thiophene-2-carbaldehyde sulphaguanidine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: thiophene-2-carbaldehyde sulphaguanidine
• 英文别名: N-carbamimidoyl-4-{[(E)-thiophen-2-ylmethylidene]amino}benzenesulfonamide；2-[4-(thiophen-2-ylmethylideneamino)phenyl]sulfonylguanidine
• 化学式: C₁₂H₁₂N₄O₂S₂
• mdl: MFCD01990155
• 分子量: 308.385
• InChiKey: CNIUPTSUFBJHMY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  148
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  二乙氧基二甲基硅烷 、 thiophene-2-carbaldehyde sulphaguanidine 以 苯 为溶剂， 反应 6.0h， 生成 1-[[Carbamimidoyl-[4-(thiophen-2-ylmethylideneamino)phenyl]sulfonylamino]-dimethylsilyl]-1-[4-(thiophen-2-ylmethylideneamino)phenyl]sulfonylguanidine
  参考文献：
  名称：

  SYNTHETIC, SPECTRAL AND BIOLOGICAL STUDIES OF ORGANOSILICON (IV) COMPLEXES WITH SCHIFF BASES OF SULFA DRUGS

  摘要：

  In the present paper synthetic and structural studies of six-coordinated Me2Si(NN)(2) type of organosilicon(IV) complexes of Schiff bases (NN) have been described. The complexes were characterized by elemental analyses, conductance measurements, molecular weight determinations and electronic, infrared, H-1, C-13 and Si-29 NMR spectral studies. A few representative complexes were also screened for antimicrobial activity and found to be quite active in this respect.

  DOI：

  10.1080/10426500008042104
• 作为产物：
  描述：

  2-噻吩甲醛 、 磺胺脒 以 乙醇 为溶剂， 以92%的产率得到thiophene-2-carbaldehyde sulphaguanidine
  参考文献：
  名称：

  一些新型有机硅（IV）与磺胺类药物席夫碱的配位化合物

  摘要：

  通过二苯基二氯硅烷与希夫碱合成了新的有机硅 (IV) 六配位配合物，席夫碱源自杂环酮和醛与一系列磺胺药物的缩合。它们的结构是根据元素分析、UV、IR 和 NMR 光谱研究推断出来的。这些化合物的单体和非电解性质已通过分子量测定和电导测量得到证实。席夫碱及其硅配合物也已被筛选出对几种真菌和细菌的抗微生物活性，并发现在这方面非常活跃。

  DOI：

  10.1080/10426500307802

文献信息

• Some New Coordination Compounds of Organosilicon(IV) with Schiff Bases of Sulpha Drugs
  作者：M. Sharma、H. L. Singh、S. Varshney、P. Sharma、A. K. Varshney

  DOI：10.1080/10426500307802

  日期：2003.4

  New hexa-coordinated complexes of organosilicon(IV) have been synthesized by the diphenyldichlorosilane with the Schiff bases derived from the condensation of heterocyclic ketones and aldehydes with a series of sulpha drugs. Their structures have been inferred on the basis of elemental analysis, UV, IR, and NMR spectral studies. The monomeric and nonelectrolytic nature of these compounds have been

  通过二苯基二氯硅烷与希夫碱合成了新的有机硅 (IV) 六配位配合物，席夫碱源自杂环酮和醛与一系列磺胺药物的缩合。它们的结构是根据元素分析、UV、IR 和 NMR 光谱研究推断出来的。这些化合物的单体和非电解性质已通过分子量测定和电导测量得到证实。席夫碱及其硅配合物也已被筛选出对几种真菌和细菌的抗微生物活性，并发现在这方面非常活跃。
• Gupta; Singh; Tripaathi, Bulletin of the Polish Academy of Sciences: Chemistry, 2000, vol. 48, # 3, p. 195 - 201
  作者：Gupta、Singh、Tripaathi、Varshney

  DOI：——

  日期：——
• SYNTHETIC, SPECTRAL AND BIOLOGICAL STUDIES OF ORGANOSILICON (IV) COMPLEXES WITH SCHIFF BASES OF SULFA DRUGS
  作者：A. K. Varshney、S. Varshney、Madhulika Sharma、H. L. Singh

  DOI：10.1080/10426500008042104

  日期：2000.6.1

  In the present paper synthetic and structural studies of six-coordinated Me2Si(NN)(2) type of organosilicon(IV) complexes of Schiff bases (NN) have been described. The complexes were characterized by elemental analyses, conductance measurements, molecular weight determinations and electronic, infrared, H-1, C-13 and Si-29 NMR spectral studies. A few representative complexes were also screened for antimicrobial activity and found to be quite active in this respect.
• SYNTHETIC, STEREOCHEMICAL, AND BIOLOGICAL ASPECTS OF MANGANESE (II) COMPLEXES WITH UNSYMMETRICAL SULFUR CONTAINING BIDENTATE SCHIFF BASES
  作者：R. V. Singh、S. C. Joshi、Rakhi Dwivedi

  DOI：10.1080/10426500490274664

  日期：2004.2.1

  The synthesis and characterization of tetracoordinated manganese (II) complexes of unsymmetrical sulpha drug azomethines having general formula ((MnLL2)-L-1,) are reported. The 1:1:1 reactions of hydrated manganese chloride with unsymmetrical monobasic bidentate azomethines resulted in the formation of coloured solids. The complexes have been characterized by elemental analysis, molecular weight determinations, magnetic measurements, IR, ESR, and UV spectral studies. The magnetic and spectral studies indicate tetrahedral geometry for the resulting complexes. The ligands along with their complexes have,been screened in vitro against a number of pathogenic fungal and bacterial strains. The antifertility activity of some representative ligands and their manganese complexes have been studied and important parameters like testicular biochemistry, sperm dynamics, and reproductive organ weights have been discussed. The studies indicate that the metal chelates are more potent than the parent ligands.