9-Carbamoyl-9-(2-cyanoethyl)fluorenes (I) are intermediates for synthesis of 9-aminoalkyl-9-carbamoyl- fluoroenes (II), which are antiarrhythmic agents.
In (I) and (II) R and R' are independently hydrogen, C1-C4 alkyl, fluoro of chloro; R4 and R5 are independently hydrogen or C1-C6, alkyl, and R2and R3 independently are hydrogen, C1C6 alkyl, CH2 (C2-C5 alkenyl), phenyl (C1-C3 alkyl), or taken together with the nitrogen to which they are attached are a cyclic group of the formula
wherein R6 is hydrogen or C, - C4 alkyl; A is -CH2-, oxygen or -NH-; and Y is zero or one; or a pharmaceutically acceptable salt thereof.
9-
氨基甲酰基-9-(2-
氰乙基)
芴(I)是合成 9-
氨基烷基-9-
氨基甲酰基-
芴(II)的中间体,而 9-
氨基烷基-9-
氨基甲酰基-
芴(II)是
抗心律失常药物。
在 (I) 和 (II) 中,R 和 R' 独立地为氢、C1-C4 烷基、
氟或
氯;R4 和 R5 独立地为氢或 C1-C6 烷基,R2 和 R3 独立地为氢、C1-C6 烷基、
CH2(C2-C5 烯基)、苯基(C1-C3 烷基),或与它们所连接的氮一起组成式中的环状基团。
其中 R6 为氢或 C,- C4 烷基;A 为- -、氧或-NH-;Y 为 0 或 1;或其药学上可接受的盐。