(E)-hex-1-enyl 2-phenylacetate | 1440548-61-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-hex-1-enyl 2-phenylacetate
• 英文别名: Hexenylphenylacetat；[(E)-hex-1-enyl] 2-phenylacetate
• CAS: 1440548-61-7
• 化学式: C₁₄H₁₈O₂
• 分子量: 218.296
• InChiKey: NUXQPAWSLNNHIJ-DHZHZOJOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  苯乙酸 、 potassium (E)-1-hexenyl trifluoroborate 在 4-二甲氨基吡啶 、 氧气 、 copper(I) bromide 作用下， 以 乙腈 为溶剂， 反应 24.0h， 以94%的产率得到(E)-hex-1-enyl 2-phenylacetate
  参考文献：
  名称：

  铜催化烯基三氟硼酸盐与羧酸或羧酸盐的非脱羧交叉偶联：烯醇酯的合成

  摘要：

  描述了一种轻度铜催化的Chan-Lam-Evans型交叉偶联反应，用于区域选择性和立体定向制备（E）-或（Z）-烯醇酯。该方法在60°C的O 2下，在具有催化作用的CuBr和DMAP和4Å分子筛的存在下，将羧酸盐或羧酸与链烯基三氟硼酸钾盐偶合。总的来说，该方法证明了羧酸是适合非脱羧铜催化的交叉偶联反应的合适反应伙伴，可在类Ullmann反应中形成C-O键。

  DOI：

  10.1021/ol4013712

文献信息

• Pharmaceutical compositions comprising flavonoids and menthol
  申请人：Berg Frimann Kurt

  公开号：US20060148726A1

  公开（公告）日：2006-07-06

  The present invention relates to use of certain antiviral fragrances for reduction of viruses, in particular vira causing common cold. In one embodiment, the invention relates to pharmaceutical compositions comprising an antiviral fragrance, preferably menthol. Said compositions preferably also comprise one or more flavonoids. The invention also relates to treatment of common cold using said compositions.

  本发明涉及使用某些抗病毒香料来减少病毒，特别是引起普通感冒的病毒。在一个实施方案中，本发明涉及包含抗病毒香料（最好是薄荷醇）的药物组合物。所述组合物最好还包含一种或多种类黄酮。本发明还涉及使用所述组合物治疗普通感冒。
• MITSUDO, TAKE-AKI;HORI, YOJI;YAMAKAWA, YASUSHI;WATANABE, YOSHIHISA, TETRAHEDRON LETT., 1986, 27, N 19, 2125-2126
  作者：MITSUDO, TAKE-AKI、HORI, YOJI、YAMAKAWA, YASUSHI、WATANABE, YOSHIHISA

  DOI：——

  日期：——
• PHARMACEUTICAL COMPOSITIONS COMPRISING FLAVONOIDS AND MENTHOL
  申请人：Immupharm A/S

  公开号：EP1556021B1

  公开（公告）日：2007-12-19
• PEROXIDE-STABILIZED ABRASIVE TOOTH WHITENING COMPOSITIONS, PROCESS FOR PREPARING AND METHOD OF USE
  申请人：Prosise William E.

  公开号：US20120301522A1

  公开（公告）日：2012-11-29

  Disclosed herein is a water-based, peroxide-stabilized, abrasive tooth whitening composition comprising: (i) a peroxide-polymer complex comprising (a) a peroxide component or a peroxide generating component; and (b) a vinyl lactam based polymer; (ii) coated abrasive particles; and one or more orally acceptable carriers. This application also provides methods for whitening the tooth surfaces by contacting with the compositions. Additionally disclosed is a process for preparing the compositions.
• ALCOHOL-FREE SLIGHTLY-ALCOHOLIC ORAL CARE COMPOSITION AND A PROCESS FOR PREPARING SAME
  申请人：Kolazi Narayanan S.

  公开号：US20130224125A1

  公开（公告）日：2013-08-29

  An aqueous, heat and cold stable, non-alcoholic or slightly-alcoholic microemulsion based antimicrobial mouthwash composition with improved antimicrobial efficacy. The composition comprises a unique water-soluble matrix composite, at least one water-immiscible or water-insoluble antimicrobial agent, and optionally, a preservative or preservative system, a weak carboxylic acid, a coloring agent and other additives. Examples of antimicrobial agents include menthol, thymol, eucalyptol and/or methyl salicylate. A process for preparing the oral care composition is also disclosed.