白炭黑 | 10279-57-9

• 物质功能分类: 无机化工 - 硅胶
• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 类金属有机物
• 中文名称: 白炭黑
• 中文别名: 水合二氧化硅；水合二氧化硅；纯乳胶
• 英文名称: silicon dioxide hydrate
• 英文别名: silica hydrate；Hydrated Silica；dioxosilane;hydrate
• CAS: 10279-57-9
• 化学式: H₂O*O₂Si
• 分子量: 78.0996
• InChiKey: LRCFXGAMWKDGLA-UHFFFAOYSA-N

物化性质

• 熔点：
  1610 °C(lit.)
• 沸点：
  >100 °C(lit.)
• 密度：
  2.6 g/mL at 25 °C(lit.)
• 暴露限值：
  NIOSH: IDLH 3000 mg/m3; TWA 6 mg/m3

计算性质

• 辛醇/水分配系数(LogP)：
  -1.44
• 重原子数：
  4
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  35.1
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 危险品标志：
  Xn
• 安全说明：
  S22
• 危险类别码：
  R48/20
• WGK Germany：
  3
• 海关编码：
  2811 22 00
• RTECS号：
  VV7340000
• 储存条件：
  2-8°C

制备方法与用途

用途：

• 用作油漆和涂料的填充剂
• 橡胶补强剂
• 塑料增粘剂和触变剂
• 合成润滑脂和硅脂的稠化剂

反应信息

• 作为反应物：
  描述：

  白炭黑 、 5-<3-<<(dimethylethyl)diphenylsilyl>oxy>propyl>-3-isoxazolemethanol 在 溴 、 三苯基膦 作用下， 以 正己烷 、 二氯甲烷 、 水 为溶剂， 以3.38 g (93.9%)的产率得到3-bromomethyl-5-[3-(tert-butyldiphenylsilyloxy)propyl]isoxazole
  参考文献：
  名称：

  1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral

  摘要：

  公式为##STR1##的化合物，其中：R.sub.1为烷基，烷氧基，羟基，环烷基，羟基烷基，烷氧基烷基，羟基烷氧基，烷基硫代烷基，烷基亚砜基烷基，烷基磺酰基烷基，氨基烷基，烷基氨基烷基，二烷基氨基烷基，烷氧羰基，羧基或氰甲基；Y为碳原子数为3至9的烷基，R.sub.2和R.sub.3独立地为氢，烷基，烷氧基，卤素，氰基，三氟甲基和硝基；R.sub.4为烷氧基，羟基，卤甲基，二卤甲基，三卤甲基，二卤乙基，环烷基，杂环烷基，烷氧羰基，羟基烷基，烷氧基烷基，烷基羧酸酯氧基烷基，氰基，卤素，硫代烷基，烷基硫代烷基，烷基硫，硫，2,2,2-三氟乙基，(4-甲基苯基)磺酰氧甲基，N.dbd.Q或CON.dbd.Q，其中N.dbd.Q为氨基，烷基氨基或二烷基氨基；R.sub.5为氢或卤素或烷基。

  公开号：

  US05464848A1

文献信息

• 19-Hydroxy PGE.sub.1 carbinol analogues
  申请人：Miles Laboratories, Inc.

  公开号：US04127612A1

  公开（公告）日：1978-11-28

  19-Hydroxy carbinol analogues of PGE.sub.1 having the structure ##STR1## are disclosed as bronchodilators. Methods of preparing the analogues are also disclosed.

  19-羟基卡比诺类似物PGE.sub.1的结构如下所示##STR1##，被披露为支气管扩张剂。还披露了制备这些类似物的方法。
• Derivatives of benzofuran or benzodioxole
  申请人：Kyowa Hakko Kogyo Co., Ltd.

  公开号：US06514996B2

  公开（公告）日：2003-02-04

  An oxygen-containing heterocyclic compound represented by following Formula (I): wherein R1 and R2 independently represent hydrogen, lower alkyl, cyano, —(CH2)n—E1—CO—G1 (wherein E1 represents a bond, O, or NH; and G1 represents hydrogen, substituted or unsubstituted lower alkyl, OR6, or NR7R8; and n represents an integer of 0 to 4), or the like; R1 and R2 are combined to represent a saturated carbon ring together with a carbon atom adjacent thereto; or R2, and R11 or R13 described below are combined to form a single bond; R3 represents hydrogen, phenyl, or halogen; R4 represents hydroxy, lower alkoxy, or the like; A represents —C(R9)(R10)— or O; B represents O, NR11, —C(R12)(R13)—, or —C(R14)(R15)—C(R16)(R17)—; D represents (i) —C(R18)(R19)—X— (wherein X represents —C(R21)(R22)—, S, or NR23), (ii) —C(R19a)═Y— [Y represents —C(R24)—Z— (wherein Z represents CONH, CONHCH2, or a bond), or N], or (iii) a bond; and R5 represents aryl, an aromatic heterocyclic group, cycloalkyl, pyridine-N-oxide, cyano, or lower alkoxycarbonyl; or pharmaceutically acceptable salts thereof.

  根据您的要求，以下是该化学公式（I）的中文翻译： 一个含氧杂环化合物，由以下公式（I）表示：其中R1和R2独立代表氢、低级烷基、氰基、—(CH2)n—E1—CO—G1（其中E1代表一个键、O或NH；G1代表氢、取代或未取代的低级烷基、OR6或NR7R8；n代表0到4的整数），或类似物；R1和R2共同代表与相邻碳原子一起的饱和碳环；或者R2与下面描述的R11或R13结合形成一个单键；R3代表氢、苯基或卤素；R4代表羟基、低级烷氧基或类似物；A代表—C(R9)(R10)—或O；B代表O、NR11、—C(R12)(R13)—或—C(R14)(R15)—C(R16)(R17)—；D代表（i）—C(R18)(R19)—X—（其中X代表—C(R21)(R22)—、S或NR23）、（ii）—C(R19a)═Y— [Y代表—C(R24)—Z—（其中Z代表CONH、CONHCH2或一个键）或N]，或（iii）一个键；R5代表芳基、芳香杂环基、环烷基、吡啶-N-氧化物、氰基或低级烷氧基甲酸；或其药物可接受的盐。
• 2-[3-(Phthalimidomethyl)-5-methyl-4H-1,2,4-triazol-4-yl]benzophenones
  申请人：The Upjohn Company

  公开号：US03993660A1

  公开（公告）日：1976-11-23

  A process to make 6-phenyl-4H-s-triazolo[4,3-a][1,4]-benzodiazepines by converting 2-[3-(hydroxymethyl)-4H-1,2,4-triazol-4-yl]benzophenones to 2-[3-[(phthalimido or methanesulfonyl)methyl]-4H-1,2,4-triazol-4-yl]benzophenones and converting these compounds to the highly active 6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines useful as tranquilizers and sedatives.

  将2-[3-(羟甲基)-4H-1,2,4-三唑-4-基]苯酮转化为2-[3-[(邻苯二甲酰亚胺或甲磺酰基)甲基]-4H-1,2,4-三唑-4-基]苯酮，然后将这些化合物转化为作为镇静剂和催眠剂有用的高活性6-苯基-4H-s-三唑并[4,3-a][1,4]-苯二氮䓬。
• Substituted glutamic acids
  申请人：Burroughs Wellcome Co.

  公开号：US04940713A1

  公开（公告）日：1990-07-10

  The present invention provides a compound of formula (I): ##STR1## wherein R.sup.1 is hydrogen, C.sub.1-4 alkyl, acetyl or formyl; R.sup.2 and R.sup.3 are the same or different and are hydrogen or C.sub.1-4 alkyl; R.sup.4 is NR.sup.11 R.sup.12 ; R.sup.11, R.sup.12, R.sup.5 and R.sup.6 are the same or different and are hydrogen, C.sub.1-4 alkyl or C.sub.1-12 acyl; R.sup.7, R.sup.8, R.sup.9 and R.sup.10 are the same or different and are hydrogen, halo, C.sub.1-4 haloalkyl, C.sub.1-4 alkyl and C.sub.1-4 alkoxy; and n is 2, 3, 4 or 5; m is 0 or an integer from 1 to 6; or a salt thereof, methods for the preparation of the compounds of the formula (I), intermediates in their preparations, pharmaceutical formulations containing them, and their use in the treatment of tumors.

  本发明提供了一种化合物，其化学式为（I）：##STR1##其中R.sup.1为氢、C.sub.1-4烷基、乙酰基或甲酰基；R.sup.2和R.sup.3相同或不同，为氢或C.sub.1-4烷基；R.sup.4为NR.sup.11R.sup.12；R.sup.11、R.sup.12、R.sup.5和R.sup.6相同或不同，为氢、C.sub.1-4烷基或C.sub.1-12酰基；R.sup.7、R.sup.8、R.sup.9和R.sup.10相同或不同，为氢、卤素、C.sub.1-4卤代烷基、C.sub.1-4烷基和C.sub.1-4烷氧基；n为2、3、4或5；m为0或1至6的整数；或其盐，以及制备化合物（I）的方法，其制备中间体，含有它们的药物配方，以及它们在肿瘤治疗中的用途。
• Substituted 1-(2-chloroethyl)-3-acyl-3-alkyltriazenes
  申请人：Bionetics Research, Inc.

  公开号：US04923970A1

  公开（公告）日：1990-05-08

  A substituted 1-(2-chloroethyl)-3-acyl-3-alkyltriazene of the formula: ##STR1## in which R.sub.1 is 1-oxoalkyl containing from two to eight carbon atoms, fluorinated 1-oxoalkyls containing from two to eight carbon atoms and substituted with up to three fluorine atoms, benzoyl, phenylacetyl, carboalkoxy containing from two to eight carbon atoms, fluorinated carboalkyl containing from two to eight carbon atoms and up to three fluorine atoms, carbophenoxy, N-phenyl aminocarbonyl, N-alkyl aminocarbonyl containing from two to eight carbon atoms, thiocarbamoyl, N-alkylthiocarbamoyls with from two to eight carbon atoms, N-phenylthiocarbamoyl, dialkylphosphonates in which the alkyl groups can be the same or different and each contains from one to seven carbon atoms, phenylsulfonyl, and meta or para-substituted phenylsulfonyl in which the meta or para substituent is methyl, ethyl, methoxy, ethoxy, fluoro and chloro; and R.sub.2 is indepedently alkyl containing from one to seven carbon atoms, fluoroalkyl containing from two to seven carbon atoms and from one to three fluorine atoms in which the .alpha. carbon of the fluoroalkyl group is not substituted with fluorine, benzyl, meta or para-substituted benzyl in which the meta or para substituent is chloro, fluoro, and alkoxy with from one to three carbon atoms, alkenyl containing from two to seven carbon atoms, and alkynyl containing from two to seven carbon atoms, useful as antitumor agents.

  公式为：##STR1##，其中R.sub.1是1-氧代烷基，含有2至8个碳原子，含有最多三个氟原子的氟代1-氧代烷基，苯甲酰基，苯乙酰基，含有2至8个碳原子的羧基烷基，含有2至8个碳原子和最多三个氟原子的氟代羧基烷基，羰基苯氧基，N-苯基氨基甲酰基，含有2至8个碳原子的N-烷基氨基甲酰基，硫代氨基甲酰基，含有2至8个碳原子的N-烷基硫代氨基甲酰基，N-苯基硫代氨基甲酰基，二烷基磷酸酯，其中烷基基团可以相同也可以不同，每个含有1至7个碳原子，苯磺酰基，以及间位或对位取代的苯磺酰基，其中间位或对位取代基是甲基，乙基，甲氧基，乙氧基，氟和氯；R.sub.2是独立的烷基，含有1至7个碳原子，含有2至7个碳原子和1至3个氟原子的氟代烷基，其中氟代烷基群的α碳未被氟取代，苄基，间位或对位取代的苄基，其中间位或对位取代基是氯，氟和含有1至3个碳原子的烷氧基，含有2至7个碳原子的烯基，以及含有2至7个碳原子的炔基，作为抗肿瘤剂。