A Protocol for the <i>Ortho</i>-Deuteration of Acidic Aromatic Compounds in D<sub>2</sub>O Catalyzed by Cationic Rh<sup>III</sup>
作者:Alyssa L. Garreau、Hanyang Zhou、Michael C. Young
DOI:10.1021/acs.orglett.9b02618
日期:2019.9.6
catalytically introduce deuterium in synthetically useful yields ortho to a carboxylic acid directing group on arenes typically requires D2 or high catalyst loadings, which makes using these approaches cost prohibitive for large-scale synthesis (equipment and reagent costs respectively). Herein, we present a simplified approach using low catalyst loadings of cationic RhIII and D2O as both deuterium source and solvent