碱性红 1 - CAS号 989-38-8

物化性质

熔点：

215 °C
密度：

1.26
溶解度：

H2O：可溶，1mg/mL，暗红色
最大波长(λmax)：

528 nm
LogP：

0.1 at 24℃
稳定性/保质期：

在常温常压下保持稳定，应避免与氧化物接触。

计算性质

辛醇/水分配系数(LogP)：

4.2
重原子数：

34.0
可旋转键数：

7.0
环数：

4.0
sp3杂化的碳原子比例：

0.29
拓扑面积：

61.66
氢给体数：

2.0
氢受体数：

4.0

安全信息

TSCA：

Yes
危险品标志：

Xn
安全说明：

S26,S36/37/39
危险类别码：

R22
WGK Germany：

3
海关编码：

3204130000
危险品运输编号：

NONH for all modes of transport
RTECS号：

DH0175000
危险性防范说明：

P280,P305+P351+P338
危险性描述：

H302
储存条件：

请将容器密封保存，并存放在阴凉、干燥的地方。

SDS

SDS：dcada5840fa95f1a5f02f76634236fb7

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Name:	Rhodamine 6g Material Safety Data Sheet
Synonym:	Basic Red 1; C.I. 4516
CAS:	989-38-8

Section 1 - Chemical Product MSDS Name:Rhodamine 6g Material Safety Data Sheet
Synonym:Basic Red 1; C.I. 4516

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
989-38-8	Rhodamine 6G	ca. 100	213-584-9

Hazard Symbols: XN
Risk Phrases: 40

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Limited evidence of a carcinogenic effect.
Potential Health Effects
Eye:
May cause eye irritation. This product contains a cationic dye.
Similar dyes have caused permanent injury to the cornea and conjunctiva in documented exposure cases with human or rabbit eyes.
Skin:
May cause skin irritation.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea.
Inhalation:
May cause respiratory tract irritation.
Chronic:
May cause cancer according to animal studies.

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.

Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Avoid contact with skin and eyes. Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Use only in a chemical fume hood.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 989-38-8: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: brown
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: soluble
Specific Gravity/Density:
Molecular Formula: C28H31ClN2O3
Molecular Weight: 479.01

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Will not occur.

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 989-38-8: DH0175000 LD50/LC50:
Not available.
Carcinogenicity:
Rhodamine 6G - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION
Other No information available.

Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 40 Limited evidence of a carcinogenic effect.
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
S 36/37 Wear suitable protective clothing and
gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 989-38-8: 2
Canada
CAS# 989-38-8 is listed on Canada's DSL List.
CAS# 989-38-8 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 989-38-8 is listed on the TSCA inventory.

SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

化学性质

罗丹明6G：又名玫瑰红6G、碱性红1，是一种红色或黄棕色粉末。其水溶液呈猩红色并带有绿色荧光；溶于醇时则呈现红色并带有黄色或黄红色带绿色荧光。罗丹明6G以三种形式存在：氯盐为红棕色的粉末，化学式可表示为 C27H29ClN2O3。这种形式易溶于多种溶剂，但对不锈钢有强腐蚀性；其他两种形式较难溶解，但仍具一定的腐蚀性。

罗丹明6G过氯酸盐（C27H29ClN2O7）为红色晶体，而四氟硼化物则呈现栗色晶体。该染料的化学性质多样且复杂，对于了解其荧光特性和应用范围具有重要意义。

结构性能

罗丹明6G（Rhodamine 6G，R6G）是一种水溶性阳离子荧光染料，在紫外光下发出绿黄色荧光；在碱性溶液中显暗绿色荧光；乙醇溶液呈现红黄色并带有绿黄色荧光。它被广泛应用于荧光标记或定量分析。

罗丹明6G的分子结构以氧杂蒽为母体，苯环间由“氧桥”相联，形成一个刚性的平面结构，属于呫吨类型的阳离子染料。其光物理性质主要取决于染料分子所处环境（如pH、极性及电荷等），这主要通过呫吨环π-电子体系影响氨基正电荷的离域化来实现。

研究这些特性有助于提高和控制荧光性能，广泛应用于生化研究中，例如生成离子缔合物用于金属离子测定、吸附指示剂以及生物染色剂等。

用途

罗丹明6G是广泛应用于光学、光谱学及激光科学的有机染料。1980年徐其亨对这类染料进行了综合研究和归纳，认为它们具有刚性平面结构，并且容易吸收能量而发射长波荧光，奠定了荧光分析和光度分析的理论基础。

罗丹明6G常被用作观察水中流速、水流方向及传递过程中的追踪染剂。由于其荧光性质显著，可利用廉价的荧光计进行简易检测。它在生物技术中有着广泛的应用，如荧光显微镜、流式细胞术、荧光相关光谱以及酵素结合免疫吸附分析法（ELISA）。

制备 罗丹明575(异构体1a)的合成

以3-乙氨基-5-甲基苯酚 (Ⅱ) 22.65g (150mmol) 和邻苯二甲酸酐 22.2g (150mmol)，溶于250mL氯苯中，加入ZnCl₂ 17.6g，充氮气，在190℃反应6h后冷却、过滤并干燥。用甲醇-氯仿(1∶1)混合溶液重结晶，得到紫色固体 (1a) 16.7g。

罗丹明6G(异构体1b)的合成

以 (1a) 33.2g (80mmol)，溶于乙醇中进行酯化反应后冷却。加入四氟硼酸钾1mol/L水溶液100mL，生成沉淀并过滤干燥。用甲醇重结晶，得紫色固体 (1b) 31.5g。

罗丹明6G还可用作染料和颜料，如适用于染蚕丝及羊毛、棉纤维等。它也可用于皮革、纸张着色，并在制造高级油墨的颜料时与磷钨钼酸反应生成色淀。此外，还可用于腈纶、毛、丝的染色。

化学性质上，罗丹明6G是一种暗绿紫红色闪光结晶，在水中呈带绿色荧光的猩红色；溶于乙醇时为带黄色荧光的红色；在浓硫酸中呈现黄色，稀释后变为红色。其水溶液加入氢氧化钠会产生猩红色沉淀。

用途上，碱性红 6G DN 适用于染蚕丝以及蚕丝织物直接印花。一般用于中性、酸性直接染料多色套印中作点缀色彩之用，不印大、中块面花型；在染羊毛、棉纤维时，色牢度较差。

生产方法上，罗丹明6G以 3-乙氨基对甲苯酚 (p-cresol, 3-ethylamino) 和苯酐为原料，首先将两者缩合，然后再用乙醇进行酯化即得产物。

反应信息

作为反应物：

描述：

碱性红 1 在 N,N-二异丙基乙胺、 sodium iodide 作用下，以乙腈为溶剂，反应 29.0h，生成 rhodamine 19 ethoxycarbonylmethyl ester bromide

参考文献：

名称：

An Expedient Synthesis of Cationic Rhodamine Fluorescent Probes Suitable for Conjugation to Amino Acids and Peptides

摘要：

罗丹明19苄氧羰甲基酯溴化物8和罗丹明19-4-氯甲基-1-苯甲基酯氯化物12作为阳离子荧光探针的前体。分别含有自由胺或羧酸盐官能团的分子可以通过一步法连接，从而得到所需的探针，无需进行色谱纯化。作为一种概念验证，该方法被应用于通过N端或C端连接氨基酸和二肽残基。前体分子8和12很容易从廉价、商业上可获得的染料罗丹明6G合成得到。

DOI：

10.1055/s-2003-42475
作为产物：

描述：

alkaline earth salt of/the/ methylsulfuric acid 在乙醇、硫酸作用下，生成碱性红 1

参考文献：

名称：

了解单乙基邻甲苯胺和从中可获得的一些若丹明

摘要：

DOI：

10.1002/hlca.193401701180
作为试剂：

描述：

ethyl (2-mercaptophenyl)glycinate 在碱性红 1 、 copper(II) bis(trifluoromethanesulfonate) 作用下，以二氯甲烷为溶剂，以92 %的产率得到1,3-苯并噻唑-2-羧酸乙酯

参考文献：

名称：

一种2-取代苯并噻唑化合物的制备方法

摘要：

本发明公开了一种2‑取代苯并噻唑化合物的制备方法，包括如下步骤：先按照摩尔比1：0.2：0.02取巯基苯基甘氨酸衍生物、路易斯酸和光催化剂，将其依次加入有机溶剂中，利用可见光照射，于空气中，在室温条件下搅拌至充分反应，再利用减压蒸馏去除有机溶剂，然后采用柱层析得到2‑取代苯并噻唑化合物。本发明具有反应条件温和、绿色、低成本和高效的优点。

公开号：

CN117720479A

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文献信息

[EN] ELECTROCHEMICALLY-CLEAVABLE LINKERS<br/>[FR] LIEURS CLIVABLES PAR VOIE ÉLECTROCHIMIQUE

申请人：MICROSOFT TECHNOLOGY LICENSING LLC

公开号：WO2021158412A1

公开（公告）日：2021-08-12

This disclosure provides electrochemically-cleavable linkers with cleavage potentials that are less than the redox potential of the solvent in which the linkers are used. In some applications, the solvent may be water or an aqueous buffer solution. The linkers may be used to link a nucleotide to a bound group. The linkers include a cleavable group which may be one of a methoxybenzyl alcohol, an ester, a propargyl thioether, or a trichloroethyl ether. The linkers may be cleaved in solvent by generating an electrode potential that is less than the redox potential of the solvent. In some implementations, an electrode array may be used to generate localized electrode potentials which selectively cleave linkers bound to the activated electrode. Uses for the linkers include attachment of blocking groups to nucleotides in enzymatic oligonucleotide synthesis.

这份披露提供了具有低于使用的溶剂的氧化还原电位的可电化学裂解连接物。在某些应用中，溶剂可能是水或水溶液缓冲液。这些连接物可用于将核苷酸连接到结合基团。连接物包括可裂解基团，可能是甲氧基苯甲醇、酯、丙炔硫醚或三氯乙基醚中的一种。通过产生低于溶剂的氧化还原电位的电极电位，可以在溶剂中裂解这些连接物。在某些实施中，可以使用电极阵列来产生局部电极电位，从而选择性地裂解与激活电极结合的连接物。这些连接物的用途包括在酶催化寡核苷酸合成中将阻断基团附着到核苷酸上。
IRAK DEGRADERS AND USES THEREOF

申请人：Kymera Therapeutics, Inc.

公开号：US20190192668A1

公开（公告）日：2019-06-27

The present invention provides compounds, compositions thereof, and methods of using the same.

本发明提供了化合物、其组合物以及使用这些化合物的方法。
[EN] FLUOROPHORE COMPOUNDS<br/>[FR] COMPOSÉS FLUOROPHORES

申请人：VERSITECH LTD

公开号：WO2009121244A1

公开（公告）日：2009-10-08

Provided herein are fluorophore compounds including rhodol and rhodamine compounds which can be used as fluorescent labels and/or fluorogenic probes and methods of making same. Provided also herein are methods that can be used to track, measure, detect, or screen biological species such as protein, DNA, enzyme, antibody, organelle, cell, tissue, drug, hormone, nucleotide, nucleic acid, polysaccharide or lipid in living organisms. Specifically, the methods include the steps of contacting any of the fluorophore compounds, rhodol compounds and rhodamine compounds disclosed herein with the biological species to form one or more fluorescent compounds, and measuring fluorescence properties of the fluorescent compounds. Provided also herein are high-throughput screening fluorescent methods for detecting or screening biological species.

本文提供了包括罗多尔和罗丹明化合物在内的荧光物质，可用作荧光标记剂和/或荧光探针，并提供了制备这些化合物的方法。本文还提供了可用于跟踪、测量、检测或筛选蛋白质、DNA、酶、抗体、细胞器、细胞、组织、药物、激素、核苷酸、核酸、多糖或脂质等生物种类在活体中的方法。具体而言，这些方法包括将本文披露的任何荧光物质、罗多尔化合物和罗丹明化合物与生物种类接触以形成一个或多个荧光化合物，并测量荧光化合物的荧光特性。本文还提供了用于检测或筛选生物种类的高通量筛选荧光方法。
[EN] COMPOUNDS USEFUL FOR TREATING NEURODEGENERATIVE DISORDERS<br/>[FR] COMPOSÉS UTILES POUR LE TRAITEMENT DE TROUBLES NEURODÉGÉNÉRATIFS

申请人：SATORI PHARMACEUTICALS INC

公开号：WO2011109657A1

公开（公告）日：2011-09-09

As described herein, the present invention provides compounds useful for treating or lessening the severity of a neurodegenerative disorder. The present invention also provides methods of treating or lessening the severity of such disorders wherein said method comprises administering to a patient a compound of the present invention, or composition thereof. Said method is useful for treating or lessening the severity of, for example, Alzheimer's disease.

如本文所述，本发明提供了用于治疗或减轻神经退行性疾病严重程度的化合物。本发明还提供了治疗或减轻此类疾病严重程度的方法，其中所述方法包括向患者施用本发明的化合物或其组合物。该方法适用于治疗或减轻例如阿尔茨海默病等疾病的严重程度。
[EN] IRAK DEGRADERS AND USES THEREOF<br/>[FR] AGENTS DE DÉGRADATION D'IRAK ET LEURS UTILISATIONS

申请人：KYMERA THERAPEUTICS INC

公开号：WO2020264499A1

公开（公告）日：2020-12-30

The present invention provides compounds, compositions thereof, and methods of using the same. The compounds include an IRAK binding moiety capable of binding to IRAK4 and a degradation inducing moiety (DIM). The DIM could be DTM a ligase binding moiety (LBM) or lysine mimetic. The compounds could be useful as IRAK protein kinase inhibitors and applied to IRAK mediated disorders.

本发明提供了化合物、其组合物以及使用这些化合物的方法。这些化合物包括能够结合到IRAK4的IRAK结合基团和诱导降解的基团（DIM）。DIM可以是DTM、一个连接酶结合基团（LBM）或赖氨酸类似物。这些化合物可以作为IRAK蛋白激酶抑制剂，并应用于IRAK介导的疾病。

碱性红 1 | 989-38-8

物质功能分类

分子结构分类

物化性质

计算性质

安全信息

SDS

制备方法与用途

反应信息

文献信息

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