benzofuran-2,3-dione 2-[O-(2-hydroxy-ethyl)-oxime]3-(O-methyl-oxime) | 200419-33-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 香豆素
• 英文名称: benzofuran-2,3-dione 2-[O-(2-hydroxy-ethyl)-oxime]3-(O-methyl-oxime)
• 英文别名: benzofuran-2,3-dione 2-[O-(2-hydroxy-ethyl)-oxime] 3-(O-methyl-oxime)；benzofuran-2,3-dione 2-[O-(2hydroxy-ethyl) oxime]-3-(O-methyl oxime)；benzofurane-2,3-dione 2-[O-(2-hydroxyethyl)oxime] 3-(O-methyloxime)；O-hydroxyethyl-O'-methyl-benzofurandione dioxime；2,3-Benzofurandione, 2-[O-(2-hydroxyethyl)oxime] 3-(O-methyloxime)；2-[(3-methoxyimino-1-benzofuran-2-ylidene)amino]oxyethanol
• CAS: 200419-33-6
• 化学式: C₁₁H₁₂N₂O₄
• 分子量: 236.227
• InChiKey: SEFNAZMOZPAYKB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  72.6
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  benzofuran-2,3-dione 2-[O-(2-hydroxy-ethyl)-oxime]3-(O-methyl-oxime) 在 乙醚 、 盐酸 作用下， 以 乙醚 、 盐酸 为溶剂， 反应 1.0h， 以In total, 1.37 g (69% of theory) of (5,6-dihydro-1,4,2-dioxazin-3-yl)-(2-hydroxy-phenyl)-methanone O-methyl-oxime (1) are obtained (content according to HPLC analysis: 97.59%)的产率得到(E)-(5,6-dihydro-[1,4,2]dioxazin-3-yl)-(2-hydroxyphenyl)-methanone O-methyloxime
  参考文献：
  名称：

  Process for preparing 3-(1-hydroxyphenyl-1-alkoximinomethyl) dioxazines

  摘要：

  制备3-(1-羟基苯基-1-烷氧基亚甲基)二氧杂环己烷的过程。本发明涉及一种制备3-(1-羟基苯基-1-烷氧基亚甲基)二氧杂环己烷的多种新工艺和新中间体，该中间体已知为制备具有杀菌性质的化合物的中间体（WO 95-04728）。

  公开号：

  US20020169316A1
• 作为产物：
  描述：

  2-(3-methoxyimino-3H-benzofuran-2-ylidenaminooxy)ethyl acetate 在 sodium hydroxide 作用下， 以 DMF (N,N-dimethyl-formamide) 为溶剂， 反应 16.0h， 以67.6%的产率得到benzofuran-2,3-dione 2-[O-(2-hydroxy-ethyl)-oxime]3-(O-methyl-oxime)
  参考文献：
  名称：

  Zwischenprodukte zur Herstellung von 3-(1-Hydroxyphenyl-1-alkoximinomethyl)dioxazinen

  摘要：

  公开号：

  EP1188753B1

文献信息

• Methoximinomethyloxadiazines
  申请人：Bayer Aktiengesellschaft

  公开号：US06251899B1

  公开（公告）日：2001-06-26

  A compound of the formula (I) wherein Z represents a moiety selected from the group consisting of cycloalkyl having 3 to 7 carbon atoms in the cycloalkyl moiety or cycloalkylalkyl having 3 to 7 carbon atoms in the cycloalkyl moiety and 1 to 4 carbon atoms in the alkyl moiety, with said cycloalkyl or cycloalkylalkyl being in each case optionally mono- to pentasubstituted by halogen or alkyl; a heterocyclyl group selected from the group consisting of thienyl, pyridyl, furyl, thienylmethyl, pyridylmethyl or furylmethyl, each of which is optionally substituted by halogen, dialkylamino or alkyl having 1 to 4 carbon atoms; an aryl or arylalkyl having in each case 6 to 10 carbon atoms in the aryl moiety and 1 to 4 carbon atoms in Q represents oxygen or sulphur, X represents halogen and The compositions have microbicidal activity.

  式（I）的化合物 其中 Z代表从环烷基中选择的基团，所述环烷基在环烷基基团中具有3至7个碳原子，或者从环烷基烷基中选择的基团，所述环烷基在环烷基基团中具有3至7个碳原子，在烷基基团中具有1至4个碳原子，所述环烷基或环烷基烷基在每种情况下均可选择地经过卤素或烷基的单取代至五取代； 从噻吩基、吡啶基、呋喃基、噻吩甲基、吡啶甲基或呋喃甲基中选择的杂环基团，每种基团均可选择地经过卤素、二烷基胺或具有1至4个碳原子的烷基取代； 在每种情况下，芳基或芳基烷基，所述芳基基团中具有6至10个碳原子，在 Q代表氧或硫， X代表卤素 这些组合物具有杀菌活性。
• Method for preparing optionally substituted benzofuranones
  申请人：Bayer Aktiengesellschaft

  公开号：US06194590B1

  公开（公告）日：2001-02-27

  The invention relates to an improved method for preparing optionally substituted benzofuran-3-ones which can be used as initial products for preparing 3-(1-hydroxyphenyl-1-alkoximinomethyl) dioxazines. These later are known starting materials for preparing compounds with fungicidal properties.

  该发明涉及一种改进的方法，用于制备可选择取代的苯并呋喃-3-酮，可用作制备3-(1-羟基苯基-1-烷氧基亚甲基)二氧杂吡嗪的初始产品。这些后者是已知的用于制备具有杀真菌性能的化合物的起始物质。
• Process for preparing 3-(1-hydroxphenyl-1-alkoximinomethyl)dioxazines
  申请人：Bayer Aktiengesellschaft

  公开号：US06335454B1

  公开（公告）日：2002-01-01

  The present invention relates to a novel process for preparing 3-(1-hydroxyphenyl-1-alkoximinomethyl)dioxazines which are known as intermediates for preparing compounds having fungicidal properties (WO 95-04728). Furthermore, the invention relates to novel 3-(1-hydroxyphenyl-1-alkoximinomethyl)dioxazines, to novel intermediates for their preparation and to a plurality of processes for preparing the novel intermediates.

  本发明涉及一种新型制备3-(1-羟基苯基-1-烷氧基亚甲基)二氧杂噁唑的方法，该方法被用作制备具有杀真菌性质的化合物的中间体（WO 95-04728）。此外，该发明涉及新型3-(1-羟基苯基-1-烷氧基亚甲基)二氧杂噁唑，用于其制备的新型中间体，以及制备这些新型中间体的多种方法。
• Process for preparing 3-(1-hydroxyphenyl-1-alkoximinomethyl)dioxazines
  申请人：——

  公开号：US20020049319A1

  公开（公告）日：2002-04-25

  The present invention relates to a novel process for preparing 3-(1-hydroxyphenyl-1-alkoximinomethyl)dioxazines which are known as intermediates for preparing compounds having fungicidal properties (WO 95-04728). Furthermore, the invention relates to novel 3-(1-hydroxyphenyl-1-alkoximinomethyl)dioxazines, to novel intermediates for their preparation and to a plurality of processes for preparing the novel intermediates.

  本发明涉及一种制备3-(1-羟基苯基-1-烷氧基亚甲基)二氧杂环己烷的新工艺，该化合物是制备具有杀菌性质的化合物的中间体（WO 95-04728）。此外，本发明还涉及新的3-(1-羟基苯基-1-烷氧基亚甲基)二氧杂环己烷、制备它们的新中间体以及多种制备新中间体的工艺。
• Processes for preparing 3-(1-hydroxyphenyl-1-alkoximinomethyl) dioxazines
  申请人：Bayer Aktiengesellschaft

  公开号：US06479675B1

  公开（公告）日：2002-11-12

  The present invention relates to a plurality of novel processes and novel intermediates for preparing 3-(1-hydroxyphenyl-1-alkoximinomethyl)dioxazines, which are known as intermediates for preparing compounds having fungicidal properties (WO 95-04728).

  本发明涉及多种新型工艺和新型中间体，用于制备3-(1-羟基苯基-1-烷氧基亚甲基)二氧杂环己烷，该化合物是制备具有杀菌性能的化合物的中间体（WO 95-04728）。