亚砷酸钠 | 7784-46-5

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 类金属有机物
• 中文名称: 亚砷酸钠
• 中文别名: 二氧砷酸钠
• 英文名称: sodium arsenite
• 英文别名: sodium metaarsenite；NaAsO2；Atlas "A"；sodium;oxoarsinite
• CAS: 7784-46-5
• 化学式: AsO₂*Na
• 分子量: 129.91
• InChiKey: PTLRDCMBXHILCL-UHFFFAOYSA-M

物化性质

• 稳定性/保质期：

  1. 稳定性[12]

     • 稳定

  2. 禁配物[13]

     • 强氧化剂、强酸、二氧化碳

  3. 避免接触的条件[14]

     • 空气、受热

  4. 聚合危害[15]

     • 不聚合

  5. 分解产物[16]

     • 氧化砷、氧化钠

计算性质

• 辛醇/水分配系数(LogP)：
  -4.68
• 重原子数：
  4
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  40.1
• 氢给体数：
  0
• 氢受体数：
  2

ADMET

代谢

这项研究调查了家兔在摄入亚砷酸钠和水溶性二巯基化合物后尿液中亚砷酸钠的代谢物。给家兔皮下注射NaAsO2（按体重1毫克/千克砷）一小时后，分别肌肉注射生理盐水、2,3-二巯基-1-丙磺酸、间-二巯基丁二酸或N-(2,3-二巯基丙基)酞酰亚胺酸，剂量为0.2毫摩尔/千克。通过组合阴离子-阳离子交换色谱法从处理过的家兔尿液中分离亚砷酸钠代谢物。柱层析馏分经酸消化后，通过直接氢化物火焰原子吸收光谱法分析砷含量。在只给予亚砷酸钠的家兔0到24小时尿液中发现的无机砷、甲基砷酸盐和二甲砷酸盐的相对量与口服亚砷酸钠的人体报告非常接近。这一发现表明家兔对亚砷酸钠的生物转化方式与人类非常相似。在给予二巯基化合物后，0到24小时内尿液中总砷的排泄量有所提高，但在0到48小时内的总砷排泄量不受影响。这一结果表明这些二巯基化合物的作用发生在治疗后的早期。此外，这些二巯基化合物对0到24小时内尿液中砷代谢物排泄量的影响各不相同。2,3-二巯基-1-丙磺酸、间-二巯基丁二酸或2,3-二巯基-1-丙磺酸增加了砷酸盐的排泄但减少了二甲砷酸盐的排泄。2,3-二巯基-1-丙磺酸或N-(2,3-二巯基丙基)酞酰亚胺酸处理增加了甲基砷酸盐的排泄，但间-二巯基丁二酸没有影响。在2,3-二巯基-1-丙磺酸或间-二巯基丁二酸治疗后，砷酸盐的排泄增加，但N-(2,3-二巯基丙基)酞酰亚胺酸处理没有影响。这些结果提示，除了增加砷的排泄外，这些二巯基化合物还影响亚砷酸钠向毒性较小的物种的生物转化。对尿液中砷代谢物排泄的不同影响表明，这些二巯基金属结合剂的作用机制不仅仅是简单螯合无机砷。

The urinary metabolites of sodium arsenite have been investigated in rabbits given sodium arsenite and water-soluble dimercaptans. Rabbits injected sc with NaAsO2 (1 mg arsenic/kg) were given im 1 hr later, either saline, 2,3-dimercapto-1-propanesulfonic acid, mesodimercaptosuccinic acid, or N-(2,3-dimercaptopropyl)phthalamidic acid at 0.2 mmol/kg. Arsenic metabolites in urine collected from treated rabbits were isolated by combined anion-cation-exchange chromatography. Column fractions were acid-digested and analyzed for arsenic by direct hydride-flame atomic absorption spectrophotometry. The relative amounts of inorganic arsenic, methylarsonate, and dimethylarsinate found in 0 to 24 hr urine of rabbits given only sodium arsenite agreed closely with those reported for human subjects given arsenite po. This finding suggests that the rabbit biotransforms arsenite in a manner very similar to humans. The urinary excretion of total arsenic between 0 and 24 hr was elevated after dimercaptan administration. but urinary excretion of total arsenic between 0 and 48 hr was unaffected. This result indicates that the action of these dimercaptans occurs early after treatment. In addition, the dimercaptans influenced differently the amounts of the arsenic metabolites excreted in the urine between 0 and 24 hr. 2,3-Dimercapto-1-propanesulfonic acid, mesodimercaptosuccinic acid, or 2,3-dimercapto-1-propanesulfonic acid increased arsenite excretion but decreased dimethylarsinate excretion. 2,3-dimercapto-1-propanesulfonic acid or N-(2,3-dimercaptopropyl)phthalamidic acid treatment increased methylarsonate excretion but mesodimercaptosuccinic acid did not. Arsenate excretion increased after 2,3-dimercapto-1-propanesulfonic acid or mesodimercaptosuccinic acid, treatment but was not affected by N-(2,3-dimercaptopropyl)phthalamidic acid treatment. These results suggest that the dimercaptans, in addition to increasing arsenic excretion, also influence the biotransformation of arsenite to less toxic species. The different effects on the urinary excretion of arsenic metabolites suggest that these dimercaptan metal binding agents have mechanisms of action in addition to simple chelation of inorganic arsenic.

来源:Hazardous Substances Data Bank (HSDB)

代谢

真菌 Candida hemicola 将亚砷酸钠生物转化为三甲基胂烷。

The fungi Candida hemicola biotransforms sodium arsenite to trimethyl arsine.

来源:Hazardous Substances Data Bank (HSDB)

代谢

牛和狗每天被喂食亚砷酸钠和砷酸钠，连续五天。收集尿液并分析甲基砷酸和 无机砷酸。在牛体内，甲基砷酸和无机砷酸的水平分别上升至0.1至0.5 ppm和1.0至4.0 ppm。当牛恢复正常饮食后，所有值均恢复到对照水平（0.02至0.10 ppm和0.1至0.2 ppm）。在狗体内，喂食亚砷酸钠产生了相同的峰值，甲基砷酸和无机砷酸均为5.0至7.0 ppm。给狗喂食砷酸钠后，甲基砷酸的水平上升至10 ppm，无机砷酸上升至5.0 ppm。在停止食用含砷食物六天后，所有值均恢复到对照水平……。

Cows and dogs were fed sodium arsenite and sodium arsenate daily for five days. Urine was collected and analyzed for methylarsenate and inorganic arsenate. In the cow, the levels rose to 0.1 to 0.5 and 1.0 to 4.0 ppm, respectively. When cows were returned to normal diets, all values returned to control levels (0.02 to 0.10 ppm and 0.1 to 0.2 ppm). In dogs, arsenite feeding produced identical peak values 5.0 to 7.0 ppm for both methylarsenate and inorganic arsenate. Feeding of sodium arsenate to dogs produced a rise to 10 ppm methylarsenate and 5.0 ppm inorganic arsenate. Six days after withdrawal from the arsenic-containing diet, all values reached control levels ... .

来源:Hazardous Substances Data Bank (HSDB)

代谢

小鼠在暴露于有毒浓度的亚砷酸钠（250 mg As(III)/l）2、6和8天后，通过肌肉注射给药1.3 mg As(III)/kg。未暴露于处理过的饮用水的小鼠排出了肌肉注射给药的一半的As(III)，而之前暴露于处理过的水的小鼠在2天内排出了80%的As(III)作为As(V)；4天后排出了超过95%；8天后只检测到少量的As(III)存在……。

Mice were administered im 1.3 mg As(III)/kg after exposure to a toxic concentration of sodium arsenite (250 mg As(III)/l) for 2, 6 and 8 days. Whereas mice not exposed to the treated drinking water excreted one-half the im administered As(III), those mice previously exposed to the treated water excreted 80% of the applied As(III) as As(V) in 2 days; more than 95%, after 4 days; and after 8 days only traces of As(III) were present ... .

来源:Hazardous Substances Data Bank (HSDB)

代谢

培养的BALB/3T3-Cl-A31-1-1小鼠胚胎细胞被用于研究三价砷（以亚砷酸钠形式存在，即砷(3+)）和五价砷（以砷酸钠形式存在，即砷(5+)）的细胞毒性、致癌转化以及代谢还原或氧化。细胞对砷(3+)和砷(5+)的摄取在第一个小时内最高，并且与剂量有关；用等摩尔浓度的试剂处理的细胞显示砷(3+)的摄取量是砷(5+)的四倍。尽管两种产物在细胞内总砷含量方面没有差异，但砷(3+)比砷(5+)更具细胞毒性。砷(3+)相对于砷(5+)的相对转化活性大约为4:1。砷(5+)在细胞内显示出高代谢还原率；砷(5+)暴露导致细胞质中超过70%的砷(3+)，而砷(3+)暴露则达到100%。离子交换色谱没有检测到任何甲基化代谢物。在无细胞培养基孵化中，多达30%的砷(3+)被氧化为砷(5+)，而在细胞存在的情况下，只有4%的氧化。未变化的砷(5+)在无细胞培养基孵化后回收，而细胞的存在以剂量依赖性方式导致产生多达5%的砷(3+)。用二乙基马来酸酯耗尽谷胱甘肽可以抑制细胞将砷(5+)还原为砷(3+)，抑制率高达25%。作者得出结论，砷(3+)是无机砷的细胞毒性和转化作用的负责物质。

Cultured BALB/3T3-Cl-A31-1-1 mouse embryo cells were used to study the cytotoxicity, neoplastic transformation, and metabolic reduction or oxidation of trivalent arsenic, in the form of sodium arsenite (arsenic(3+)), and pentavalent arsenic, in the form of sodium arsenate (arsenic(5+)). Uptake of arsenic(3+) and arsenic(5+) by the cells was highest during the first hour and was dose dependent; cells treated with equimolar concn of the agents demonstrated four fold greater uptake for arsenic(3+) than for arsenic(5+). Arsenic(3+) was more cytotoxic than arsenic(5+), although no differences were apparent between the two products with respect to total arsenic in the cells. The relative transformation activity for arsenic(3+) compared to arsenic(5+) was equal to about 4:1. Arsenic(5+) showed a high rate of intracellular metabolic reduction; arsenic(5+) exposure yielded more than 70 percent arsenic(3+) in cytosol, as compared to 100 percent for arsenic(3+) exposure. Ion exchange chromatography did not detect any methylated metabolites. In cell free medium incubations, up to 30 percent of arsenic(3+) was oxidized to arsenic(5+), as compared to only 4 percent oxidation in the presence of cells. Unchanged arsenic(5+) was recovered following its incubation in cell free medium, while the presence of cells resulted in the generation of up to 5 percent arsenic(3+), in a dose dependent manner. The reduction of arsenic(5+) to arsenic(3+) by the cells was inhibited up to 25 percent by depletion of glutathione with diethylmaleate. The authors conclude that arsenic(3+) is responsible for the cytotoxic and transforming action of inorganic arsenic.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 毒性总结

砒霜及其代谢物通过多种机制干扰ATP的产生。在柠檬酸循环层面，砒霜抑制了丙酮酸脱氢酶，并通过与磷酸竞争解耦了氧化磷酸化，从而抑制了与能量相关的NAD+还原、线粒体呼吸和ATP合成。过氧化氢的产生也增加了，这可能会形成活性氧物种和氧化应激。砒霜的致癌性受到砒霜与微管蛋白结合的影响，导致非整倍体、多倍体和有丝分裂停滞。其他砒霜蛋白靶点的结合也可能导致DNA修复酶活性改变、DNA甲基化模式改变和细胞增殖。

Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. Arsenic's carginogenicity is influenced by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. The binding of other arsenic protein targets may also cause altered DNA repair enzyme activity, altered DNA methylation patterns and cell proliferation. (T1, A17)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 致癌性证据

致癌性分类：1）人类证据：充分；2）动物证据：有限。对人类致癌风险的总体评估为第1组：对人类致癌。注意：此评估适用于整个化学物质组，而不一定适用于组内所有单个化学物质。/砷和砷化合物/

Classification of carcinogenicity: 1) evidence in humans: sufficient; 2) evidence in animals: limited. Overall summary evaluation of carcinogenic risk to humans is Group 1: Carcinogenic to humans. NOTE: This evaluation applies to the group of chemicals as a whole and not necessarily to all individual chemicals within the group. /Arsenic and arsenic compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

分类：A；人类致癌物。分类依据：基于足够的人类数据。在主要通过吸入暴露的多个人类群体中观察到了肺癌死亡率的增加。此外，在饮用富含无机砷的水的人群中，观察到了多个内部器官癌症（肝脏、肾脏、肺和膀胱）死亡率的增加以及皮肤癌发病率的增加。人类致癌性数据：充分。动物致癌性数据：不足。/无机砷/ /基于先前的分类系统/

CLASSIFICATION: A; human carcinogen. BASIS FOR CLASSIFICATION: Based on sufficient evidence from human data. An increased lung cancer mortality was observed in multiple human populations exposed primarily through inhalation. Also, increased mortality from multiple internal organ cancers (liver, kidney, lung, and bladder) and an increased incidence of skin cancer were observed in populations consuming drinking water high in inorganic arsenic. HUMAN CARCINOGENICITY DATA: Sufficient. ANIMAL CARCINOGENICITY DATA: Inadequate. /Inorganic Arsenic/ /Based on former classification system/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

A1：确认的人类致癌物。/砷和无机砷化合物，如As/

A1: Confirmed human carcinogen. /Arsenic and inorganic compounds, as As/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

评估：有足够的人类证据表明饮用水中的砷可导致膀胱癌、肺癌和皮肤癌...总体评估：饮用水中的砷对人类具有致癌性（第1组）。/饮用水中的砷/

Evaluation: There is sufficient evidence in humans that arsenic in drinking-water causes cancers of the urinary bladder, lung and skin ... Overall evaluation: Arsenic in drinking-water is carcinogenic to humans (Group 1). /Arsenic in drinking-water/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

砷酸盐穿过胎盘。

Arsenite crosses the placenta.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

无机砷化合物从消化道的吸收速率取决于它们的溶解性。亚砷酸钠易溶，因此能够迅速被吸收。

RATE OF ABSORPTION OF INORG ARSENICALS FROM DIGESTIVE TRACT DEPENDS UPON THEIR SOLUBILITY. SODIUM ARSENITE IS READILY SOL, RAPIDLY ABSORBED.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

在给一名晚期癌症患者静脉注射4毫克含有76号砷的亚砷酸钠后20小时，砷含量最高的部位是肝脏和肾脏，而其他各种组织的砷含量相对较低。在给两名晚期癌症患者静脉注射标记的亚砷酸钠后24小时内，76号砷的排泄量为注射剂量的16.7%；主要通过尿液排泄。

AT 20 HR AFTER IV INJECTION OF 4 MG (76)ARSENIC AS SODIUM ARSENITE TO ONE PATIENT WITH TERMINAL CANCER, HIGHEST LEVELS OF ARSENIC WERE FOUND IN LIVER & KIDNEYS & RELATIVELY SMALLER LEVELS IN VARIOUS OTHER TISSUES. EXCRETION OF (76)ARSENIC IN THE FIRST 24 HOURS AFTER AN IV INJECTION OF LABELLED SODIUM ARSENITE TO 2 PATIENTS WITH TERMINAL CANCER WAS 16.7% OF THE INJECTED DOSE; EXCRETION WAS MAINLY VIA THE URINE.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

在给五只大鼠和四只家兔静脉注射(76)砒霜（亚砷酸钠）后，前48小时内尿液中(76)砒霜的排泄量在大鼠中少于剂量的10%，在家兔中为30%。在小鼠中，在首次24小时内，剂量的75%被排出。在所有测试的物种中，少于10%的总剂量通过粪便排出。与家兔不同，大鼠会在血液中长时间保留大部分注射的剂量。组织分布研究显示，在大鼠血液和脾脏中(76)砒霜的水平最高，在家兔的肝脏、肾脏和肺中，以及在小鼠的肝脏、肾脏和脾脏中。

FOLLOWING IV ADMINISTRATION OF (76)ARSENIC AS SODIUM ARSENITE TO FIVE RATS AND FOUR RABBITS, THE URINARY EXCRETION OF (76)ARSENIC IN THE FIRST 48 HOURS WAS LESS THAN 10% OF THE DOSE IN RATS AND 30% IN RABBITS. FOLLOWING IP INJECTION IN MICE, 75% OF THE DOSE WAS EXCRETED WITHIN THE FIRST 24 HOURS. IN ALL SPECIES TESTED, LESS THAN 10% OF THE TOTAL ... WAS EXCRETED IN THE FECES. UNLIKE RABBITS, RATS RETAIN MOST OF THE INJECTED DOSE IN THE BLOOD FOR A PROLONGED PERIOD. TISSUE DISTRIBUTION STUDIES REVEALED HIGHEST LEVELS OF (76)ARSENIC IN THE BLOOD AND SPLEEN OF RATS, IN THE LIVER, KIDNEYS AND LUNGS OF RABBITS AND IN THE LIVER, KIDNEYS AND SPLEEN OF MICE.

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 储存条件：
  储存注意事项：应将物品存放在阴凉、通风良好的专用库房内，并实行“双人收发、双人保管”制度。远离火种和热源，确保包装密封。与氧化剂、酸类及食用化学品分开存放，严禁混储。存储区域应配备适当的材料以处理泄漏情况。

制备方法与用途

制备方法

在快速搅拌下，将100g亚砷酸酐分次加入到250ml密度为0.91的氢氧化铵溶液中，加热反应。静置至沉淀完全后，在搅拌下缓慢加入约38%的氢氧化钠溶液直至沉淀溶解。随后滤去不溶物，滤液在真空条件下蒸发浓缩（约80℃）至浆状，并进行吸水干燥结晶。使用少量乙醇洗涤至合格后，干燥即得试剂亚砷酸钠。

合成制备方法

同样地，在快速搅拌下，将100g亚砷酸酐分次加入到250ml密度为0.91的氢氧化铵溶液中，并加热反应。静置直至沉淀完全，在搅拌下缓慢滴加约38%的氢氧化钠溶液至沉淀溶解。滤去不溶物后，滤液在真空条件下浓缩（约80℃）至浆状并干燥结晶，再用少量乙醇洗涤合格，最后干燥即得试剂亚砷酸钠。

用途简介

亚砷酸钠主要用于杀虫剂、防腐剂以及分析试剂等。

用途

亚砷酸钠广泛用于杀虫剂、防腐剂和分析试剂等领域。[18]

反应信息

• 作为反应物：
  描述：

  亚砷酸钠 在 2,2,6,6-四甲基哌啶氧化物 作用下， 反应 1.0h， 生成 砷酸、原砷酸
  参考文献：
  名称：

  使用芽孢杆菌孢子–2,2,6,6-四甲基哌啶-1-氧基系统将As（III）快速催化氧化为As（V）

  摘要：

  As（III）氧化为As（V）是处理污水的关键过程。我们发现，漆酶–2,2,6,6-四甲基哌啶-1-氧基（TEMPO）系统在1小时内可以将95％的As（III）（10 mg L -1）快速氧化为As（V）。基于这一发现，我们用枯草芽孢杆菌的孢子代替漆酶进行As（III）氧化，因为前者表面上有大量的CotA-漆酶。表达CotA蛋白并敲除cotA证实了CotA蛋白和孢子的催化能力。来自野生型孢子的基因。漆酶-和孢子-TEMPO系统均显示相似的氧化速率常数，Michaelis-Menten常数和最大速度，这是由于在溶解氧存在下TEMPO的氧铵阳离子的形成。其他几种漆酶介体，例如2,2'-叠氮基双（3-乙基苯并噻唑啉-6-磺酸）（ABTS），乙酰丁香酮（AS），1-羟基苯并三唑（HBT），丙烯酸2-羟基丁酯（HBA），紫罗兰还详细研究了酸（VLA），4-氧-TEMPO，4-氨基-TEMPO，4-甲

  DOI：

  10.1039/c8gc03654c
• 作为产物：
  描述：

  Disodium;hydron;arsorate 生成 亚砷酸钠
  参考文献：
  名称：

  Zeitschrift fur anorganische Chemie 1933, 212, 289-304

  摘要：

  DOI：
• 作为试剂：
  描述：

  sodium tetrathiocarbonate 在 亚砷酸钠 作用下， 以 not given 为溶剂， 生成 sodium trithiocarbonate
  参考文献：
  名称：

  Danilov, S.; Grad, N. M.; Vorob'eva, A. F., Zhurnal Obshchei Khimii, 1949, vol. 19, p. 1257 - 1289

  摘要：

  DOI：

文献信息

• A new 3D POMOF with two channels consisting of Wells–Dawson arsenotungstate and {Cl₄Cu₁₀(pz)₁₁} complexes: synthesis, crystal structure, and properties
  作者：Bo-Wen Cong、Zhan-Hua Su、Zhi-Feng Zhao、Wen-Qi Zhao、Xiu-Juan Ma、Qiu Xu、Li-Juan Du

  DOI：10.1039/c7nj04854h

  日期：——

  and Cl4Cu10(pz)11} complexes. Compound 1 possesses two different channels which form a 3D topology framework with the Schläfli symbol of 3·4·56·67}23·46·53}232·42·56·65}. Additionally, compound 1 shows photoluminescence properties and excellent photocatalytic activity for the degradation of RhB dye under UV irradiation. The photocatalytic reaction kinetics and mechanism have been also investigated

  在此，使用水热反应合成了新的3D POMOF [Cl 4 Cu 10（pz）11 } As 2 W 18 O 62 }]·1.5H 2 O（pz =吡嗪）（1）。单晶X射线衍射分析，元素分析，IR，TG和UV-vis-NIR光谱，XPS，BET分析和XRD。单晶X射线分析表明，化合物1由经典的Wells-Dawson [As 2 W 18 O 62 ] 6-聚氧阴离子和Cl 4 Cu 10（pz）11}复合体。化合物1具有两个不同的通道，这些通道形成带有Schläfli符号3·4·5 6 ·6 7 } 2 3·4 6 ·5 3 } 2 3 2 ·4 2 ·5 6 ·6的3D拓扑框架。5 }。另外，化合物1对于在紫外线照射下降解RhB染料显示出光致发光性质和优异的光催化活性。还研究了光催化反应动力学和机理。
• Assembly of six [H_xAs₂Mo₆O₂₆]^(6−x)− cluster-based hybrid materials from 1D chains to 3D framework with multiple Cu–N complexes
  作者：Bo-Wen Cong、Zhan-Hua Su、Zhi-Feng Zhao、Bao-Yi Yu、Wen-Qi Zhao、Lin Xia、Xiu-Juan Ma、Bai-Bin Zhou

  DOI：10.1039/c7ce00319f

  日期：——

  4′-bipy)1.5(H2O)2}2H2As2Mo6O26}] (1), [Cu (biim)2}2HAs2Mo6O26}Cu(biim)Cl}]·H2O (2), (H2bib)[Cu(H2O)2(bib)}H2As2Mo6O26}]·2H2O (3), [(Hbix)Cu(bix)0.5}2As2Mo6O26}]·2H2O (4), [Cu(bmb)1.5(H2O)}2H2As2Mo6O26}]·2H2O (5), 0 and [Cu2(bth)4}H2As2Mo6O26}]·H2O (6) (4,4′-bipy = 4,4′-bipyridine; biim = biimidazole; bib = 1,4-bis(1-imidazolyl)benzene; bix = 1,4-bis(imidazol-1-ylmethyl)benzene; bmb = 1,4-bis(be

  一系列有机-无机杂化化合物，[Cu（4,4'-bipy）1.5（H 2 O）2 } 2 H 2 As 2 Mo 6 O 26 }]（1），[Cu（biim）2 } 2 HAs 2 Mo 6 O 26 } Cu（biim）Cl}]·H 2 O（2），（H 2 bib）[Cu（H 2 O）2（bib）} H 2 As 2 Mo 6 O 26 }]·2H 2 O（3），[（Hbix）Cu（bix）0.5 } 2 As 2 Mo 6 O 26 }]·2H 2 O（4），[Cu（bmb）1.5（H 2 O）} 2 H 2 As 2 Mo 6 O 26 }]·2H 2 O（5），0和[Cu 2（bth）4 } H 2 As 2 Mo 6 O 26 }]·H 2 O（6）（4,4'-联吡啶= 4,4'-联吡啶; biim =联咪唑; bib = 1,4-双（1-咪唑基）苯; bix
• Two Keggin-type arsenomolybdate organic-inorganic hybrid assemblies decorated by Cu-phen/bpy complexes for photo-/electro-catalytic performance
  作者：Yan-Feng Deng、Li-Ping Cui、Jing-Hua Lv、Yuan Guan、Yuhang Liu、Xingzhi Liu、Kai Yu

  DOI：10.1016/j.jssc.2020.121941

  日期：2021.3

  complexes, [ClCuII(phen)2}2]2[AsMo12O40]2·H2O (1) and [CuII(bpy)}CuII(bpy)2}2 (VIVO)2(AsMoVIMoV7VV4O40)]·H2O (2) (phen ​= ​1,10-phenanthroline, bpy ​= ​2,2′- bipyridyl), were obtained by hydrothermal reaction and structurally characterized via routine techniques. In compound 1, two “butterfly"-shaped Cu(phen)2} segments share a Cl bridge to form a unique binuclear complex unit Cl(Cu(phen)2)2}, which

  两个由Cu-phen / bpy配合物修饰的Keggin型砷钼酸杂化物[Cl Cu II（phen）2 } 2 ] 2 [AsMo 12 O 40 ] 2 ·H 2 O（1）和[Cu II（bpy） } Cu II（bpy）2 } 2（V IV O）2（AsMo VI Mo V 7 V V 4 O 40）]·H 2 O（2）（phen = 1,10-菲咯啉，bpy = 2,2'-联吡啶），是通过水热反应获得的，并通过常规技术进行结构表征。在化合物1中，两个“蝴蝶”形的Cu（phen）2 }段共享一个Cl桥，形成一个独特的双核复合单元Cl（Cu（phen）2）2 }，该单元进一步与六个AsMo 12 O 40 }通过氢键和其他弱相互作用形成簇，形成4,6连接的3D网络。2的基本单位是七电子还原的四-V-取代的Keggin聚氧阴离子AsMo VI Mo V 7 V V 4 O 40}，由Mo
• Two arsenic capped Dawson-type supramolecular hybrid assemblies induced by benzimidazole for photo-/electro-catalytic performance
  作者：Yuan Guan、Li-Ping Cui、Kai Yu、Jing-Hua Lv、Yan-Feng Deng、Chun-Mei Wang、Bai-Bin Zhou

  DOI：10.1016/j.jssc.2020.121707

  日期：2020.12

  interaction between O atom of Dawson cluster and N derived from Cu(biz)2} complex. In compound 2, bi-arsenic capped AsIII2As2Mo18 O62} cluster is connected to 17 biz and 3 ptz ligands, which are further attracted by 12 Dawson analogues to form a 12-connected 3D supramolecular net with a 324.433.59 topology via strong H-bonds and supramolecular interactions. Compound 2 represents the highest connectivity of

  两个砷封端的道森砷钼酸超分子混合组件（Cu（biz）2）12 [Cu I（H 2 O）2 As 0.5 III As 2 Mo V 2 Mo VI 16 O 62 } 2 ]·2H 2 O（1） （biz）6（ptz）As III 2 As 2 Mo 18 O 62 }·H 2 O（2）（biz =苯并咪唑，ptz = 5-（4-吡啶基）-四唑），已在水热条件下合成，并通过常规方法充分表征。在化合物1中，砷封端的As 0.5 As 2 Mo V 2 Mo VI 16 }团簇通过Cu（H 2 O）2接头相互键合形成直链，并进一步延伸为2D波形层，通过Dawson团簇的O原子与Cu（biz）2 }络合物衍生的N之间的类似超分子相互作用，具有1D通道的3D超分子网络。在化合物2中，双砷封顶了As III 2 As2 Mo 18 O 62 }团簇与17 biz和3 ptz配体相连，它们进一步被12
• Design and synthesis of malonohydrazide based colorimetric receptors for discrimination of maleate over fumarate and detection of F−, AcO− and AsO2− ions
  作者：Archana Singh、Makesh Mohan、Dharshak R. Trivedi

  DOI：10.1016/j.saa.2019.117883

  日期：2020.3

  have designed and synthesized two new organic receptors R1 and R2 based on malonohydrazide for the recognition of biologically important anions. The receptor R1 capable of colorimetric discrimination of maleate over fumarate ion, exhibit significant color change from pale yellow to wine red due to intermolecular hydrogen bond between the R1 and maleate ion, supported by 1HNMR titration, where the peak

  在这项研究中，我们已经设计和合成了基于丙二酰肼的两个新的有机受体R1和R2，用于识别生物学上重要的阴离子。能够比色富马酸根离子对马来酸根进行比色区分的受体R1由于R1和马来酸根离子之间的分子间氢键而显示出从浅黄色到酒红色的显着颜色变化，并由1HNMR滴定支持，其中δ12.0ppm的峰归因于NH质子与马来酸根离子结合后会发生低场迁移。受体R1带有两个吸电子NO2部分作为发色信号单元，可增强氢键结合趋势和酸度，因此与受体R2相比，R1的红移（Δλmax）更高，分别为148 nm，143 nm和140在DMSO中朝向F-，AcO-和马来酸根阴离子的最大距离。此外，合成的受体R1和R2能够检测水溶液中F-，AcO-和AsO2-离子的钠盐，并且颜色会发生明显变化。受体R1对F-和AcO-离子表现出电化学反应。受体R1和R2已成功应用于定量检测水性介质中牙膏溶液中的F-离子。此外，R1和R2对DMSO

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