2-(3-硝基苯基)-4,5-二氢-1,3-噻唑 | 96159-88-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-(3-硝基苯基)-4,5-二氢-1,3-噻唑
• 英文名称: 2-(3-nitrophenyl)-4,5-dihydro-1,3-thiazole
• 英文别名: 2-(3-nitrophenyl)-4,5-dihydrothiazole；2-(3-nitrophenyl)thiazoline；2-(3-nitrophenyl)-4,5-dihydro[1,3]thiazole；2-(3-nitro-phenyl)-4,5-dihydro-thiazole；2-(3-Nitro-phenyl)-4,5-dihydro-thiazol
• CAS: 96159-88-5
• 化学式: C₉H₈N₂O₂S
• 分子量: 208.241
• InChiKey: ODDGNCOLWASLCW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  83.5
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-苯基-4,5-二氢-1,3-噻唑 生成 2-(3-硝基苯基)-4,5-二氢-1,3-噻唑
  参考文献：
  名称：

  Aminophenyl Thiazolines and Thiazines

  摘要：

  DOI：

  10.1021/ja01290a044

文献信息

• Trichloroisocyanuric acid as an efficient homogeneous catalyst for the chemoselective synthesis of 2-substituted oxazolines, imidazolines and thiazolines under solvent-free condition
  作者：Fatemeh Hojati、Atefe Nezhadhoseiny

  DOI：10.2298/jsc111031028h

  日期：——

  Trichloroisocyanuric acid, as a commercially available and inexpen- sive catalyst, was used in a new, facile and efficient procedure for the synthesis of 2-oxazolines, 2-imidazolines and 2-thiazolines through the reaction of nitriles with 2-aminoethanol, ethylenediamine or 2-aminoethanеthiol under solvent-free conditions.

  三氯异氰尿酸是一种市售的廉价催化剂，它通过腈与2-氨基乙醇，乙二胺或乙腈的反应，以新颖，便捷，高效的方法合成了2-恶唑啉，2-咪唑啉和2-噻唑啉。在无溶剂条件下的2-氨基乙硫醇。
• Easy access to thiazolines and thiazines via tandem S-alkylation-cyclodeamination of thioamides/haloamines
  作者：Uma Pathak、Shubhankar Bhattacharyya、Vishwanath Dhruwansh、Lokesh Kumar Pandey、Rekha Tank、Malladi V. S. Suryanarayana

  DOI：10.1039/c1gc15285h

  日期：——

  This is the first report of a facile synthesis of thiazolines and thiazines from a self-catalyzed, water assisted tandem S-alkylation-cyclodeamination reaction of thioamides/haloamines. The reaction is clean and efficient with simple product work-up, and is applicable to a variety of substrates.

  这是首次报道通过硫代酰胺/卤胺的自催化、水辅助串联 S-烷基化-环脱氨基反应简便合成噻唑啉类和噻嗪类化合物。该反应清洁高效，产物处理简单，适用于多种底物。
• Tribromomelamine: A Novel and Efficient Catalyst for the Synthesis 2-Arylthiazolines under Solvent-free Conditions
  作者：Liqiang Wu

  DOI：10.1155/2012/972109

  日期：——

  A novel procedure for the synthesis of 2-arylthiazolines through one-pot condensation of of nitriles with 2-aminoethanethiol in the presence of tribromomelamine as catalyst under solvent-free conditions is described.

  描述了一种新颖的程序，通过在无溶剂条件下使用三溴三嗪作为催化剂，在腈和2-氨基乙硫醇的一锅缩合反应中合成2-芳基噻唑啉。
• One-Pot Synthesis of 2-Arylthiazolines with 1-Butyl-3-Methylimidazolium Tribromide as a Catalytic Reagent
  作者：Guangzhou Lu、Limin Yang、Liqiang Wu

  DOI：10.1080/10426507.2011.618816

  日期：2012.3.1

  simple, inexpensive, and efficient one-pot synthesis of 2-arylthiazoline derivatives under solvent-free conditions using a catalytic amount of 1-butyl-3-methylimidazolium tribromide with excellent product yields is reported. This methodology provides easy, quantitative access to various 2-arylthiazoline derivatives, using environmentally benign 1-butyl-3-methylimidazolium tribromide as a catalyst. GRAPHICAL

  摘要 报道了使用催化量的 1-丁基-3-甲基咪唑鎓三溴化物在无溶剂条件下简单、廉价、高效地一锅法合成 2-芳基噻唑啉衍生物，并具有优异的产品收率。该方法使用环境友好的三溴化 1-丁基-3-甲基咪唑鎓作为催化剂，可以轻松、定量地获取各种 2-芳基噻唑啉衍生物。图形概要
• A Single-Reagent-Driven Multistep One-Pot Preparation of Thiazolines and 1,3-Thiazines from Aldoximes, Nitriles, and Carboxylic­ Acids
  作者：Uma Pathak、Shubhankar Bhattacharyya

  DOI：10.1055/s-0035-1560459

  日期：——

  N-(omega-Bromoalkyl)dichlorothiophosphoramidates have been designed as a new class of reagent for the single-reagent-driven multistep preparation of 2-substituted thiazolines and 1,3-thiazines from aldoximes, nitriles, or carboxylic acids. A wide range of substrates both aromatic as well as aliphatic were investigated and found suitable for the developed protocol.