1,5,9,13-tetraazacyclohexadecane | 24772-41-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1,5,9,13-tetraazacyclohexadecane
• 英文别名: 1,4,8,12-tetraazacyclopentadecane；1,5,9,13-tetraazazcyclohexadecane；1,5,8,13-tetraazacyclohexadecane；cyclam；1,5,9,13-tetraaza-cyclohexadecane；[16]aneN4；1,5,9,13-tetrazacyclohexadecane
• CAS: 24772-41-6
• 化学式: C₁₂H₂₈N₄
• 分子量: 228.381
• InChiKey: YXPRJLINFVQPDT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  48.1
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,5,9,13-tetraazacyclohexadecane 在 三(二甲胺基)膦 作用下， 生成 1,5,9,13-Tetraaza-17-phosphatricyclo[7.7.1.05.17 ]heptadecane
  参考文献：
  名称：

  Tricyclic phosphorous triamides

  摘要：

  多环磷三酰胺的化学式为##STR1##，其中R.sup.1和R.sup.2，相同或不同，是2到约6个碳原子的烷基；R.sup.3和R.sup.4，相同或不同，是1到约8个碳原子的烷基，5到约8个碳原子的环烷基，或芳基烷基，其中芳基含有6到约12个碳原子，烷基含有1到约8个碳原子；或者R.sup.3和R.sup.4相互连接形成一个2到约6个碳原子的烷基，该烷基可以被1.一个##STR2##基团（其中Q是氢或1到约18个碳原子的烷基）或2.一个或两个--O--键连接所中断；在外环系统中，每两个异原子之间至少有2个碳原子，当三酰胺为三环时，连接到磷的氮原子之间的链中至少有一个含有至少三个原子。这些化合物可用作棉花的阻燃剂。

  公开号：

  US04038312A1
• 作为产物：
  描述：

  在 氨 、 sodium 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 生成 1,5,9,13-tetraazacyclohexadecane
  参考文献：
  名称：

  Triflamides for protection and cyclization of tetraamines to tetraazamacrocycles

  摘要：

  A facile two-step synthesis of tetraazamacrocycles is reported starting from trifluoromethanesulfonyl derivatives of linear tetraamines. After cyclization, the macrocycle was deprotected using sodium in liquid ammonia.

  DOI：

  10.1016/s0040-4039(00)61129-2

文献信息

• Methods of preparing manganese complexes of nitrogen-containing
  申请人：Monsanto Company

  公开号：US05610293A1

  公开（公告）日：1997-03-11

  The present invention is directed to low molecular weight mimics of superoxide dismutase (SOD) represented by the formula: ##STR1## wherein R, R', R.sub.1, R'.sub.1, R.sub.2, R'.sub.2, R.sub.3, R'.sub.3, R.sub.4, R'.sub.4, R.sub.5, R'.sub.5, R.sub.6, R'.sub.6, R.sub.7, R'.sub.7, R.sub.8, R'.sub.8, R.sub.9, and R'.sub.9 and X, Y, Z and n are as defined herein, useful as therapeutic agents for inflammatory disease states and disorders, ischemic/reperfusion injury, stroke, atherosclerosis, hypertension and all other conditions of oxidant-induced tissue damage or injury.

  本发明涉及超氧化物歧化酶（SOD）的低分子量模拟物，其化学式如下：##STR1## 其中R、R'、R₁、R'₁、R₂、R'₂、R₃、R'₃、R₄、R'₄、R₅、R'₅、R₆、R'₆、R₇、R'₇、R₈、R'₈、R₉和R'₉以及X、Y、Z和n的定义如本文所述，可用作治疗炎症性疾病状态和紊乱、缺血/再灌注损伤、中风、动脉粥样硬化、高血压和所有其他由氧化剂引起的组织损伤或损伤的条件。
• Manganese complexes of nitrogen-containing macrocyclic ligands effective
  申请人：G. D. Searle & Co.

  公开号：US05874421A1

  公开（公告）日：1999-02-23

  The present invention is directed to low molecular weight mimics of superoxide dismutase (SOD) represented by the formula: ##STR1## wherein R, R', R.sub.1, R'.sub.1, R.sub.2, R'.sub.2, R.sub.3, R'.sub.3, R.sub.4, R'.sub.4, R.sub.5, R'.sub.5, R.sub.6, R'.sub.6, R.sub.7, R'.sub.7, R.sub.8, R'.sub.8, R.sub.9, and R'.sub.9 and X, Y, Z and n are as defined herein, useful as therapeutic agents for inflammatory disease states and disorders, ischemic/reperfusion injury, stroke, atherosclerosis, hypertension and all other conditions of oxidant-induced tissue damage or injury.

  本发明涉及超氧化物歧化酶（SOD）的低分子量模拟物，其化学式为：##STR1## 其中R、R'、R₁、R'₁、R₂、R'₂、R₃、R'₃、R₄、R'₄、R₅、R'₅、R₆、R'₆、R₇、R'₇、R₈、R'₈、R₉和R'₉以及X、Y、Z和n的定义如本文所述，可用作治疗炎症性疾病状态和紊乱、缺血/再灌注损伤、中风、动脉粥样硬化、高血压和所有其他由氧化剂引起的组织损伤或损伤的条件的治疗剂。
• Zinc complexes of four tetra-aza macrocycles: enthalpies of formation in acetonitrile solution
  作者：Douglas P. Graddon、Mauro Micheloni、Piero Paoletti

  DOI：10.1039/dt9810000336

  日期：——

  ionised when the four N atoms of the base are methylated. In the presence of an excess of ZnBr2 all the bases form [ZnBr(base)]-[ZnBr3]. Enthalpies of formation of the complexes are smaller for the 14-membered macrocycle (‘cyclam’) than for the 15- and 16-membered and are similar for methylated and unmethylated cyclam. The results support five-co-ordinated structures for the complex ions, in which the

  四个四氮杂大环化合物，-1,4,8,12-四azacyclotetradecane，-1,4,8,12-四azacyclopentadecane，1,5,9,13四azacyclohexadecane，并且反应NN ' Ñ “对乙腈溶液中的ZnBr 2和[ZnBr 2（py）2 ]（py =吡啶）的N ‴-四甲基-1,4,8,11-四氮杂环十四烷进行了电导和量热研究，并分离了各种配合物。在碱和ZnBr 2或[ZnBr 2（py）2 ]相等的情况下，反应产物为[ZnBr 2的平衡混合物。（碱）]和[ZnBr（碱）] Br，但是当碱的四个N原子被甲基化时会被完全离子化。在过量的ZnBr 2存在下，所有碱形成[ZnBr（碱）]-[ZnBr 3 ]。14元大环（'cyclam'）的复合物形成焓小于15元和16元大环，并且对于甲基化和未甲基化的cyclam相似。结果支持复合离子的五配位结构，其中大环
• Complexes of cyclic polyaza chelators with cations of alkaline earth metals for enhanced biological activity
  申请人：Winchell S. Harry

  公开号：US20050112066A1

  公开（公告）日：2005-05-26

  Cyclic polyaza chelators that possess high affinity and specificity for first transition series metal cations exhibit an unanticipated improvement in biological activity when administered as complexes with cations of the alkaline earth metals, Ca(II) and Mg(II), most notably Ca(II). By virtue of this improvement, these complexes are particularly effective in the treatment of pathological conditions, including ischemia and ischemia-reperfusion injury.

  具有高亲和力和特异性的环状多氮螯合剂，当与碱土金属阳离子的络合物一起给药时，表现出生物活性的意外改善，其中以Ca(II)和Mg(II)的络合物最为显著，尤其是Ca(II)。由于这种改善，这些络合物在治疗病理条件，包括缺血和缺血再灌注损伤方面特别有效。
• METHOD FOR MANUFACTURING NITROGEN-CONTAINING CARBON ALLOY, NITROGEN-CONTAINING CARBON ALLOY, AND FUEL CELL CATALYST
  申请人：FUJIFILM Corporation

  公开号：US20150376218A1

  公开（公告）日：2015-12-31

  Provided is a method for manufacturing a nitrogen-containing carbon alloy having a sufficiently high oxygen reduction reaction activity, a nitrogen-containing carbon alloy, and a fuel cell catalyst. The method for manufacturing a nitrogen-containing carbon alloy comprises sintering a precursor which contains a nitrogen-containing compound and an inorganic metal salt, the nitrogen-containing compound having at least one heteroaromatic ring and a conjugated heterocycle, and the conjugated heterocycle having 12 or larger number of ring-forming atoms.

  提供了一种制造具有足够高氧还原反应活性的含氮碳合金的方法，一种含氮碳合金和燃料电池催化剂。制造含氮碳合金的方法包括烧结含有含氮化合物和无机金属盐的前体，其中含氮化合物至少含有一个杂芳环和一个共轭杂环，共轭杂环具有12个或更多个环形原子。