Pregnanolone formate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: Pregnanolone formate
• 英文别名: [(3R,5R,8R,9S,10S,13S,14S,17S)-17-acetyl-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] formate
• 化学式: C₂₂H₃₄O₃
• 分子量: 346.51
• InChiKey: WQOSPYRSDOSGLK-XQJOZJDQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  甲酸 、 孕烷醇酮 在 4-dimethylpyridine 、 乙酸酐 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成 Pregnanolone formate
  参考文献：
  名称：

  Weaver, Charles E.; Land, Michele B.; Purdy, Robert H., Journal of Pharmacology and Experimental Therapeutics, 2000, vol. 293, # 3, p. 747 - 754

  摘要：

  DOI：

文献信息

• COMPOUNDS AND METHODS INVOLVING STEROLS
  申请人：Warsaw Orthopedic, Inc.

  公开号：US20160159848A1

  公开（公告）日：2016-06-09

  Compounds and methods of synthesizing oxysterols are provided. The compounds and methods provided allow the oxysterol to be safely produced at a high yield. The compounds and methods provided can produce the oxysterol in a stereoselective manner.

  提供了合成醇固醇类化合物和方法。提供的化合物和方法使得醇固醇能够以高产率安全地生产。提供的化合物和方法可以以立体选择性方式产生醇固醇。
• Effect of steroids on NMDA receptors depends on subunit composition
  申请人：——

  公开号：US20040204490A1

  公开（公告）日：2004-10-14

  Disclosed is a method for identifying a subunit specific modulator of the N-methyl-D-aspartate (NMDA) receptor. The method involves providing a plurality of NMDA receptors which differ in their subunit identity. The receptors are contacted with a neurotransmitter recognition site ligand in the presence and absence of a candidate modulator. Receptor activity is then assayed, with an increase or decrease in activity in at least one, but not all members of the plurality of NMDA receptors, in the presence but not the absence of a candidate modulator, being an indication that the candidate modulator is a subunit specific modulator. The subunit identity of the subset of the NMDA receptors to determine the subunit specificity of the candidate modulator. Various combinations of NMDA receptor subunits are provided.

  本文披露了一种识别N-甲基-D-天门冬氨酸（NMDA）受体亚单位特异性调节剂的方法。该方法涉及提供多个在其亚单位身份上不同的NMDA受体。在存在和不存在候选调节剂的情况下，将受体与神经递质识别位点配体接触。然后测定受体活性，存在于多个NMDA受体中至少一个，但不是全部，在候选调节剂存在但不存在时活性增加或减少，表明候选调节剂是亚单位特异性调节剂。确定NMDA受体亚单位的子集以确定候选调节剂的亚单位特异性。提供了各种NMDA受体亚单位的组合。
• Oxysterol-therapeutic agent derivative for bone healing
  申请人：Warsaw Orthopedic, Inc.

  公开号：US10294264B2

  公开（公告）日：2019-05-21

  Oxysterol-therapeutic agent derivatives or OXY133-therapeutic agent derivative compounds and methods of synthesizing the same are provided for use in promoting osteogenesis, osteoinduction and/or osteoconduction. Methods of synthesizing in a single container OXY133-therapeutic agent derivatives having high yields and improved process safety are also provided. Methods for synthesizing OXY133-therapeutic agent derivatives that are stereoselective are also provided.

  提供了用于促进成骨、骨诱导和/或骨诱导的氧基甾醇治疗剂衍生物或 OXY133 治疗剂衍生物化合物及其合成方法。还提供了在单个容器中合成 OXY133-治疗剂衍生物的方法，该方法产量高，工艺安全性更高。还提供了具有立体选择性的 OXY133 治疗剂衍生物的合成方法。
• Oxysterol-statin compounds for bone growth
  申请人：Warsaw Orthopedic, Inc.

  公开号：US10434106B2

  公开（公告）日：2019-10-08

  Oxysterol-statin compounds and methods of synthesizing the same are provided for use in promoting osteogenesis, osteoinduction andior osteoconduction. Methods of synthesizing in a single container OXY133-statin compounds having high yields and improved process safety are also provided. Methods for synthesizing OXY133-statin compounds that are stereoselective are also provided. Methods of synthesizing OXY133-statin conjugates that have low production costs are provided.

  本发明提供了用于促进成骨、骨诱导和骨诱导的氧基甾醇-他汀化合物及其合成方法。本发明还提供了在单个容器中合成 OXY133-atin化合物的方法，这些方法具有产量高、工艺安全性高的特点。还提供了具有立体选择性的 OXY133-atin化合物的合成方法。提供了生产成本低的 OXY133-atin共轭物的合成方法。
• EFFECT OF STEROIDS ON NMDA RECEPTORS DEPENDS ON SUBUNIT COMPOSITION
  申请人：TRUSTEES OF BOSTON UNIVERSITY

  公开号：EP1212618A1

  公开（公告）日：2002-06-12