4'-hydroxy-3,5-dimethoxytolan | 1262126-44-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4'-hydroxy-3,5-dimethoxytolan
• 英文别名: 4'-hydroxy-3,5-dimethoxydiphenylacetylene；4-(3,5-Dimethoxy-phenylethynyl)-phenol；4-[2-(3,5-dimethoxyphenyl)ethynyl]phenol
• CAS: 1262126-44-2
• 化学式: C₁₆H₁₄O₃
• 分子量: 254.285
• InChiKey: BAVJECZRJZRTHJ-UHFFFAOYSA-N

物化性质

• 沸点：
  448.2±45.0 °C(Predicted)
• 密度：
  1.22±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-溴苯酚 、 3,5-二甲氧基苯乙炔 在 palladium 10% on activated carbon 四氢吡咯 、 三苯基膦 作用下， 反应 17.0h， 以28%的产率得到4'-hydroxy-3,5-dimethoxytolan
  参考文献：
  名称：

  [EN] PROCESS FOR THE PRODUCTION OF SUBSTITUTED ELECTRON RICH DIPHENYLACETYLENES
  [FR] PROCÉDÉ POUR LA PRODUCTION DE DIPHÉNYLACÉTYLÈNES RICHES EN ÉLECTRONS SUBSTITUÉS

  摘要：

  公开号：

  WO2011009888A3

文献信息

• Formulation and process for modulating wound healing
  申请人：BioMendics, LLC

  公开号：US10426742B2

  公开（公告）日：2019-10-01

  Methods and compounds are disclosed for wound healing by modulating autophagy. A formulation for modulating autophagy comprises a first modulating compound (FAM) selected from compounds having the general structure (I): wherein: L represents a linker selected from —C≡C—, (a tolan), —CH═CH— (a stilbene, preferably trans); or —CRa═CRb— a stilbene derivative; where Ra and Rb are independently H or phenyl optionally substituted with —(R3)p or —(R4)q; R1 to R4 are independent substituents at any available position of the phenyl rings, preferably at 3, 3′, 4, 4′, and/or 5, 5′; and m, n, p, and q are independently 0, 1, 2, or 3 representing the number of substituents of the rings, respectively, but at least one of m or n must be ≥1. Each R1 to R2 is independently selected from substituents described herein, including but not limited to hydroxyl, alkoxy, halo, halomethyl and glycosides. The formulation may also include an auxiliary autophagy modulating compound (AAM) as described herein. The formulation may include a hydrogel formed by the compounds themselves or otherwise and may include salts and/or complexes.

  本发明公开了通过调节自噬促进伤口愈合的方法和化合物。用于调节自噬的制剂包括选自具有一般结构 (I) 的化合物的第一调节化合物 (FAM)： 其中L 代表选自-C≡C-（甲苯）、-CH═CH-（二苯乙烯，最好是反式）或-CRa═CRb-二苯乙烯衍生物的连接体；其中 Ra 和 Rb 独立地是 H 或任选被-(R3)p 或-(R4)q 取代的苯基； R1至R4是独立的取代基，位于苯基环的任何可用位置，优选位于3，3′、4，4′和/或5，5′；m、n、p和q分别独立地为0、1、2或3，代表环的取代基数目，但m或n中至少有一个必须≥1。每个 R1 至 R2 独立地选自本文所述的取代基，包括但不限于羟基、烷氧基、卤代、卤代甲基和苷。制剂还可包括本文所述的辅助自噬调节化合物（AAM）。制剂可包括由化合物本身或以其它方式形成的水凝胶，并可包括盐和/或复合物。
• Substituted tolans for the modulation of microbial colonization
  申请人：BioMendics, LLC

  公开号：US11351126B2

  公开（公告）日：2022-06-07

  Described are methods for disinfecting a physical or biological surface by contact with an antimicrobial formulation comprising a substituted tolan compound, the substitutions being, for example, one or more alkoxy, (e.g., methoxy) and hydroxy substituents at one or both phenyl rings of the tolan. The compounds and methods are -static and/or -cidal, depending on dose and suspected microbe. Suspected pathogenic microbes include Gram negative bacteria, such as P. aeruginosa and E. coli, Gram positive bacteria, such as S. aureus, including MRSA, and fungal pathogens, such as Candida genus and C. albicans. Also described are methods for inhibiting or disrupting biofilm formation of a microbe or microbes.

  本发明描述了通过与抗菌制剂接触对物理或生物表面进行消毒的方法，该抗菌制剂包含取代的妥仑化合物，取代基为妥仑的一个或两个苯基环上的一个或多个烷氧基（如甲氧基）和羟基取代基。根据剂量和可疑微生物的不同，化合物和方法具有静止和/或杀灭作用。疑似病原微生物包括革兰氏阴性菌，如绿脓杆菌和大肠杆菌；革兰氏阳性菌，如金黄色葡萄球菌，包括 MRSA；以及真菌病原体，如白色念珠菌属和白色念珠菌。还描述了抑制或破坏一种或多种微生物的生物膜形成的方法。
• PROCESS FOR THE PRODUCTION OF SUBSTITUTED ELECTRON RICH DIPHENYLACETYLENES
  申请人：DSM IP Assets B.V.

  公开号：EP2456742A2

  公开（公告）日：2012-05-30
• Formulation and Process for Modulating Wound Healing
  申请人：BioMendics, LLC

  公开号：US20160296477A1

  公开（公告）日：2016-10-13

  Methods and compounds are disclosed for wound healing by modulating autophagy. A formulation for modulating autophagy comprises a first modulating compound (FAM) selected from compounds having the general structure (I): wherein: L represents a linker selected from —C≡C—, (a tolan), —CH═CH— (a stilbene, preferably trans); or —CR a ═CR b — a stilbene derivative; where R a and R b are independently H or phenyl optionally substituted with —(R 3 ) p or —(R 4 ) q ; R 1 to R 4 are independent substituents at any available position of the phenyl rings, preferably at 3, 3′, 4, 4′, and/or 5, 5′; and m, n, p, and q are independently 0, 1, 2, or 3 representing the number of substituents of the rings, respectively, but at least one of m or n must be ≧1. Each R 1 to R 2 is independently selected from substituents described herein, including but not limited to hydroxyl, alkoxy, halo, halomethyl and glycosides. The formulation may also include an auxiliary autophagy modulating compound (AAM) as described herein. The formulation may include a hydrogel formed by the compounds themselves or otherwise and may include salts and/or complexes.
• Substituted Tolans for the Modulation of Microbial Colonization
  申请人：BioMendics, LLC

  公开号：US20200206154A1

  公开（公告）日：2020-07-02

  Described are methods for disinfecting a physical or biological surface by contact with an antimicrobial formulation comprising a substituted tolan compound, the substitutions being, for example, one or more alkoxy, (e.g., methoxy) and hydroxy substituents at one or both phenyl rings of the tolan. The compounds and methods are -static and/or -cidal, depending on dose and suspected microbe. Suspected pathogenic microbes include Gram negative bacteria, such as P. aeruginosa and E. coli , Gram positive bacteria, such as S. aureus , including MRSA, and fungal pathogens, such as Candida genus and C. albicans . Also described are methods for inhibiting or disrupting biofilm formation of a microbe or microbes.