sodium metaborate | 7775-19-1

• 物质功能分类: 无机化工 - 无机盐 - 硼化物、硼酸盐和过硼酸盐
• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 类金属有机物
• 英文名称: sodium metaborate
• 英文别名: sodium;oxido(oxo)borane
• CAS: 7775-19-1
• 化学式: BNaO₂
• 分子量: 65.7996
• InChiKey: NVIFVTYDZMXWGX-UHFFFAOYSA-N

物化性质

• 熔点：
  966 °C
• 沸点：
  1434 °C
• 密度：
  2.464
• 溶解度：
  溶于H2O
• 物理描述：
  Liquid
• 颜色/状态：
  White pieces or powder
• 气味：
  ODORLESS
• 稳定性/保质期：
  Stable on storage.
• 分解：
  When heated to decomposition it emits toxic vapors of boron and /sodium oxides/.
• 腐蚀性：
  NON-CORROSIVE TO FERROUS METALS

计算性质

• 辛醇/水分配系数(LogP)：
  -4.68
• 重原子数：
  4
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  40.1
• 氢给体数：
  0
• 氢受体数：
  2

ADMET

代谢

硼酸、硼酸钠和硼酸盐不会被代谢，也不会在体内积累，除了在骨骼中有少量沉积。没有报告称有机硼化合物作为代谢产物。

Boric acid, sodium salt and borates are not metabolized, neither do they accumulate in the body except for low deposit in bone. No organic boron compounds have been reported as metabolites.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

A4；无机硼化合物/不可分类为人类致癌物。

A4; Not classifiable as a human carcinogen. /Borate compounds, Inorganic/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 副作用

职业性肝毒素 - 第二性肝毒素：在职业环境中的毒性效应潜力是基于人类摄入或动物实验的中毒案例。 肾毒素 - 该化学品在职业环境中可能对肾脏有毒。 生殖毒素 - 对生殖系统有毒的化学品，包括后代缺陷以及损害男性或女性生殖功能。生殖毒性包括发育效应。参见生殖毒性风险评估指南。

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation. Nephrotoxin - The chemical is potentially toxic to the kidneys in the occupational setting. Reproductive Toxin - A chemical that is toxic to the reproductive system, including defects in the progeny and injury to male or female reproductive function. Reproductive toxicity includes developmental effects. See Guidelines for Reproductive Toxicity Risk Assessment.

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 解毒与急救

保持呼吸道通畅，必要时协助通气。如果出现昏迷、癫痫、低血压和肾衰竭，则进行治疗。没有特定的解毒剂。给予活性炭（尽管硼酸吸收不佳）。对于大量摄入，考虑洗胃。/硼酸、硼酸盐和硼/

Maintain an open airway and assist ventilation if nescessary. treat coma, seizures, hypotension, and renal failure if they occur. There is no specific antidote. Administer activated charcoal (although boric acid is not well absorbed). Consider gastric lavage for large ingestions. /Boric acid, Borates, and Boron/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

血液透析是有效的，并且在大剂量摄入后以及作为肾衰竭支持性治疗时被推荐。腹膜透析在提高婴儿排泄方面并未证明有效。/硼酸、硼酸盐和硼/

Hemodialysis is effective and is indicated after massive ingestions and for supportive care of renal failure. Peritoneal dialysishas not proved effective in enhancing elimination in infants. /Boric acid, Borates, and Boron/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

在急性中毒情况下，如果摄入了大量毒物，并且患者在接触后一小时内被看到，应考虑进行胃肠道去污染... 需要牢记的是，呕吐和腹泻很常见，严重中毒可能与癫痫发作有关。因此，在这些接触情况下，使用吐根糖浆诱导呕吐可能是禁忌的。如果存在腹泻，则不宜使用泻药。/硼酸和硼酸盐/

In acute poisonings, if a large amount has been ingested and the patient is seen within one hour of exposure, gastrointestinal decontamination should be considered ... .It is important to keep in mind that vomiting and diarrhea are common, and severe poisoning may be associated with seizures. Therefore induction of emesis by syrup of ipecac is probably contraindicated in these exposures. Catharsis is not indicated if diarrhea is present. /Boric acid and Borates/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

排泄主要通过尿液进行。肾脏由于在排泄过程中达到最高浓度而受到更严重的损害。

Excretion occurs primarily in the urine. The kidneys are more seriously damaged because of highest concentration reached during excretion.

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 海关编码：
  2840200000

SDS

Name:	Sodium metaborate tetrahydrate p.a. Material Safety Data Sheet
Synonym:	None
CAS:	7775-19-1

Section 1 - Chemical Product MSDS Name:Sodium metaborate tetrahydrate p.a. Material Safety Data Sheet
Synonym:None

---

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
7775-19-1	Sodium metaborate tetrahydrate	100	unlisted

Hazard Symbols: None Listed.
Risk Phrases: None Listed.

---

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation.
Chronic:
No information found.

---

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear.
Notes to Physician:

---

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

---

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.

---

Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Use with adequate ventilation.
Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid breathing dust.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

---

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 7775-19-1: CAS# 10555-76-7: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

---

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Powder
Color: white granular
Odor: Not available.
pH: alkaline in water
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 57 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: N/A
Explosion Limits, upper: N/A
Decomposition Temperature:
Solubility in water: soluble
Specific Gravity/Density:
Molecular Formula: BNaO2.4H2O
Molecular Weight: 137.86

---

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Dust generation.
Incompatibilities with Other Materials:
No significant incompatibilities identified with common materials and contaminants..
Hazardous Decomposition Products:
No data available.
Hazardous Polymerization: Has not been reported.

---

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 7775-19-1: ED4640000 CAS# 10555-76-7 unlisted.
LD50/LC50:
CAS# 7775-19-1: Oral, rat: LD50 = 2330 mg/kg.
CAS# 10555-76-7.
Carcinogenicity:
Sodium metaborate anhydrous - Not listed by ACGIH, IARC, or NTP.
Sodium metaborate tetrahydrate - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

---

Section 12 - ECOLOGICAL INFORMATION
Other No information available.

---

Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

---

Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
IMO
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
RID/ADR
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing group:

---

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 7775-19-1: 1
CAS# 10555-76-7: No information available.
Canada
CAS# 7775-19-1 is listed on Canada's DSL List.
CAS# 7775-19-1 is not listed on Canada's Ingredient Disclosure List.
CAS# 10555-76-7 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 7775-19-1 is listed on the TSCA inventory.
CAS# 10555-76-7 is not on the TSCA Inventory because it is a hydrate.
It is considered to be listed if the CAS number for the anhydrous form
is on the inventory (40CFR720.3(u)(2)).

---

SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

理化性质

偏硼酸钠是制造硼砂的中间产物，化学式为NaBO₂，分子量65.80。其晶体结构为无色六方系棱柱形，熔点966℃，沸点1434℃，相对密度2.464。该物质易溶于水和甘油，难溶于乙醇，并不溶于酸。偏硼酸钠的水溶液呈现强碱性。

偏硼酸钠四水合物为无色或白色晶体，熔点57℃，易溶于水，其溶液同样呈强碱性，但不溶于乙醇。当受热至120℃时，即会失去一分子结晶水。

制备方法

偏硼酸钠可通过将煅烧粉碎后的硼镁矿石用30%的烧碱溶液加热分解后，经过滤、浓缩、冷却和结晶等步骤制得。

用途

偏硼酸钠可用于分析试剂及除锈剂和洗涤剂。此外，它还可用作防腐剂。

反应信息

• 作为反应物：
  描述：

  sodium metaborate 在 双氧水 作用下， 生成 sodium perborate
  参考文献：
  名称：

  Le Blanc; Zellmann, Zeitschrift fur Elektrochemie, 1923, vol. 29, p. 184

  摘要：

  DOI：
• 作为产物：
  描述：

  sodium hydroxide 生成 sodium metaborate
  参考文献：
  名称：

  KARAZHANOV N. A.; FILIPPOVA Z. O.; MAKATOVA I. N.; SARSENOV S. K., KOMPLEKS. ISPOLZ. MINERAL. SYRYA,(1987) N 1, 72-75

  摘要：

  DOI：
• 作为试剂：
  描述：

  1-azido-3-methylbutan-2-one 在 sodium metaborate 、 双氧水 、 三苯基膦 、 三氯氧磷 作用下， 以 溶剂黄146 、 苯 为溶剂， 反应 38.0h， 生成 吡嗪,3-氯-2,5-二(2-甲基丙基)-
  参考文献：
  名称：

  来自鳄鱼粘杆菌和海洋细菌的新型吡嗪

  摘要：

  使用 CLSA 或 SPME 顶空方法收集了来自北海的 2 株粘杆菌 Chondromyces crocatus 和 7 株海洋 Alphaproteobacteria 释放的挥发物，并通过 GC-MS 进行分析。在 C. crocatus 的提取物中鉴定出属于不同类别的 27 种吡嗪。2,5-二烷基吡嗪和相关的3-甲氧基-2,5-二烷基吡嗪占主导地位。从天然来源获得了几种吡嗪，如 2-(1-甲基乙烯基)-5-(1-甲基乙基)吡嗪 (7) 和具有甲基、异丙基、异丁基或仲丁基侧链的 3-甲氧基-2,5-二烷基吡嗪首次。鉴定必须依赖合成参考材料，这些参考材料是使用 Furstner 铁催化的氯吡嗪与格氏试剂偶联或叠氮酮缩合获得的关键步骤。合成材料允许鉴定两种以前未知的细菌来源的菠萝甲虫 Carpophilus humeralis 引诱剂，即 3-甲氧基-2-(1-甲基丙基)-5-(2-甲基丙基)吡嗪

  DOI：

  10.1002/ejoc.200500280

文献信息

• 1-acylpiperidine compounds
  申请人：Ciba-Geigy Corp.

  公开号：US05310743A1

  公开（公告）日：1994-05-10

  1-Acylpiperidine compound of the formula I ##STR1## in which R.sub.1 is an optionally substituted aralkyl, aryloxyalkyl, heteroaralkyl, aroyl, heteroaroyl, cycloalkylcarbonyl, aralkanoyl, heteroarylalkanoyl, aralkoxycarbonyl or arylcarbamoyl radical or the acyl radical of an .alpha.-amino acid which is optionally N-substituted by lower alkanoyl or carbamoyl-lower-alkanoyl, R.sub.2 is cycloalkyl or an optionally substituted aryl or heteroaryl radical, R.sub.3 is hydrogen, alkyl, carbamoyl or an alkanoyl or alkenoyl radical which is optionally substituted by carboxyl or esterified or amidated carboxyl, R.sub.4 is an optionally substituted aryl or optionally partially hydrogenated heteroaryl radical, X.sub.1 is methylene, ethylene, a direct linkage, an optionally ketalised carbonyl group or an optionally etherified hydroxymethylene group, X.sub.2 is alkylene, carbonyl or a direct linkage, and X.sub.3 is carbonyl, oxo-lower-alkylene, oxo(aza)-lower-alkylene or an alkylene radical which is optionally substituted by phenyl, hydroxymethyl, optionally esterified or amidated carboxyl or, in higher than the .alpha. position, by hydroxyl, and its salts have substance-P-antagonistic properties and can be used as pharmaceutically active substances in pharmaceuticals for the treatment of disorders in whose development substance P plays an essential part.

  公式I的1-酰基哌啶化合物##STR1##中，其中R.sub.1是可选择地取代的芳基烷基，芳氧基烷基，杂芳基烷基，芳酰基，杂芳酰基，环烷基羰基，芳基酰基，杂芳基酰基，芳基羧酰基或芳基氨基酸的酰基基团，该基团可选择地通过较低的烷酰基或氨基甲酰基取代，R.sub.2是环烷基或可选择地取代的芳基或杂芳基基团，R.sub.3是氢，烷基，氨基甲酰基或可选择地通过羧基取代或酯化或酰胺化羧基的烷酰基或烯酰基基团，R.sub.4是可选择地取代的芳基或可选择部分氢化的杂芳基基团，X.sub.1是亚甲基，乙烯基，直链键，可选择地缩酮化的羰基团或可选择地醚化的羟甲亚甲基团，X.sub.2是烷基，羰基或直链键，X.sub.3是羰基，氧代-较低烷基，氧代（氮代）-较低烷基或可选择地通过苯基，羟甲基，可选择地酯化或酰胺化羧基或在高于α位时通过羟基取代的烷基基团，及其盐具有物质P拮抗性能，并可用作药用活性物质，用于治疗发展中物质P起重要作用的疾病的药物。
• .delta.-amino-.gamma.-hydroxy-.omega.-aryl-alkanoic acid amides
  申请人：Ciba-Geigy Corporation

  公开号：US05559111A1

  公开（公告）日：1996-09-24

  .delta.-Amino-.gamma.-hydroxy-.omega.-aryl-alkanoic acid amides of formula I ##STR1## and the salts thereof, have renin-inhibiting properties and can be used as antihypertensive medicinal active ingredients.

  公式I的.delta.-氨基-.gamma.-羟基-.ω-芳基-烷基酸酰胺及其盐具有抑制肾素的性质，可用作降压药物活性成分。
• Cyclic imines as pesticides
  申请人：Bayer Aktiengesellschaft

  公开号：US06274613B1

  公开（公告）日：2001-08-14

  The invention relates to novel cyclic imines of the formula (I) in which Ar1 and Ar2 each represent substituted phenyl and n represents 1, to a process for their preparation and to their use as pesticides.

  本发明涉及式(I)的新环状亚胺 其中Ar1和Ar2各自代表取代的苯基，n代表1，本发明还涉及它们的制备方法及其作为农药的使用。
• Fungicidal and plant-growth regulating azolyl ether ketones and alcohols
  申请人：Bayer Aktiengesellschaft

  公开号：US04878939A1

  公开（公告）日：1989-11-07

  Azolyl ether ketones and alcohols of the formula ##STR1## in which R.sup.1 and R.sup.2 each independently represents alkyl with more than one carbon atom, or R.sup.1 represents dichloromethyl, trichloromethyl, chlorovinyl or dichlorovinyl, and R.sup.2 represents alkyl, R.sup.3 represents alkyl, A represents the keto group or a CH(OH) grouping, Z represents a nitrogen atom or the CH group, X represents oxygen or sulphur and Ar represents optionally substituted phenyl, or addition products thereof with acids and metal salts, are active against fungi and in regulating the growth of plants. New intermediates therefor are also shown.

  Azolyl醚酮和醇的化学式为##STR1##，其中R.sup.1和R.sup.2分别独立表示具有多于一个碳原子的烷基，或者R.sup.1表示二氯甲基、三氯甲基、氯乙烯基或二氯乙烯基，而R.sup.2表示烷基，R.sup.3表示烷基，A表示酮基或CH(OH)基团，Z表示氮原子或CH基团，X表示氧或硫，Ar表示可选择取代的苯基，或其与酸和金属盐的加合物，对真菌具有活性并且能够调节植物生长。同时还展示了用于制备这些化合物的新中间体。
• Fungicidal phenoxytriazolyl ketones and carbinols
  申请人：Bayer Aktiengesellschaft

  公开号：US04610996A1

  公开（公告）日：1986-09-09

  Phenoxytriazolyl ketones and carbinols of the formula ##STR1## in which A represents the keto group or the CH(OH) grouping and R represents hydrogen, alkenyl, alkinyl, halogenoalkyl, halogenoalkenyl, alkylcarbonyl, optionally substituted benzyl or optionally substituted phenoxymethyl, or addition products thereof with acids or metal salts, which possess fungicidal activity.

  Phenoxytriazolyl酮和公式中的羟基醛##STR1##，其中A代表酮基或CH(OH)基团，R代表氢、烯基、炔基、卤代烷基、卤代烯基、烷基甲酰、可选择取代的苄基或可选择取代的苯氧甲基，或其与酸或金属盐的加合物，具有杀真菌活性。

表征谱图