erythrosine B | 548-25-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: erythrosine B
• 英文别名: 2',4',5',7'-tetraiodofluorescein；2,4,5,7-tetraiodofluorescein；erythrosin extra bluish；FD and C red no. 3；Erythrosin B；Erythrosin(E)；2-(3-hydroxy-2,4,5,7-tetraiodo-6-oxoxanthen-9-yl)benzoic acid
• CAS: 548-25-4
• 化学式: C₂₀H₈I₄O₅
• mdl: MFCD00066642
• 分子量: 835.899
• InChiKey: LAINPTZBIXYTIZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  29
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  83.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  erythrosine B 、 ferroin 在 Britton-Robinson buffer 作用下， 以 水 为溶剂， 生成 [Fe(phenanthroline)3(erythrosine(-2H))]
  参考文献：
  名称：

  Resonance Rayleigh scattering, second-order scattering and frequency doubling scattering spectra for studying the interaction of erythrosine with and its analytical application

  摘要：

  In a weak alkaline Britton-Robinson buffer medium, erythrosine (Ery) can react with Fe(phen)(3)(2+) to form 1:1 ion-association complex, which will cause not only the changes of the absorption spectra, but also the remarkable enhancement of resonance Rayleigh scattering (RRS), second-order scattering (SOS) and frequency doubling scattering (FDS) spectra, and the appearance of new spectra of RRS. SOS and FDS. The maximum RRS, SOS and FDS wavelengths (lambda(ex)/lambda(em)) of the ion-association complex are located at 358/358 nm, 290/580 nm and 7801390 nm, respectively. The increments of scattering intensities (Delta I) are directly proportional to the concentration of Ery in a certain range. The detection limits for Ery are 0.028 mu g mL(-1) for RRS method, 0.068 mu g mL(-1) for SOS method and 0.11 mu g mL(-1) for FDS method, respectively. Among them, the RRS method has the highest sensitivity. Based on the above researches, a new highly sensitive and simple method for the determination of Ery has been developed. In this work, the spectral characteristics of absorption. RRS, SOS and FDS spectra, the optimum conditions of the reaction and influencing factors for the RRS. SOS and FDS intensities were investigated. In addition, the reaction mechanism was discussed. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2011.03.046
• 作为产物：
  描述：

  二氢荧光黄二乙酸盐 在 4-二甲氨基吡啶 、 sodium hydroxide 、 氨 、 碘 、 N,N'-二环己基碳二亚胺 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 4.5h， 生成 erythrosine B
  参考文献：
  名称：

  醇和胺与二乙酰基二氢荧光素（DADF）的反应：通过氨和碘蒸气在TLC板上转化为赤藓氨酸衍生物

  摘要：

  癸基秋水仙碱（2）和秋水仙碱（3）与二乙酰基二氢荧光素（1，DADF）反应，得到相应的酰胺和酯衍生物，在氨和碘蒸气暴露于TLC板上后转化为红色颜料。用可待因，奎宁和甲斯卡林的DADF衍生物也观察到该反应高度敏感。由氨-碘处理形成的秋水仙碱的DADF-酯（6）产生的红色颜料是相应的赤藓红酸酯衍生物。从这些研究中得出的DADF可以用作检测粗混合物中的醇和胺以及进行染料标记的有用试剂。

  DOI：

  10.1002/hlca.19840670136
• 作为试剂：
  描述：

  乙酰丙酮 、 安妥 在 erythrosine B 、 氧气 作用下， 以 乙腈 为溶剂， 反应 16.0h， 以51%的产率得到1-(4-methyl-2-(naphthalen-1-ylamino)thiazol-5-yl)ethanone
  参考文献：
  名称：

  硫脲和1,3-二羰基化合物的可见光介导偶联：迈向无离去合成氨基噻唑

  摘要：

  已经开发了由各种1,3-二羰基和硫脲合成的不带离去基团的氨基噻唑的方法。该反应被有机染料四碘荧光素光催化。在绿色LED照射下，硫脲原位产生硫自由基，然后添加到烯醇互变异构体中，形成氨基噻唑骨架。这种新颖的策略提供了卓越的原子经济性，从而可以替代传统的离去基团方案，从而提供了更绿色的选择。

  DOI：

  10.1002/adsc.201701565

文献信息

• Assessment of encapsulated dyes’ distribution in silica nanoparticles and their ability to release useful singlet oxygen
  作者：Vladimir Kabanov、David J. Press、Racheal P. S. Huynh、George K. H. Shimizu、Belinda Heyne

  DOI：10.1039/c8cc03413c

  日期：——

  Working with silica nanoparticle encapsulated BODIPY and xanthene photosensitizers, we have determined that singlet oxygen spends up to 78% of its lifetime inside the nanocarriers.

  通过与被二氧化硅纳米粒子包裹的BODIPY和占吨染料光敏剂合作，我们已经确定单线态氧在其中度过了高达78%的生命周期。

• COLORING AGENTS AND METHODS OF USE THEREOF
  申请人：Living Proof, Inc.

  公开号：US20160106648A1

  公开（公告）日：2016-04-21

  Dyes, compositions comprising dyes and methods for using the same are provided.

  染料、包含染料的组合物以及使用这些染料的方法。
• AMYLOID-BINDING COMPOUNDS AND METHODS OF USE THEREOF
  申请人：Vanderbilt University

  公开号：US20210011008A1

  公开（公告）日：2021-01-14

  A method of screening for amyloid-binding compounds, amyloid-binding compounds, and a method of detecting amyloid-β (Abeta) plaques in a subject are disclosed. The method of screening for amyloid-binding compounds includes combining amyloid, a dye, and at least one test compound to form a sample solution; equilibrating the sample solution; measuring a fluorescence signal of the sample solution; and comparing the measured fluorescence signal of the sample to a control; wherein attenuation of the fluorescence signal, as compared to the control, indicates that one or more of the test compounds bind amyloid. The amyloid-binding compound includes a compound detected by the screening method. The method of detecting amyloid-β (Abeta) plaques in a subject includes administering one or more of the amyloid-binding compounds to the subject, and detecting the compound within the subject.

  揭示了一种筛选淀粉样结合化合物、淀粉样结合化合物的方法，以及检测受试者中淀粉-β（Abeta）斑块的方法。筛选淀粉样结合化合物的方法包括将淀粉、染料和至少一种试剂化合物组合以形成样品溶液；平衡样品溶液；测量样品溶液的荧光信号；并将所测得的样品的荧光信号与控制进行比较；其中，与控制相比减弱的荧光信号表明一个或多个试剂化合物与淀粉结合。淀粉样结合化合物包括通过筛选方法检测到的化合物。在受试者中检测淀粉-β（Abeta）斑块的方法包括向受试者施用一个或多个淀粉样结合化合物，并在受试者内检测化合物。
• CONFORMABLE SOLVENT-BASED BANDAGE AND COATING MATERIAL
  申请人：Salamone Beal Ann

  公开号：US20070041935A1

  公开（公告）日：2007-02-22

  Liquid hemostatic coating materials comprise a cyanoacrylate monomer and a solvent system comprising a volatile, non-reactive liquid that is non-stinging and non-irritating to a user. The material forms a coating or bandage in the form of a film that when applied and adhered to a surface or to the skin of a user inhibits the application surface from adhering to another surface.

  液态止血涂层材料包括氰基丙烯酸酯单体和溶剂体系，其中溶剂体系包括一种挥发性、非反应性液体，对用户无刺激性和无刺激性。该材料形成一种涂层或绷带形式的薄膜，当应用并粘附到表面或用户的皮肤上时，抑制应用表面与另一表面粘附。
• Leave-in color conditioner
  申请人：Pollack George

  公开号：US20050198746A1

  公开（公告）日：2005-09-15

  The invention is directed to novel hair dye compositions, novel leave-in conditioners, and novel leave-in conditioners with a hair coloring effect. Hair dye compositions, leave-in conditioners, and leave-in conditioners with hair coloring effect may include a styrene/vinylpyrrolidone copolymer emulsion.

  本发明涉及新型染发剂组合物、新型留香护发素以及具有染发效果的新型留香护发素。染发剂组合物、留香护发素和具有染发效果的留香护发素可能包括苯乙烯/吡咯烷酮共聚物乳液。