氧基或烷氧基取代的芳氧基取代，或芳氧基烷基或芳硫烷基基团，或可选择地由卤素、烷基或烷氧基取代的杂环环系统；Y是一个价键或一个含有最多3个碳原子的直链或支链低级烷基基团；X是一个直链或支链、饱和或不饱和的双价脂肪族碳氢基团，含有2到8个碳原子，在苯环和羧基之间至少有2个碳原子；R是氢原子或低级烷基基团。这些化合物及其生理相容的盐、酯和酰胺具有降血糖和降血脂作用。
• DE2629752
  申请人：——

  公开号：——

  公开（公告）日：——