4-((benzo[d]thiazol-2-ylthio)methyl)-6-hydroxy-5-methyl-2H-chromen-2-one | 1449385-60-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 4-((benzo[d]thiazol-2-ylthio)methyl)-6-hydroxy-5-methyl-2H-chromen-2-one
• 英文别名: 4-(1,3-Benzothiazol-2-ylsulfanylmethyl)-7-hydroxy-5-methylchromen-2-one；4-(1,3-benzothiazol-2-ylsulfanylmethyl)-7-hydroxy-5-methylchromen-2-one
• CAS: 1449385-60-7
• 化学式: C₁₈H₁₃NO₃S₂
• 分子量: 355.438
• InChiKey: MERKQUOJHXKOEY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  113
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  4-(chloromethyl)-7-hydroxy-5-methyl-2H-chromen-2-one 、 2-巯基苯并噻唑 在 sodium hydroxide 作用下， 以 N,N-二甲基甲酰胺-d7 、 水 为溶剂， 以75%的产率得到4-((benzo[d]thiazol-2-ylthio)methyl)-6-hydroxy-5-methyl-2H-chromen-2-one
  参考文献：
  名称：

  Efficient synthesis and antiproliferative activity of novel thioether-substituted flavonoids

  摘要：

  As widely occurring natural products, flavonoids are an important source for drug discovery, due to their structural diversity and broad-spectrum biological activity. In this work, a library of novel, thioether-substituted flavonoids with diverse heterocyclic groups was synthesized via a microwave-assisted procedure with the advantages of good yields, short times, mild conditions and ready isolation of the products. Their antiproliferative activities were evaluated against six cancer cell lines, HCCLM-7, Hela, MDA-MB-435S, SW-480, Hep-2, and MCF-7 by the MU-based assay. Compared with the positive control 5-fluorouracil, three compounds, 6a, 6b and 6j were successfully identified as the most promising candidates, due to their higher potency and broad-spectrum bioactivity with IC50 values in the range of 0.43 mu M-6.7 mu M. (C) 2013 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2013.05.037

文献信息

• Efficient synthesis and antiproliferative activity of novel thioether-substituted flavonoids
  作者：Wei Huang、Qiong Chen、Wen-Chao Yang、Guang-Fu Yang

  DOI：10.1016/j.ejmech.2013.05.037

  日期：2013.8

  As widely occurring natural products, flavonoids are an important source for drug discovery, due to their structural diversity and broad-spectrum biological activity. In this work, a library of novel, thioether-substituted flavonoids with diverse heterocyclic groups was synthesized via a microwave-assisted procedure with the advantages of good yields, short times, mild conditions and ready isolation of the products. Their antiproliferative activities were evaluated against six cancer cell lines, HCCLM-7, Hela, MDA-MB-435S, SW-480, Hep-2, and MCF-7 by the MU-based assay. Compared with the positive control 5-fluorouracil, three compounds, 6a, 6b and 6j were successfully identified as the most promising candidates, due to their higher potency and broad-spectrum bioactivity with IC50 values in the range of 0.43 mu M-6.7 mu M. (C) 2013 Elsevier Masson SAS. All rights reserved.