2-羟基硫代苯甲酰苯胺 | 7133-92-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 中文名称: 2-羟基硫代苯甲酰苯胺
• 英文名称: 2-hydroxythiobenzanilide
• 英文别名: 2-hydroxy-N-phenylbenzenecarbothioamide
• CAS: 7133-92-8
• 化学式: C₁₃H₁₁NOS
• 分子量: 229.302
• InChiKey: KMFUBTXFEXHGRS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  64.4
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-羟基硫代苯甲酰苯胺 在 硫酸 、 mercury(II) diacetate 、 乙酸酐 作用下， 以 溶剂黄146 为溶剂， 生成 2,3-diphenyl-2H-1,3-benzoxazin-4(3H)-one
  参考文献：
  名称：

  Leistner; Sachse; Preussler, Pharmazie, 1977, vol. 32, # 6, p. 325 - 328

  摘要：

  DOI：
• 作为产物：
  描述：

  水杨酰苯胺 在 劳森试剂 作用下， 生成 2-羟基硫代苯甲酰苯胺
  参考文献：
  名称：

  Studies on organophosphorus compounds XXI. the dimer of p-methoxyphenylthionophosphine sulfide as thiation reagent. a new route to thiocarboxamides

  摘要：

  AbstractThe thiation properties of the dimer of p‐methoxyphenylthionophosphine sulfide, 1, has been investigated by performing reactions with a representative series of aliphatic and aromatic primary, secondary, and tertiary carboxamides in the temperature range 80‐100 °C using HMPA as solvent. This new method seems to be superior to all others as in most cases quantitative yields are found. Salicylanilide, when reacted with 1, in HMPA, yields salicylthioanilide and a new type of phosphorus heterocycle, 3, whose structure has been determined by NMR‐and X‐ray analyses. 13C NMR data are tabulated for a series of thioamide carbons.

  DOI：

  10.1002/bscb.19780870311

文献信息

• One-Pot Syntheses of Methyl<i>p</i>- and<i>o</i>-Hydroxydithiobenzoates from Phenol Ethers
  作者：R. Karl Dieter、Ananda G. Lugade

  DOI：10.1055/s-1988-27549

  日期：——

  Methyl p- and o-hydroxydithiobenzoates were prepared regiospecifically in a one-pot procedure from phenol methyl- and methoxymethyl, ethers, respectively. The p-hydroxy compounds were prepared by treatment of the methyl ethers with carbon disulfide, methyl iodide, and aluminum chloride. The second procedure involves ortho-metallation, carbon disulfide dithiocarboxylation, sulfur alkylation with methyl iodide, and in situ phenol deprotection with aluminum chloride/methyl iodide.

  对羟基二硫代苯甲酸甲酯的p型和o型异构体分别通过一种一步法反应从苯酚的甲基醚和甲氧基甲基醚中具有选择性地制备得到。p型对羟基化合物是通过甲基醚与二硫化碳、碘甲烷和氯化铝的处理来制备的。第二种方法包括邻位金属化、二硫化碳二硫代羧酸化、硫的烷基化与碘甲烷以及原位苯酚的去保护与氯化铝/碘甲烷反应。
• Cellulose-reinforced poly(ethylene-<i>co</i>-vinyl acetate)-supported Ag nanoparticles with excellent catalytic properties: synthesis of thioamides using the Willgerodt–Kindler reaction
  作者：Anoop Singh、Sanjeev Saini、Narinder Singh、Navneet Kaur、Doo Ok Jang

  DOI：10.1039/d1ra09225a

  日期：——

  Fourier-transform infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray, and powder X-ray diffraction. Thereafter, the obtained hybrid was used as a catalyst for the Willgerodt–Kindler reaction of aromatic aldehydes, amines, and S8 to synthesize thioamides with excellent yields. The developed catalytic system exhibited high stability and recyclability. Moreover, the mechanical properties

  纤维素是一种生物衍生聚合物，广泛用于食品包装、染料去除、涂料和固载催化。多相催化剂在环境修复中起着至关重要的作用。在此背景下，对绿色和高性价比催化剂的需求迅速增加。本研究从稻草中提取纤维素，建立了一种高活性的固载催化模型。首先，纤维素与聚（乙烯-co-醋酸乙烯酯）（PEVA），然后将Ag纳米颗粒（AgNPs）插入纤维素-PEVA复合材料中。该过程涉及在硼氢化钠存在下还原 AgNPs。使用傅里叶变换红外光谱、扫描电子显微镜、能量色散 X 射线和粉末 X 射线衍射对制备的杂化催化剂进行了表征。此后，获得的杂化物被用作芳族醛、胺和 S 8的 Willgerodt-Kindler 反应的催化剂以优异的收率合成硫代酰胺。开发的催化体系表现出高稳定性和可回收性。此外，使用拉伸强度和冲击试验评估了混合催化剂的机械性能。还进行了数字图像的 RGB 分析以研究催化剂的主要成分。
• Intraruminal drug delivery device
  申请人：COOPERS ANIMAL HEALTH LIMITED

  公开号：EP0333311A1

  公开（公告）日：1989-09-20

  An intraruminal device for administering an active agent in the rumen of an animal, comprises a metal weight (8) which gives the device sufficient density to be retained in the rumen which is made from compacted unsintered metal. The metal weight may be cylindrical and constructed of one (8, 20, 37 or 44) or several (31,32) pieces of compacted unsintered metal, of a tubular or annular (21,69) nature or incorporated as a discrete mass (66) within a drug matrix (67). When the weight is in an exposed position of the device (e.g. Fig.4), it is preferably enclosed with a material (38) that prevents damage to the weight from rough handling.

  一种用于在动物瘤胃中施用活性剂的瘤胃内装置，包括一个金属重块（8），它使装置具有足够的密度，可保留在瘤胃中，金属重块由压实的未烧结金属制成。金属砝码可以是圆柱形的，由一块（8、20、37 或 44）或几块（31、32）压实的未烧结金属组成，具有管状或环状（21、69）的性质，或作为一个离散的块状物（66）包含在药物基质（67）中。当砝码处于设备的外露位置时（如图 4），最好用材料（38）将其封闭，以防止砝码因粗暴操作而损坏。
• Dispensing devices
  申请人：COOPERS ANIMAL HEALTH LIMITED

  公开号：EP0398663A1

  公开（公告）日：1990-11-22

  An intraruminal device for administering an active agent into the rumen of an animal, comprising a chamber (3) enclosing the active material between a closure (2) and propulsion means (a piston) (8), one of the closure and propulsion means has one or more apertures for expulsion of the active material. The active material is conveniently expelled from the device by means of a piston biased against it by the tension of the spring. The tension spring may be constructed of materials that are environmentally preferred to metal springs and in addition hold the device together.

  一种将活性剂注入动物瘤胃的瘤胃内装置，包括一个腔室（3），将活性物质封闭在封闭装置（2）和推进装置（活塞）（8）之间，其中一个封闭装置和推进装置有一个或多个孔，用于排出活性物质。通过活塞在弹簧拉力的作用下将活性材料排出装置，非常方便。拉力弹簧可由比金属弹簧更环保的材料制成，此外还可将装置固定在一起。
• Antibacterial agents and compositions, methods and systems employing same
  申请人：——

  公开号：US20020068014A1

  公开（公告）日：2002-06-06

  The present invention relates to antibacterial agents, more particularly salicylanilide substituted compositions, preferably monosubstituted salicylanilide compositions, most preferably monohalogenated salicylanilide compositions, useful in antibacterial compositions, bacteria-reducing systems, antibacterial products and bacteria-reducing methods.

  本发明涉及抗菌剂，尤其是水杨酰苯胺取代的组合物，最好是单取代水杨酰苯胺组合物，最优选的是单卤代水杨酰苯胺组合物，可用于抗菌组合物、细菌减少系统、抗菌产品和细菌减少方法。