N-(6-aminopyridin-2-yl) stearamide

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-(6-aminopyridin-2-yl) stearamide
• 英文别名: N-(6-aminopyridin-2-yl)octadecanamide
• 化学式: C₂₃H₄₁N₃O
• 分子量: 375.598
• InChiKey: BEMLXHNGKJWJGE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.4
• 重原子数：
  27
• 可旋转键数：
  17
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.74
• 拓扑面积：
  68
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  D-葡萄糖 、 N-(6-aminopyridin-2-yl) stearamide 在 borane dimethylamine complex 作用下， 以 吡啶 、 溶剂黄146 为溶剂， 反应 2.5h， 生成 N-[6-[[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]amino]pyridin-2-yl]octadecanamide
  参考文献：
  名称：

  Lipid-Based Nanotubes as Functional Architectures with Embedded Fluorescence and Recognition Capabilities

  摘要：

  A limited combinatorial strategy was used to synthesize a small library of soft lipid-based materials ranging from structurally unordered fibers to highly uniform nanotubes. The latter nanotubes are comprised of a bilayer structure with interdigitated alkyl chains associated through hydrophobic interactions. These tubes contain accessible 2,6-diaminopyridine linkers that can interact with thymidine and related nucleosides through multipoint hydrogen bonding, thereby quenching the intrinsic fluorescence of the aromatic linker. These results are the first example of a systematic strategy to design functional lipid nanotubes with precise structural and functional features.

  DOI：

  10.1021/ja0446449
• 作为产物：
  描述：

  2,6-二氨基吡啶 、 硬脂酸 在 nano sulfated-TiO₂ 作用下， 115.0 ℃ 、101.33 kPa 条件下， 反应 6.0h， 以50%的产率得到N-(6-aminopyridin-2-yl) stearamide
  参考文献：
  名称：

  Nano Sulfated Titania as Solid Acid Catalyst in Direct Synthesis of Fatty Acid Amides

  摘要：

  Nanosized sulfated titania was prepared by a sol gel hydrothermal process. X-ray diffraction (XRD), transmission electron, and scanning electron micrographs (TEM and SEM), FT-IR specific surface area, and BET N(2) adsorption were employed to characterize the properties of the synthesized sulfated TiO(2). The results indicate that both anatase and rutile TiO(2) are obtainable. This prepared sulfated titania showed high catalytic activity in direct amidation of fatty acids as well as benzoic acids with various amines under solvent-free conditions.

  DOI：

  10.1021/jo2002769

文献信息

• Nano Sulfated Titania as Solid Acid Catalyst in Direct Synthesis of Fatty Acid Amides
  作者：Mona Hosseini-Sarvari、Esmat Sodagar、Mohammad Mahdi Doroodmand

  DOI：10.1021/jo2002769

  日期：2011.4.15

  Nanosized sulfated titania was prepared by a sol gel hydrothermal process. X-ray diffraction (XRD), transmission electron, and scanning electron micrographs (TEM and SEM), FT-IR specific surface area, and BET N(2) adsorption were employed to characterize the properties of the synthesized sulfated TiO(2). The results indicate that both anatase and rutile TiO(2) are obtainable. This prepared sulfated titania showed high catalytic activity in direct amidation of fatty acids as well as benzoic acids with various amines under solvent-free conditions.
• Lipid-Based Nanotubes as Functional Architectures with Embedded Fluorescence and Recognition Capabilities
  作者：George John、Megan Mason、Pulickel M. Ajayan、Jonathan S. Dordick

  DOI：10.1021/ja0446449

  日期：2004.11.1

  A limited combinatorial strategy was used to synthesize a small library of soft lipid-based materials ranging from structurally unordered fibers to highly uniform nanotubes. The latter nanotubes are comprised of a bilayer structure with interdigitated alkyl chains associated through hydrophobic interactions. These tubes contain accessible 2,6-diaminopyridine linkers that can interact with thymidine and related nucleosides through multipoint hydrogen bonding, thereby quenching the intrinsic fluorescence of the aromatic linker. These results are the first example of a systematic strategy to design functional lipid nanotubes with precise structural and functional features.