1,2-二(2-羟基苯基)-1,2-乙烷二酮 | 85-26-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 中文名称: 1,2-二(2-羟基苯基)-1,2-乙烷二酮
• 英文名称: 2,2'-dihydroxybenzil
• 英文别名: 2,2’-dihydroxy benzil；Bis(2-hydroxyphenyl)ethane-1,2-dione；1,2-bis(2-hydroxyphenyl)ethane-1,2-dione
• CAS: 85-26-7
• 化学式: C₁₄H₁₀O₄
• 分子量: 242.231
• InChiKey: AGAURCCLJKMAEJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2914501900

反应信息

• 作为反应物：
  描述：

  1,2-二(2-羟基苯基)-1,2-乙烷二酮 在 溴 、 溶剂黄146 作用下， 生成 双溴水杨酰
  参考文献：
  名称：

  Kuhn; Birkofer; Moeller, Chemische Berichte, 1943, vol. 76, p. 900,903

  摘要：

  DOI：
• 作为产物：
  描述：

  2-羟基-1,2-双(2-羟基苯基)乙酮 在 copper(ll) sulfate pentahydrate 、 三乙胺 作用下， 以 水 、 乙腈 为溶剂， 反应 0.17h， 以80.8%的产率得到1,2-二(2-羟基苯基)-1,2-乙烷二酮
  参考文献：
  名称：

  Highly selective recognition of fluoride anion through direct deprotonation of intramolecularly hydrogen-bonded phenolic hydroxyl groups

  摘要：

  A novel chemosensor for fluoride anion has been developed. This sensor, constructed by merging six phenolyl units into a hexaazatriphenylene (HAT) core, could recognize F- visually and spectroscopically with high selectivity over other anions, which was demonstrated by naked-eye experiment and UV-vis absorption spectroscopy study. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.07.021

文献信息

• [EN] CARBON MONOXIDE RELEASING NORBORNENONE COMPOUNDS<br/>[FR] COMPOSÉS DE NORBORNÉNONE LIBÉRANT DU MONOXYDE DE CARBONE
  申请人：SAMMUT IVAN ANDREW

  公开号：WO2017095237A1

  公开（公告）日：2017-06-08

  The present invention provides organic compounds which are capable of releasing carbon monoxide under physiological conditions or pH trigger, and to the use of such compounds for conditioning a cell, tissue or organ, for example, to protect against ischaemic injury during a transplant event.

  本发明提供了在生理条件或pH触发下能够释放一氧化碳的有机化合物，以及将这种化合物用于调节细胞、组织或器官，例如，在移植事件中保护免受缺血性损伤的使用方法。
• Substituted 5- and 6-quinoxalinecarboxylic acids and their tuberculostatic activity
  作者：František Roubínek、Viktor Bydžovský、Zdeněk Buděšínský

  DOI：10.1135/cccc19840285

  日期：——

  Condensation of aliphatic and aliphatic-aromatic α-diketones, and of substituted benzils with 2,3- and 3,4-diaminobenzoic acids and with 4,5-diamino-2-hydroxybenzoic acid gave 74 5- and 6-quinoxalinecarboxylic acids, with the same or different alkyls and aryls as substituents at position 2 and 3. The compounds with different substituents at positions 2 and 3 were resolved into positional isomers. Their structures were determined by means of the dipole moments. The compounds were tested for tuberculostatic activity. Some exhibited it in vitro (LI, LVII), but failed in vivo.

  脂肪族和脂肪族-芳香族α-二酮与2,3-和3,4-二氨基苯甲酸以及4,5-二氨基-2-羟基苯甲酸的缩合反应产生了74种5-和6-喹啉羧酸，位置2和3上的取代基可以是相同的或不同的烷基和芳基。在位置2和3有不同取代基的化合物被分解成位置异构体。它们的结构是通过偶极矩确定的。这些化合物被检测其抗结核活性。一些化合物在体外（LI，LVII）表现出该活性，但在体内失败。
• Efficient Synthesis of Imidazoles from Aldehydes and 1,2-Diketones under Superheating Conditions by Using a Continuous Flow Microreactor System under Pressure
  作者：Lingjie Kong、Xiaoming Lv、Qi Lin、Xiaofeng Liu、Yaming Zhou、Yu Jia

  DOI：10.1021/op100058h

  日期：2010.7.16

  and efficient method for the synthesis of 2,4,5-trisubstituted imidazoles has been developed by using a continuous flow microreactor system under pressure; aryl-, alkyl-, and heteroaryl-substituted imidazoles were obtained in high yields within 2 min under superheating conditions.

  通过在压力下使用连续流动微反应器系统，已经开发出一种简单有效的合成2,4,5-三取代的咪唑的方法。在过热条件下，在2分钟内以高收率获得了芳基，烷基和杂芳基取代的咪唑。
• Stereoselective Chiral Recognition of Amino Alcohols with 2,2′-Dihydroxybenzil
  作者：Min-Seob Seo、Daeyoung Sun、Hyunwoo Kim

  DOI：10.1021/acs.joc.7b00600

  日期：2017.7.7

  demonstrated to be a highly diastereoselective stereodynamic receptor for the chiral recognition of amino alcohols. The receptor by forming diimine compounds with amino alcohols showed good (11:1) to excellent (>50:1) diastereoselectivity in chloroform. The existence of intramolecular hydrogen bonding with amino alcohols only in an axial conformer is demonstrated by 1H NMR and CD spectroscopy, X-ray

  已证明2,2'-二羟基苯甲酸酯是用于手性识别氨基醇的高度非对映选择性立体动力学受体。通过与氨基醇形成二亚胺化合物形成的受体在氯仿中表现出良好的（11：1）至出色的（> 50：1）非对映选择性。通过1 H NMR和CD光谱，X射线晶体学和DFT计算证明了仅在轴向构象体中与氨基醇的分子内氢键的存在。激子手性方法可与重氮基连接的2,2'-二羟基苯甲醚一起使用。
• Design, synthesis, and characterization of novel organic–inorganic hybrid polymeric materials for electroluminescence applications
  作者：Anil Kumar、Shubham Bawa、Anasuya Bandyopadhyay

  DOI：10.1039/d0nj00088d

  日期：——

  Design and syntheses of two electroluminescent metallopolymers from a novel, multidentate, redox active, and di-anionic organic building block.

  使用一种新型的多齿、氧化还原活性和二阴离子有机构建块，设计和合成了两种电致发光金属聚合物。