(Z)-butanal (α)-chloro-oxime

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氯化物
• 英文名称: (Z)-butanal (α)-chloro-oxime
• 英文别名: (Z)-N-hydroxybutyrimidoyl chloride；1-chloro-n-butyraldehyde oxime；(1Z)-N-hydroxybutanimidoyl chloride
• 化学式: C₄H₈ClNO
• 分子量: 121.567
• InChiKey: UQBGWOJBYNZPPZ-XQRVVYSFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  32.6
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (Z)-butanal (α)-chloro-oxime 在 氯 、 magnesium methanolate 作用下， 以 甲醇 为溶剂， 生成 1-methoxy-n-butyraldehyde oxime
  参考文献：
  名称：

  Process for the preparation of N-hydroxy organo imidate compounds

  摘要：

  这项发明涉及一种通过将肟化合物与卤化剂反应，并将所得的1-卤代肟化合物与醇的碱金属或碱土金属盐反应制备N-羟基有机亚胺化合物的方法。

  公开号：

  US04614813A1

文献信息

• Synthesis and biological evaluation of fluoro-substituted spiro-isoxazolines as potential anti-viral and anti-cancer agents
  作者：Prasanta Das、Sarah Boone、Dipanwita Mitra、Lindsay Turner、Ritesh Tandon、Drazen Raucher、Ashton T. Hamme

  DOI：10.1039/d0ra06148d

  日期：——

  Electrophilic fluorine-mediated dearomative spirocyclization has been developed to synthesize a range of fluoro-substituted spiro-isoxazoline ethers and lactones. The in vitro biological assays of synthesized compounds were probed for anti-viral activity against human cytomegalovirus (HCMV) and cytotoxicity against glioblastomas (GBM6) and triple negative breast cancer (MDA MB 231). Interestingly,

  亲电氟介导的脱芳香螺环化已被开发用于合成一系列氟取代的螺异恶唑啉醚和内酯。对合成化合物进行体外生物学测定，探讨其对人巨细胞病毒 (HCMV) 的抗病毒活性以及对胶质母细胞瘤 (GBM6) 和三阴性乳腺癌 (MDA MB 231) 的细胞毒性。有趣的是，化合物4d和4n显示出显着的抗HCMV活性（IC 50 ∼ 10 μM），而4l和5f显示出最高的细胞毒性，IC 50 = 36 〜 80 μM。合成功效和生物学相关性为进一步开发氟螺螺异恶唑啉作为新型抗病毒和抗癌药物提供了机会。
• A Convenient Synthesis of 4-Alkyl-5-aminoisoxazoles
  作者：Matthew P. Bourbeau、James T. Rider

  DOI：10.1021/ol061260+

  日期：2006.8.1

  A series of 4-alkyl-5-aminoisoxazoles have been synthesized in high yield by nucleophilic addition of lithiated alkyl nitriles to (alpha)-chlorooximes. The scope and limitations of this reaction were examined by varying the nature of the nitrile and chloride oxime.
• Analysis of Intact Glucosinolates by MALDI-TOF Mass Spectrometry
  作者：Catherine H. Botting、Nicola E. Davidson、D. Wynne Griffiths、Richard N. Bennett、Nigel P. Botting

  DOI：10.1021/jf011129a

  日期：2002.2.1

  Glucosinolates are naturally occurring plant compounds that may be important in the dietary prevention of cancer. This study shows that they can be detected in their intact form by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) with a high degree of sensitivity. The methodology was used to characterize a number of individual glucosinolates either produced by synthetic chemistry or isolated from plants. The method was used for crude plant extracts to rapidly examine the glucosinolate profile of the plant. The results for a range of plant extracts showed good agreement with previous LC-MS analysis of the desulfoglucosinolates from the same samples.
• REMBARZ, G.;FISCHER, E.;JAKUBOWSKI, S.;EVERS, R., WISS. Z. WILCHELM-PIECK-UNIV. ROSTOCK. NATURWISS. R., 1982, 31, N 9, 11-1+
  作者：REMBARZ, G.、FISCHER, E.、JAKUBOWSKI, S.、EVERS, R.

  DOI：——

  日期：——