2-((E)-(2-((E)-5-bromo-2-hydroxybenzylideneamino)ethylimino)methyl)-4-bromophenol

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2-((E)-(2-((E)-5-bromo-2-hydroxybenzylideneamino)ethylimino)methyl)-4-bromophenol
• 英文别名: N,N'-bis(5'-bromosalicylidene)ethylene-1,2-diimine
• 化学式: C₁₆H₁₄Br₂N₂O₂
• 分子量: 426.107
• InChiKey: DBVLIZGESZLWBW-LQGKIZFRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.16
• 重原子数：
  22.0
• 可旋转键数：
  5.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  65.18
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  2-((E)-(2-((E)-5-bromo-2-hydroxybenzylideneamino)ethylimino)methyl)-4-bromophenol 在 甲醇 、 sodium tetrahydroborate 、 potassium hydroxide 作用下， 以 二氯甲烷 为溶剂， 生成 2-((2-(5-bromo-2-hydroxybenzylamino)ethylamino)methyl)-4-bromophenol
  参考文献：
  名称：

  一些还原的席夫碱衍生物的合成和抗菌研究

  摘要：

  在NaBH 4存在下，通过席夫碱中间体，由2-羟基苯甲醛衍生物和1,2-二胺衍生物反应制得了一系列N，N-取代的乙烯-1,2-二胺衍生物。筛选合成的化合物的抗菌活性。化合物SB01，SB02和SB09在MIC为0.40-6.25μg/ mL时显示出显着的活性。

  DOI：

  10.13005/ojc/340616
• 作为产物：
  描述：

  乙二胺 、 5-溴水杨醛 以 乙醇 为溶剂， 反应 2.0h， 以94%的产率得到2-((E)-(2-((E)-5-bromo-2-hydroxybenzylideneamino)ethylimino)methyl)-4-bromophenol
  参考文献：
  名称：

  一些还原的席夫碱衍生物的合成和抗菌研究

  摘要：

  在NaBH 4存在下，通过席夫碱中间体，由2-羟基苯甲醛衍生物和1,2-二胺衍生物反应制得了一系列N，N-取代的乙烯-1,2-二胺衍生物。筛选合成的化合物的抗菌活性。化合物SB01，SB02和SB09在MIC为0.40-6.25μg/ mL时显示出显着的活性。

  DOI：

  10.13005/ojc/340616

文献信息

• Process for the preparation of urethanes
  申请人：Jacob Andreas

  公开号：US20090275771A1

  公开（公告）日：2009-11-05

  Urethanes are prepared by oxidative carbonylation of at least one amino compound in the presence of carbon monoxide, oxygen and organic, at least one hydroxyl-group-carrying compound. The carbonylation is carried out in the absence of halogen-containing promoters. The carbonylation is also carried out in the presence of a metal complex catalyst which contains neutral bidentate N-chelate ligands of the (N˜N) type, two monoanionic N,O-chelate ligands of the general type (N˜O) − or tetradentate dianionic chelate ligands (O˜N˜N˜O) 2− .

  聚氨酯是通过氧化羰基化至少一种氨基化合物来制备的，在碳一氧化碳、氧气和有机物存在下，至少还有一种带有羟基的化合物。羰基化是在不存在含卤素的促进剂的情况下进行的。羰基化也是在含有中性双齿N-螯合配体（N˜N）类型的金属络合物催化剂存在下进行的，这种配体是两个单负离子N,O-螯合配体的一般类型(N˜O) − 或四个双负离子螯合配体（O˜N˜N˜O） 2− 。
• Design, synthesis and biological evaluation of cobalt(II)-Schiff base complexes as ATP-noncompetitive MEK1 inhibitors
  作者：Hongyue Li、Dandan Xi、Yan Niu、Chao Wang、Fengrong Xu、Lei Liang、Ping Xu

  DOI：10.1016/j.jinorgbio.2019.03.022

  日期：2019.6

  series of cobalt(II)-Schiff base complexes (CoSBC) with competent MEK1 (mitogen-activated protein kinase kinase−1) inhibitory activity. Based on our previous report, the CoSBC exhibited high binding affinity with MEK1 protein. To further explore metal complexes as MEK1 inhibitors, a series of transition metals and ligands were employed to build a library of various metal Schiff base complexes. The MEK inhibition

  在本报告中，我们设计并合成了一系列具有有效MEK1（促分裂原活化蛋白激酶激酶-1）抑制活性的钴（II）-席夫碱复合物（CoSBC）。根据我们先前的报道，CoSBC与MEK1蛋白具有很高的结合亲和力。为了进一步探索作为MEK1抑制剂的金属配合物，采用了一系列过渡金属和配体来构建各种金属席夫碱配合物的文库。MEK抑制试验表明，只有CoSBC表现出明显的抑制活性，复合物2b在BRaf（B迅速加速的纤维肉瘤）/ MEK1和MEK1 / ERK2（细胞外信号调节激酶-2）级联反应中均表现出最好的抑制作用（IC 50分别为1.988±0.14μM和1.589±0.054μM）。此外，采用均相时间分辨荧光测试方法证明了CoSBC是ATP非竞争性MEK1抑制剂。MEK激酶选择性测定表明，CoSBC可以选择性抑制MEK1 / 2激酶，而不是其他MAPK（促分裂原激活的蛋白激酶）家族激酶。此外，计算机辅助药物
• CURING ACCELERATOR FOR OXIDATION POLYMERIZED UNSATURATED RESIN, PRINTING INK, AND COATING MATERIAL
  申请人：DIC Corporation

  公开号：EP3020766A1

  公开（公告）日：2016-05-18

  There is provided a highly versatile curing accelerator for an oxidative polymerization-type unsaturated resin that is highly soluble in organic solvents, can be used outdoors, and has a curing performance equal to or higher than the curing performance of cobalt metallic soaps, which are feared to have an influence on the human body, without the use of any cobalt metallic soap. There are also provided a printing ink and a coating material that use the above curing accelerator. Specifically, the curing accelerator for an oxidative polymerization-type unsaturated resin that is used contains a fatty acid manganese salt (A) and a compound (B) represented by formula (1) below, (wherein R1 and R4 are each a hydrogen atom, a hydrocarbon group, a hydrocarbonoxy group, or an amino group, R2 and R5 are each a hydrogen atom, a hydrocarbon group, a hydrocarbonoxy group, a hydrocarbonoxycarbonyl group, a cyano group, a nitro group, or a halogen atom, R3 and R6 are each a hydrogen atom or a hydrocarbon group, and R7 is a divalent hydrocarbon group, and wherein R1 and R2 may form a ring, and and R5 may form a ring).

  本发明提供了一种用于氧化聚合型不饱和树脂的高通用性固化促进剂，它在有机溶剂中的溶解度高，可在室外使用，固化性能等同于或高于恐怕会对人体产生影响的钴金属皂的固化性能，且无需使用任何钴金属皂。此外，还提供了使用上述固化促进剂的印刷油墨和涂层材料。具体地说，所使用的氧化聚合型不饱和树脂固化促进剂含有脂肪酸锰盐 (A) 和下式 (1) 所代表的化合物 (B)、 (其中 R1 和 R4 各为氢原子、烃基、烃氧基或氨基，R2 和 R5 各为氢原子、烃基、烃氧基、烃氧羰基、氰基、硝基或卤素原子，R3 和 R6 各为氢原子或烃基，R7 为二价烃基，其中 R1 和 R2 可形成一个环，R5 可形成一个环）。
• Electronic and steric effects in manganese Schiff-base complexes as models for the water oxidation complex in photosystem II. The isolation of manganese-(<scp>II</scp>) and -(<scp>III</scp>) complexes of 3- and 3,5-substituted N,N′-bis(salicylidene)ethane-1,2-diamine (H₂salen) ligands
  作者：Manuel R. Bermejo、Alfonso Castiñeiras、Juan C. Garcia-Monteagudo、Manuel Rey、Antonio Sousa、Michael Watkinson、Charles A. McAuliffe、Robin G. Pritchard、Roy L. Beddoes

  DOI：10.1039/dt9960002935

  日期：——

  Manganese-(II) and -(III) complexes of substituted N,N'-bis(salicylidene)ethane-1,2-diamine (H(2)salen) ligands H(2)L (substituents are in the 3,5 or 3,5 positions of the phenyl rings of the salen moiety) have been prepared and thoroughly characterised. The reaction of Mn(ClO4)(2) . 6H(2)O with H(2)L in ethanol in air normally leads to manganese(III) complexes ligated by both the N2O2 ligand and water molecule(s). However, by employing electron-withdrawing substituents on the ligand, e.g. 3-Br,5-NO2, a manganese(II) complex can be obtained. A 'borderline' ligand is represented by the 5-NO2 derivative (nsalen), which produces a manganese(II) complex contaminated with a small amount of a manganese(In) species. Using a more rigorous oxidising agent in the synthesis, [Fe(eta-C5H5)(2)][FeCl4], drives the reaction totally to a manganese(III) complex [Mn(nsalen)Cl(H2O)]. In addition to magnetic susceptibility studies, cyclic voltammetry has been employed. All the complexes exhibit an oxidation and reduction peak, the reversible character being confirmed by pulse voltammetry. Pulse voltammetry also confirmed the nature of the manganese(II) species [Mn(bnsalen)(H2O)(2)]. 2H(2)O [H(2)bnsalen = N,N'-bis(3-bromo-5-nitrosalicylidene)ethane-1,2-diamine] and that a slight amount of a manganese(III) species is present in [Mn(nsalen)(H2O)(2)]. 2H(2)O. Six complexes have been crystallographically characterised. Despite the retention of an octahedral manganese environment in all of them, the supramolecular structures exhibit a wide diversity. The 3,5-dichloro and 5-bromo salen complexes containing co-ordinated water display combined pi and hydrogen bonding, as well as dimerisation. The complex [Mn(mu-dbsalen)(mu-O)}(2)] (dbsalen = 3,5-dibromo derivative) offers an alternative bridging arrangement, and [Mn(bsalen)(MeOH)(OClO3)]. H2O (bsalen = 5-bromo derivative) highlights the versatility of the manganese centre in these systems where, unexpectedly, perchlorate is co-ordinated in place of a lattice water. A more subtle rearrangement of supramolecular structure is obtained in [Mn(nsalen)Cl(H2O)] where the usual combination of pi- or hydrogen-bonding interaction is modified by the corresponding ability of the 5-NO2 substituent.
• AUTO-MAGNETIC METAL SALEN COMPLEX COMPOUND
  申请人：IHI Corporation

  公开号：EP2738157B1

  公开（公告）日：2019-07-10