5-(4-methylphenyl)-N-(4-sulfamoylphenyl)-1,2-oxazole-3-carboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-(4-methylphenyl)-N-(4-sulfamoylphenyl)-1,2-oxazole-3-carboxamide
• 化学式: C₁₇H₁₅N₃O₄S
• mdl: MFCD12915006
• 分子量: 357.39
• InChiKey: JPPWLXZMKLSIAI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  124
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  5-(p-tolyl)-isoxazole-3-carbonyl chloride 、 磺胺 在 三乙胺 作用下， 以 乙醚 为溶剂， 以88%的产率得到5-(4-methylphenyl)-N-(4-sulfamoylphenyl)-1,2-oxazole-3-carboxamide
  参考文献：
  名称：

  Functionally Substituted Isothiazole- and Isoxazolecarboxamides

  摘要：

  Convenient synthetic approaches to functionally substituted 5-phenyl-1,2-oxazole-3-carboxamides and 4,5-dichloro-1,2-thiazole-3-carboxamides were developed on the basis of reactions of the corresponding carboxylic acid chlorides with primary aromatic and aliphatic amines. Optimal ratios acid chlorideamine (or amine hydrochloride)-triethylamine were found so that the reaction did not involve active chlorine atom in position 5 of the isothiazole ring.

  DOI：

  10.1134/s1070428019040079

文献信息

• Functionally Substituted Isothiazole- and Isoxazolecarboxamides
  作者：E. A. Dikusar、S. K. Petkevich、N. A. Zhukovskaya、T. D. Zvereva、P. V. Kurman

  DOI：10.1134/s1070428019040079

  日期：2019.4

  Convenient synthetic approaches to functionally substituted 5-phenyl-1,2-oxazole-3-carboxamides and 4,5-dichloro-1,2-thiazole-3-carboxamides were developed on the basis of reactions of the corresponding carboxylic acid chlorides with primary aromatic and aliphatic amines. Optimal ratios acid chlorideamine (or amine hydrochloride)-triethylamine were found so that the reaction did not involve active chlorine atom in position 5 of the isothiazole ring.