6-propyl-2-benzylamino-1-nonanol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 6-propyl-2-benzylamino-1-nonanol
• 英文别名: 2-(benzylamino)-6-propylnonan-1-ol
• 化学式: C₁₉H₃₃NO
• 分子量: 291.477
• InChiKey: HHMMBYKUHWKQGF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  21
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-propyl-2-benzylamino-1-nonanol 、 环氧乙烷 生成 N-benzyl-3-(4-propyl-heptyl)morpholine
  参考文献：
  名称：

  HERNESTAM, SVEN E. H.;NILSSON, NILS A.;LARS-OLOF, WILLARD

  摘要：

  DOI：

文献信息

• Method of treating plaque using morpholine compounds
  申请人：AB Ferrosan

  公开号：US04894221A1

  公开（公告）日：1990-01-16

  Novel morpholino compounds having the general formula ##STR1## wherein R.sub.1 is a straight or branched alkyl group containing 8 to 16 carbon atoms at the 2- or 3-position of the morpholino ring, and R.sub.2 is a straight or branched alkyl group containing 2 to 10 carbon atoms, substituted with a hydroxy group except in the alpha-position, the sum of the carbon atoms in the groups R.sub.1 and R.sub.2 being at least 10 and preferably 10 to 20; and pharmaceutically acceptable salts thereof. Compositions for the treatment of the oral cavity and especially the tooth surfaces containing the novel compound or a salt thereof, preferably from 0.1 to 5% by weight thereof. Use of the compounds to inhibit the formation of dental plaque or remove plaque already formed by application of the compound in an aqueous solution or a composition to the surfaces of the oral cavity, especially the surfaces of the teeth. Processes for the preparation of the compounds.

  具有一般式##STR1##的新型吗啡啶化合物，其中R.sub.1是在吗啡啶环的2-或3-位置含有8至16个碳原子的直链或支链烷基基团，R.sub.2是含有2至10个碳原子的直链或支链烷基基团，除α-位置外被一个羟基取代，基团R.sub.1和R.sub.2中碳原子的总和至少为10，最好为10至20；及其药用可接受的盐。含有该新型化合物或其盐的用于治疗口腔，特别是牙齿表面的组合物，其重量百分比优选为0.1至5％。使用这些化合物抑制牙菌斑的形成或通过将该化合物以水溶液或组合物的形式应用于口腔表面，特别是牙齿表面，来去除已经形成的牙菌斑。制备这些化合物的方法。
• Morpholino compounds and compositions
  申请人：AB Ferrosan

  公开号：US04636382A1

  公开（公告）日：1987-01-13

  Novel morpholino compounds having the general formula ##STR1## wherein R.sub.1 is a straight or branched alkyl group containing 8 to 16 carbon atoms at the 2- or 3-position of the morpholino ring, and R.sub.2 is a straight or branched alkyl group containing 2 to 10 carbon atoms, substituted with a hydroxy group except in the alpha-position, the sum of the carbon atoms in the groups R.sub.1 and R.sub.2 being at least 10 and preferably 10 to 20; and pharmaceutically acceptable salts thereof. Compositions for the treatment of the oral cavity and especially the tooth surfaces containing the novel compound or a salt thereof, preferably from 0.1 to 5% by weight thereof. Use of the compounds to inhibit the formation of dental plaque or remove plaque already formed by application of the compound in an aqueous solution or a composition to the surfaces of the oral cavity, especially the surfaces of the teeth. Processes for the preparation of the compounds.

  新型吗啡诺化合物具有以下通用公式##STR1##其中R.sub.1是2-或3-位置的含有8至16个碳原子的直链或支链烷基基团，R.sub.2是含有2至10个碳原子的直链或支链烷基基团，除了α-位置外还被羟基取代，基团R.sub.1和R.sub.2中碳原子的总和至少为10，最好为10至20；及其药学上可接受的盐。含有该新型化合物或其盐的用于治疗口腔，尤其是牙齿表面的组合物，最好含有0.1至5%的重量。使用这些化合物通过将其溶解在水溶液或组合物中并应用于口腔表面，尤其是牙齿表面，来抑制牙菌斑的形成或去除已经形成的牙菌斑。制备这些化合物的方法。
• Novel morpholino coumpounds
  申请人：AB Ferrosan

  公开号：EP0038785A1

  公开（公告）日：1981-10-28

  Novel morpholino compounds having the general formula wherein R1 is a straight or branched alkyl group containing 6 to 16 carbon atoms at the 2- or 3-position of the morpholino ring, and R2 is a straight or branched alkyl group containing 2 to 10 carbon atoms, substituted with a hydroxy group, the sum of the carbon atoms in the groups R1 and R2 being at least 10 and preferably 10 to 20; and pharmaceutically acceptable salts thereof. Compositions for the treatment of the oral cavity and especially the tooth surfaces containing the novel compound or a salt thereof, preferably from 0.1 to 5 % by weight thereof. Use of the compounds to inhibit the formation of dental plaque or remove plaque already formed by application of the compound in an aqueous solution or a composition to the surfaces of the oral cavity, especially the surfaces of the teeth. Processes for the preparation of the compounds.

  通式如下的新型吗啉基化合物 其中，R1 是在吗啉基环的 2 位或 3 位上含有 6 至 16 个碳原子的直链或支链烷基，R2 是含有 2 至 10 个碳原子并被羟基取代的直链或支链烷基，基团 R1 和 R2 中的碳原子之和至少为 10，最好为 10 至 20；及其药学上可接受的盐。含有新型化合物或其盐的治疗口腔特别是牙齿表面的组合物，按重量计，最好为 0.1%至 5%。通过在口腔表面，特别是牙齿表面施用水溶液或组合物中的化合物，抑制牙菌斑的形成或去除已经形成的牙菌斑。化合物的制备工艺。
• HERNESTAM, SVEN E. H.;NILSSON, NILS A.;LARS-OLOF, WILLARD
  作者：HERNESTAM, SVEN E. H.、NILSSON, NILS A.、LARS-OLOF, WILLARD

  DOI：——

  日期：——
• US4636382A
  申请人：——

  公开号：US4636382A

  公开（公告）日：1987-01-13