4-propylamino-phenol | 53131-96-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-propylamino-phenol
• 英文别名: 4-(Propylamino)phenol
• CAS: 53131-96-7
• 化学式: C₉H₁₃NO
• 分子量: 151.208
• InChiKey: LEPIYBYPRPWIAA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  对硝基苯酚 、 丙腈 在 10% palladium on activated charcoal 、 氢气 作用下， 以 四氢呋喃 为溶剂， 20.0 ℃ 、101.33 kPa 条件下， 反应 30.0h， 以30%的产率得到4-propylamino-phenol
  参考文献：
  名称：

  使用腈作为烷基化试剂的芳香硝基化合物的一锅还原单-N-烷基化

  摘要：

  摘要 说明了在常压和环境温度下在四氢呋喃中，在 H2 和 10% Pd/C 催化剂存在下，由各种硝基芳烃和腈合成芳香仲胺的一锅法、简单、选择性和高效的方案。已经检查了该方法的范围和局限性。

  DOI：

  10.1080/00397911.2010.493627

文献信息

• N-Substituted Carbamic Acid Ester Production Method, Isocyanate Production Method Using Such N-Substituted Carbamic Acid Ester, And Composition For Transfer And Storage Of N-Substituted Carbamic Acid Ester Comprising N-Substituted Carbamic Acid Ester and Aromatic Hydroxy Compound
  申请人：Shinohata Masaaki

  公开号：US20110133121A1

  公开（公告）日：2011-06-09

  The present invention is a method for producing an N-substituted carbamic acid ester derived from an organic amine from an organic amine, a carbonic acid derivative and a hydroxy composition containing one or more types of hydroxy compounds, wherein the organic amine, the carbonic acid derivative and the hydroxy composition are reacted using a urethane production reaction vessel provided with a condenser, a gas containing the hydroxy composition, the compound having the carbonyl group derived from the carbonic acid derivative, and an ammonia formed as a by-product in the reaction, is introduced into the condenser provided in the urethane production reaction vessel, and the hydroxy composition and the compound having the carbonyl group derived from the carbonic acid derivative are condensed, and wherein a stoichiometric ratio of a hydroxy compound contained in the condensed hydroxy composition to the condensed compound having the carbonyl group derived from the carbonic acid derivative is 1 or more, and a ratio of number of carbonyl groups (—C(═O)—) contained in the compound having the carbonyl group derived from the carbonic acid derivative and number of ammonia molecules contained in the ammonia recovered as a gas from the condenser is 1 or less.

  本发明涉及一种从有机胺、碳酸衍生物和含有一种或多种羟基化合物中制得的N-取代氨基甲酸酯的制备方法，其中使用一种含有冷凝器的脲类生产反应容器反应有机胺、碳酸衍生物和羟基化合物，将含有羟基化合物的气体、来自碳酸衍生物衍生的含有羰基基团的化合物、以及在反应中形成的氨气体引入到脲类生产反应容器中的冷凝器中，使羟基化合物和含有羰基基团的化合物冷凝，其中在冷凝的羟基化合物中所含有的羟基化合物与冷凝的含有羰基基团的化合物中所含有的羰基基团的化合物的比例为1或更多，而且在从冷凝器中回收的氨气体中所含有的羰基基团（—C(═O)—）数与氨分子数的比例为1或更少。
• N-Substituted Carbamic Acid Ester Production Method, Isocyanate Production Method Using Such N-Substituted Carbamic Acid Ester, and Composition for Transfer and Storage of N-Substituted Carbamic Acid Ester Comprising N-Substituted Carbamic Acid Ester and Aromatic Hydroxy Compound
  申请人：Asahi Kasei Chemicals Corporation

  公开号：US20140194650A1

  公开（公告）日：2014-07-10

  The present invention is a method for producing an N-substituted carbamic acid ester derived from an organic amine from an organic amine, a carbonic acid derivative and a hydroxy composition containing one or more types of hydroxy compounds, wherein the organic amine, the carbonic acid derivative and the hydroxy composition are reacted using a urethane production reaction vessel provided with a condenser, a gas containing the hydroxy composition, the compound having the carbonyl group derived from the carbonic acid derivative, and an ammonia formed as a by-product in the reaction, is introduced into the condenser provided in the urethane production reaction vessel, and the hydroxy composition and the compound having the carbonyl group derived from the carbonic acid derivative are condensed, and wherein a stoichiometric ratio of a hydroxy compound contained in the condensed hydroxy composition to the condensed compound having the carbonyl group derived from the carbonic acid derivative is 1 or more, and a ratio of number of carbonyl groups (—C(═O)—) contained in the compound having the carbonyl group derived from the carbonic acid derivative and number of ammonia molecules contained in the ammonia recovered as a gas from the condenser is 1 or less.

  本发明是一种从有机胺、碳酸酯衍生物和含有一种或多种羟基化合物中制备N-取代的氨基甲酸酯的方法，其中利用一种尿素生产反应容器反应有机胺、碳酸酯衍生物和羟基化合物，该反应容器配有冷凝器，将含有羟基化合物的气体、由碳酸酯衍生物产生的含有羰基基团的化合物以及在反应中生成的氨引入到尿素生产反应容器中的冷凝器中，将羟基化合物和含有羰基基团的碳酸酯衍生物冷凝，其中在冷凝的羟基化合物中所含的羟基化合物的化学计量比与所冷凝的含有羰基基团的化合物的化学计量比为1或更多，而且所含有羰基基团的化合物中所含的羰基基团（-C(═O)-）的数量与从冷凝器中回收的氨分子数量的比率为1或更小。
• NOVEL s-TRIAZOLE(1,5-a)PYRIMIDINE DERIVATIVES
  申请人：MOCHIDA PHARMACEUTICAL CO., LTD.

  公开号：EP0101517A1

  公开（公告）日：1984-02-29

  Novel s-triazole[1,5-a]pyrimidine derivatives represented by the general formula (I): wherein R, and R2 may be the same or different and each represents a straight or branched alkyl group containing 1 to 6 carbon atoms, a phenyl group or a hydrogen atom, R3 represents a straight or branched alkyl group containing 1 to 6 carbon atoms or a hydrogen atom, R4 represents a straight or branched alkyl group containing 1 to 6 carbon atoms, a phenyl group or a substituted phenyl group, and R5 represents a hydrogen atom or R5 and R, together form a -(CH2)- group. The compounds have vasodilating, hypotensive and blood platelet agglutination-preventing effects, and are useful for treating diseases of circulatory organs.

  通式(I)代表的新型 s-三唑[1,5-a]嘧啶衍生物： 其中 R 和 R2 可以相同或不同，各自代表含有 1 至 6 个碳原子的直链或支链烷基、苯基或氢原子；R3 代表含有 1 至 6 个碳原子的直链或支链烷基或氢原子；R4 代表含有 1 至 6 个碳原子的直链或支链烷基、苯基或取代苯基；R5 代表氢原子或 R5 和 R 共同形成-(CH2)-基团。这些化合物具有扩张血管、降血压和防止血小板凝集的作用，可用于治疗循环器官疾病。
• Process for preparing N-alkylaminophenols
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0218350A1

  公开（公告）日：1987-04-15

  A process for preparing an N-alyklaminophenol represented by the formula (III): wherein R, represents a hydrogen atom or an alkyl group having from 1 to 6 carbon atoms; and R2 represents an alkyl group having from 1 to 6 carbon atoms, which comprises reacting an aminophenol represented by the formula (I): wherein R1 is as defined above, with an alkyl halide represented by the formula (II): wherein R2 is as defined above; and X represents a halogen atom, at 80°-120 °C at 3-30 kg/cm2G pressure in an autoclave in the presence of water under heat and pressure, using ammonia as an acid scavenger, 1-2 mols of alkyl halide are used per mol of alkyl group and 1-3 mols ammonia per mol compound (I). The ammonia is preferably introduced continuously while the pH is 4-10, and with 0.05-4 parts by wt. water per wt. of aminophenol.

  一种制备由式(III)代表的N-烯丙基氨基苯酚的工艺： 其中 R 代表氢原子或具有 1 至 6 个碳原子的烷基；R2 代表具有 1 至 6 个碳原子的烷基，该工艺包括使式（I）代表的氨基苯酚与式（II）代表的烷基卤化物反应： 其中 R1 如上定义，与式 (II) 所代表的烷基卤化物反应： 其中 R2 如上所定义；X 代表卤素原子，在 80°-120 °C，3-30 kg/cm2G 压力下，在有水存在的高压釜中，在加热和加压条件下，使用氨作为酸清除剂、 每摩尔烷基使用 1-2 摩尔烷基卤化物，每摩尔化合物（I）使用 1-3 摩尔氨。 氨水最好在 pH 值为 4-10 时连续加入，每重量份氨基苯酚加入 0.05-4 重量份的水。
• Utilisation de phényléthanolamines pour la préparation de médicaments agissant sur les troubles gastro-intestinaux
  申请人：ELF SANOFI

  公开号：EP0255415A2

  公开（公告）日：1988-02-03

  Utilisation d'analogues de phényléthanolamine, éventuellement substituée sur le groupe phényle par un atome d'halogène ou par un groupe alkyle ou trifluorométhyle et substituée sur le groupe amino par un groupe phénylalkyle ou phénoxyalkyle éventuellement substitué sur le noyau benzène comme principes actifs pour la préparation de médicaments pour la prophylaxie ou le traitement de troubles gastro-­intestinaux associés à une contraction du muscle lisse.

  苯乙醇胺类似物（苯基上可选择被卤原子或烷基或三氟甲基取代，氨基上可选择被苯环上的苯烷基或苯氧基烷基取代）作为活性成分，用于制备预防或治疗与平滑肌收缩有关的胃肠道疾病的药物。