N-(4-cyanobenzoyl)-2-hydroxybenzamide | 1262725-52-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-cyanobenzoyl)-2-hydroxybenzamide
• 英文别名: MP-IV-32；N-(4-cyanobenzoyl)-2-hydroxy-benzamide
• CAS: 1262725-52-9
• 化学式: C₁₅H₁₀N₂O₃
• 分子量: 266.256
• InChiKey: DFSIKDHVTGCUCB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  90.2
• 氢给体数：
  2
• 氢受体数：
  4

上下游信息

• 上游原料

  中文名称	英文名称	CAS号	化学式	分子量
  水杨酰胺	salicylamide	65-45-2	C7H7NO2	137.138

反应信息

• 作为反应物：
  描述：

  N-(4-cyanobenzoyl)-2-hydroxybenzamide 在 硫酸 、 三乙胺 作用下， 以 乙腈 为溶剂， 反应 4.0h， 以95%的产率得到4-(4-Oxo-1,3-benzoxazin-2-yl)benzonitrile
  参考文献：
  名称：

  NEW TRIAZINE DERIVATIVE, ULTRAVIOLET ABSORBER, AND RESIN COMPOSITION

  摘要：

  公开号：

  EP2460799B1
• 作为产物：
  描述：

  对氰基苯甲酰氯 、 水杨酰胺 在 吡啶 作用下， 反应 4.0h， 以91%的产率得到N-(4-cyanobenzoyl)-2-hydroxybenzamide
  参考文献：
  名称：

  Synthesis, Biological Evaluation, and Structure–Activity Relationships of N-Benzoyl-2-hydroxybenzamides as Agents Active against P. falciparum (K1 strain), Trypanosomes, and Leishmania

  摘要：

  In our efforts to identify novel chemical scaffolds for the development of new antiprotozoal drugs, a compound library was screened against Toxoplasma gondii tachyzoites with activity discovered for N-(4-ethylbenzoyl)-2-hydroxybenzamide la against T. gondii as described elsewhere. Synthesis of a compound set was guided by T. gondii SAR with 1r found to be superior for T. gondii, also active against Thai and Sierra Leone strains of Plasmodium falciparum, and with superior ADMET properties as described elsewhere. Herein, synthesis methods and details of the chemical analysis of the compounds in this series are described. Further, this series of N-benzoyl-2-hydroxybenzamides was repurposed for testing against four other protozoan parasites: Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani, and P. falciparum (K1 isolate). Structure-activity analyses led to the identification of compounds in this set with excellent antileishmanial activity (compound 1d). Overall, compound 1r was the best and had activity 21-fold superior to that of the standard antimalarial drug chloroquine against the K1 P. falciparum isolate.

  DOI：

  10.1021/jm2015183

文献信息

• POLYCARBONATE RESIN COMPOSITION CONTAINING TRIAZINE COMPOUND AND MOLDED ARTICLE USING THE SAME
  申请人：Kitagawa Takashi

  公开号：US20110077331A1

  公开（公告）日：2011-03-31

  A polycarbonate resin composition comprising a compound represented by the following formula (1): wherein each of R 1a , R 1b , R 1c , R 1d and R 1e independently represents a hydrogen atom or a monovalent substituent provided that OH is excluded, at least one of the substituents represents a substituent having a Hammett's σp value of 0.3 or more, and the substituents may be combined each other to form a ring; and each of R 1g , R 1h , R 1i , R 1j , R 1k , R 1m , R 1n and R 1p independently represents a hydrogen atom or a monovalent substituent, and the substituents may be combined each other to form a ring.
• POLYESTER RESIN COMPOSITION
  申请人：Watanabe Yukie

  公开号：US20120301696A1

  公开（公告）日：2012-11-29

  To provide a polyester resin composition being able to maintain a long-wavelength ultraviolet-blocking effect for a long period of time, ensuring high solubility for a solvent, and having excellent light resistance. A polyester resin composition comprising a compound represented by the following formula (1) and a polyester resin: wherein each of R 1a , R 1b , R 1c , R 1d and R 1e independently represents a hydrogen atom or a monovalent substituent excluding OH, at least one of the substituents represents a substituent having a positive Hammett's σp value, and the substituents may combine with each other to form a ring; and each of R 1g , R 1h , R 1i , R 1j , R 1k , R 1m , R 1n and R 1p independently represents a hydrogen atom or a monovalent substituent, and the substituents may combine with each other to form a ring.
• US8623990B2
  申请人：——

  公开号：US8623990B2

  公开（公告）日：2014-01-07
• US8748520B2
  申请人：——

  公开号：US8748520B2

  公开（公告）日：2014-06-10
• US8957140B2
  申请人：——

  公开号：US8957140B2

  公开（公告）日：2015-02-17