2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropionic acid 1-isopropoxy carbonyloxyethyl ester | 1319719-22-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropionic acid 1-isopropoxy carbonyloxyethyl ester
• 英文别名: 1-Propan-2-yloxycarbonyloxyethyl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate
• CAS: 1319719-22-6
• 化学式: C₂₃H₂₅ClO₇
• 分子量: 448.9
• InChiKey: GVRRNBZCZFHVMU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  31
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  88.1
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  非诺贝特酸 、 1-碘乙基异丙基碳酸酯 在 四甲基胍 作用下， 以 N,N-二甲基乙酰胺 为溶剂， 反应 1.08h， 以85%的产率得到2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropionic acid 1-isopropoxy carbonyloxyethyl ester
  参考文献：
  名称：

  Synthesis and Biological Evaluation of Orally Active Hypolipidemic Agents

  摘要：

  A series of novel fenofibric acid ester pro drugs 1c-1h were synthesized and evaluated with the aim of obtaining potent hypolipidemic agents. Prodrugs 1c and 1d exhibited potent hypochlolesterolemic activity, lowering the mice plasma triglyceride level up to 47% in Swiss albino mice after oral administration of 50 mg/kg/day for 8 days. Fenofibric acid ester prodrugs 1c-1h were found lipophilic like fenofibrate (1b), indicated by partition coefficients measured in octanol-buffer system at pH 7.4. On the basis of in vivo studies, prodrugs 1c and 1d emerged as potent hypolipidemic agents.

  DOI：

  10.1021/jm200704f

文献信息

• Synthesis and Biological Evaluation of Orally Active Hypolipidemic Agents
  作者：Babasaheb P. Bandgar、Rajendra J. Sarangdhar、Fruthous Khan、Jeyamurugan Mookkan、Pranesha Shetty、Gajendra Singh

  DOI：10.1021/jm200704f

  日期：2011.8.25

  A series of novel fenofibric acid ester pro drugs 1c-1h were synthesized and evaluated with the aim of obtaining potent hypolipidemic agents. Prodrugs 1c and 1d exhibited potent hypochlolesterolemic activity, lowering the mice plasma triglyceride level up to 47% in Swiss albino mice after oral administration of 50 mg/kg/day for 8 days. Fenofibric acid ester prodrugs 1c-1h were found lipophilic like fenofibrate (1b), indicated by partition coefficients measured in octanol-buffer system at pH 7.4. On the basis of in vivo studies, prodrugs 1c and 1d emerged as potent hypolipidemic agents.