(3S,5E,7E,10R)-9,10-seco-ergosta-5,7,22t-trien-3-ol | 65377-91-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: (3S,5E,7E,10R)-9,10-seco-ergosta-5,7,22t-trien-3-ol
• 英文别名: (1S,3E,4R)-3-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5R)-5,6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylcyclohexan-1-ol
• CAS: 65377-91-5
• 化学式: C₂₈H₄₆O
• 分子量: 398.673
• InChiKey: ILYCWAKSDCYMBB-AJMJHPOFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  维生素D2 在 二氯二茂钛 、 lithium aluminium tetrahydride 、 碘 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 反应 5.0h， 生成 (3S,5E,7E,10R)-9,10-seco-ergosta-5,7,22t-trien-3-ol
  参考文献：
  名称：

  Hydrotitanation-protonation of vitamin D2 and its analogs: an efficient method for the preparation of 10,19-dihydrovitamins D2 including dihydrotachysterol2

  摘要：

  DOI：

  10.1021/jo00261a020

文献信息

• Studies on vitamin D (calciferol) and its analogs. 14. The 10,19-dihydrovitamins related to vitamin D2 including dihydrotachysterol
  作者：Antonio Mourino、William H. Okamura

  DOI：10.1021/jo00403a006

  日期：1978.4
• COTA, J. G.;MEILAN, M. C.;MOURINO, A.;CASTEDO, L., J. ORG. CHEM., 53,(1988) N6, C. 6094-6099
  作者：COTA, J. G.、MEILAN, M. C.、MOURINO, A.、CASTEDO, L.

  DOI：——

  日期：——
• Oil foamable carriers and formulations
  申请人：Foamix Pharmaceuticals Ltd.

  公开号：US20190091149A1

  公开（公告）日：2019-03-28

  A waterless foamable pharmaceutical composition suitable for external administration is disclosed. The composition includes a foamable carrier least one liquefied or compressed gas propellant. The foamable carrier includes at least one liquid oil; at least one silicone and at least one least one stabilizing agent; wherein the stabilizing agent selected from the group consisting of about 0.01% to about 25% by weight of at least one surface-active agent alone or on combination with a foam adjuvant; and about 0% to about 5% by weight of at least one polymeric agent alone or on combination with a foam adjuvant; and mixtures thereof. Pharmaceutical compositions comprising active agents, methods for their preparation, propellants suitable for use with the carriers and uses thereof are further described.