4-二乙基氨基苯酚 | 17609-82-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 4-二乙基氨基苯酚
• 英文名称: 4-(diethylamino)phenol
• 英文别名: 4-Diethylaminophenol
• CAS: 17609-82-4
• 化学式: C₁₀H₁₅NO
• mdl: MFCD14538616
• 分子量: 165.235
• InChiKey: INDIALLCZKIHFF-UHFFFAOYSA-N

物化性质

• 沸点：
  290.0±23.0 °C(Predicted)
• 密度：
  1.040±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2922299090

反应信息

• 作为反应物：
  描述：

  4-二乙基氨基苯酚 在 溴 作用下， 以 水 为溶剂， 生成 p-Diaethylaminophenoxy-Radikal
  参考文献：
  名称：

  An Investigation of Electron Transfer Reactions between Aromatic and Quinoid Systems

  摘要：

  AbstractA classical organic redox reaction is the conversion of an aromatic compound from its reduced form R to a semioxidized state S, and further to a totally oxidized (quinoid) species T. Complex redox systems are present in a reaction of quinoid and aromatic forms derived from different parent compounds. In this case, the exchange of one or two electrons in one step between T and R can be distinguished experimentally. These reactions were investigated in a stopped‐flow apparatus with optical detection. In the system N,N,N′,N′‐tetramethyl‐para‐phenylene‐diamine/N,N‐dimethyl‐para‐phenylene‐diamine the rate constants for all elementary reactions have been determined. Protonated, and unprotonated R were found to be reactive. In this system, as well as the others considered, no direct transfer of two electrons between T1 and R2 takes place. The essential steps of the mechanism have to be seen in a mixed symproportionation yielding S1 and S2, and a subsequent fast oxidation of S2 by surplus starting material T1. As a generalization, a tangent criterion has been derived to distinguish between one‐ and two‐electron steps in such mixed redox systems.

  DOI：

  10.1002/bbpc.198800110
• 作为产物：
  描述：

  4-硝基苯乙醚 生成 4-二乙基氨基苯酚
  参考文献：
  名称：

  Horn, 1937, vol. 249, p. 82

  摘要：

  DOI：

文献信息

• QUENCHER
  申请人：Wako Pure Chemical Industries, Ltd.

  公开号：US20170342031A1

  公开（公告）日：2017-11-30

  A quencher is disclosed having a compound represented by the following general formula (1): wherein R 5 each independently represent a halogen atom, an alkyl group, an alkoxy group, an alkylthio group, an amino group having a substituent or not having a substituent, a hydroxy group, an aryl group, an aryloxy group, or an arylalkyl group; R 6 represents a group having a polymerizable unsaturated group, a hydroxy group, or the like; Y 1 represents an oxygen atom, or the like; An − represents an anion; Ar 1 represents a specific ring structure; * and ** represent binding positions; Ar 2 represents a benzene ring, a naphthalene ring, or an anthracene ring; n 1 represents a specific integer; and the following structure (1-10) in the general formula (1) is an asymmetric structure; (wherein R 5 , Y 1 , Ar 1 , Ar 2 , n 1 , * and ** are the same as described above.).

  一种淬灭剂被公开，该淬灭剂具有以下一般公式(1)表示的化合物： 其中R5各自独立代表一个卤素原子、一个烷基团、一个烷氧基团、一个烷硫基团、一个带有或不带有取代基的氨基团、一个羟基、一个芳基团、一个芳氧基团或一个芳烷基团；R6代表一个具有可聚合不饱和基团、一个羟基或类似基团的集团；Y1代表一个氧原子或类似；An代表一个阴离子；Ar1代表一个特定的环结构；*和**代表结合位置；Ar2代表一个苯环、一个萘环或一个蒽环；n1代表一个特定的整数； 并且一般公式(1)中的以下结构(1-10)是一个不对称结构； (其中R5、Y1、Ar1、Ar2、n1、*和**与上述描述相同)。
• Highly Active Ni Nanoparticles on N‐doped Mesoporous Carbon with Tunable Selectivity for the One‐Pot Transfer Hydroalkylation of Nitroarenes with EtOH in the Absence of H ₂
  作者：Yuewen Tao、Yunqing Nie、Haitao Hu、Ke Wang、Yi Chen、Renfeng Nie、Jianshe Wang、Tianliang Lu、Yongsheng Zhang、Chunbao Charles Xu

  DOI：10.1002/cctc.202100925

  日期：2021.10.7

  Ni/NC-650 catalyst achieved complete conversion of various nitroarenes, yielding imines, secondary amines, or tertiary amines selectively by simply controlling the reaction temperature at 180, 200 and 240 °C, respectively. The one-pot hydrogen-free process with non-noble metal catalysts, as demonstrated in this work, shows great promise for selective conversion of nitroarenes with ethanol to various anilines

  将硝基芳烃以经济高效且环保的方式转化为增值产品是可取的，但仍具有挑战性。在这项工作中，通过新型离子交换热解策略合成了负载在 N 掺杂介孔碳 (Ni/NC-x) 上的高度分散的 Ni 纳米粒子 (NPs) 。研究了它们在没有 H 2 的情况下用 EtOH 对硝基苯 (NB) 进行一锅转移加氢烷基化反应的催化性能. 有趣的是，通过改变热解温度来调节 Ni NPs 的形态和电子状态，可以很容易地控制催化性能。发现 Ni/NC-650 实现了 100% 的硝基苯转化率和约 100% 的硝基苯转化率。N,N-二乙基苯胺在 240 °C 下 5 小时的选择性为 90 %，比均相催化剂或通过浸渍制备的负载型 Ni 催化剂（Ni/NC-650-IM、Ni/SiO 2）的活性更高）。这可以归因于催化剂具有更高的分散性和更好的还原性以及更丰富的表面碱性。更有趣的是，Ni/NC-650催化剂通过简单地将反应温度
• Polyfunctional molecules in processes of aromatic nucleophilic substitution 3. Pentaf luoropyridines as scaffolds for synthesis of liquid-phase combinatorial libraries based on S N Ar processes
  作者：V. V. Litvak、I. Ya. Mainagashev、O. G. Bukhanets

  DOI：10.1007/s11172-007-0148-3

  日期：2007.5

  (SNAr) for the synthesis of liquid-phase combinatorial libraries was studied. The real and “virtual” combinatorial libraries of diaryl ethers were synthesized by the reactions of pentafluoropyridine with phenol and its derivatives. Some criteria for the estimation of the quality of the libraries were formulated. A rational methodology for the preparation of representative combinatorial mixtures on the

  研究了在合成液相组合库的芳香亲核取代 (SNAr) 过程中使用多氟化吡啶作为多重修饰分子（即支架）的可能性。二芳基醚的真实和“虚拟”组合库是通过五氟吡啶与苯酚及其衍生物的反应合成的。制定了一些评估文库质量的标准。提出了一种基于多氟化芳烃中 SNAr 类型工艺制备代表性组合混合物的合理方法。该文库可用于转移酶功能的低分子量调节剂的高效生物筛选。
• [EN] MODULATORS OF REV-ERB<br/>[FR] MODULATEURS DE REV-ERB
  申请人：SCRIPPS RESEARCH INST

  公开号：WO2015103527A1

  公开（公告）日：2015-07-09

  The subject matter herein concerns the identification and development of potent synthetic REV-ERB ligands, such as in vivo agonists and antagonists. These compounds allow for characterization of the effects of modulation of this receptor in vivo specifically on circadian behavior and metabolism, and have suitable characteristics for development of medicinal compounds useful for treatment of malconditions such as diabetes, obesity, atherosclerosis, dyslipidemia, a circadian rhythm disorder, coronary artery disease, bipolar disorder, depression, cancer, a sleep disorder, an anxiety disorder, an addiction disorder, a bone-related disorder such osteoporosis, a skeletal muscle disease, e.g., with compromised exercise capacity, or an autoimmune disorder such as psoriasis, multiple sclerosis, inflammatory bowel disease, and others.

  本文涉及识别和开发强效合成REV-ERB配体，例如体内激动剂和拮抗剂。这些化合物可用于特定在体内对昼夜节律行为和新陈代谢的调节效果进行表征，并具有适合开发用于治疗糖尿病、肥胖症、动脉粥样硬化、血脂异常、昼夜节律紊乱、冠状动脉疾病、躁郁症、抑郁症、癌症、睡眠障碍、焦虑障碍、成瘾障碍、骨相关疾病如骨质疏松症、骨骼肌肉疾病（例如，运动能力受损）、自身免疫性疾病如牛皮癣、多发性硬化、炎症性肠病等疾病的药用化合物的特性。
• Electrochemical fluorination of aminoalkyl ethers
  作者：G.G.I. Moore、J.C. Hansen、T.M. Barrett、J.E. Waddell、K.M. Jewell、T.A. Kestner、R.M. Payfer

  DOI：10.1016/s0022-1139(00)80506-0

  日期：1986.6

  trialkylamines in liquid HF takes place readily in good yields, whereas dialkyl ethers give low yields. The latter fluorinated ethers are of interest for their low temperature properties. Our goal in this work was to prepare fluorinated aminoalkyl ether fluids which might combine the favorable yields of amines and properties of ethers. Several dialkylamine and alkylene units were combined in a variety of diamino

  已知在液体HF中三烷基胺的电化学氟化容易以良好的产率发生，而二烷基醚的产率很低。后者的氟化醚因其低温性能而受到关注。我们在这项工作中的目标是制备氟化的氨基烷基醚流体，该流体可以结合胺的良好收率和醚的性能。将几种二烷基胺和亚烷基单元结合在各种二氨基单醚，二氨基二醚和单氨基单醚中。在第一类材料中，电化学氟化产率高达50％。描述了这些新流体的结构-屈服关系和性质。