N,N'-bis{(E)-[4-(dimethylamino)phenyl]methylidene}benzene-1,2-diamine | 15223-27-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N'-bis{(E)-[4-(dimethylamino)phenyl]methylidene}benzene-1,2-diamine
• 英文别名: 4-[[2-[[4-(dimethylamino)phenyl]methylideneamino]phenyl]iminomethyl]-N,N-dimethylaniline
• CAS: 15223-27-5
• 化学式: C₂₄H₂₆N₄
• 分子量: 370.497
• InChiKey: YVDRPYNZZVLTDC-UHFFFAOYSA-N

物化性质

• 熔点：
  179 °C
• 沸点：
  577.8±45.0 °C(Predicted)
• 密度：
  1.02±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  31.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N,N'-bis{(E)-[4-(dimethylamino)phenyl]methylidene}benzene-1,2-diamine 在 甲醇 、 sodium tetrahydroborate 作用下， 反应 0.25h， 生成
  参考文献：
  名称：

  [EN] FBXO3 INHIBITORS
  [FR] INHIBITEURS DE FBXO-3

  摘要：

  本申请公开了苯扎托品及相关化合物及其作为FBXO-3抑制剂的应用。

  公开号：

  WO2013184202A1
• 作为产物：
  描述：

  邻苯二胺 、 对二甲氨基苯甲醛 以 乙醇 为溶剂， 反应 0.5h， 生成 N,N'-bis{(E)-[4-(dimethylamino)phenyl]methylidene}benzene-1,2-diamine
  参考文献：
  名称：

  [EN] FBXO3 INHIBITORS
  [FR] INHIBITEURS DE FBXO-3

  摘要：

  本申请公开了苯扎托品及相关化合物及其作为FBXO-3抑制剂的应用。

  公开号：

  WO2013184202A1

文献信息

• γ-Maghemite-silica nanocomposite: A green catalyst for diverse aromatic N-heterocycles
  作者：Pranab Ghosh、Amitava Mandal、Raju Subba

  DOI：10.1016/j.catcom.2013.06.026

  日期：2013.11

  gamma-Maghemite-silica nanocomposite has been applied as a green catalyst to synthesize variety of aromatic N-heterocycles under solvent free conditions. Characterization was done by modern analytical tools (UV, IR, AAS, DSC, EDXRF, powdered XRD, EPR, Mossbauer and TEM). Mild reaction conditions and recyclability have made the present protocol both environmentally and economically viable. (c) 2013 Elsevier B.V. All rights reserved.
• El-Samahy, A. A.; Abdel-Mawgoud, A. M.; Gharib, E. A. Abou, Bulletin de la Societe Chimique de France, 1984, vol. I, p. 175 - 179
  作者：El-Samahy, A. A.、Abdel-Mawgoud, A. M.、Gharib, E. A. Abou、Ismail, N. M.

  DOI：——

  日期：——
• DNA interaction and efficient antimicrobial activities of 4N chelating metal complexes
  作者：S. Packianathan、T. Arun、N. Raman

  DOI：10.1016/j.jphotobiol.2015.04.006

  日期：2015.7

  A new series of metal(II) complexes using a symmetric Schiff base ligand, obtained by the condensation reaction of 4-formyl-N,N-dimethylaniline with benzene-1,2-diamine were synthesized and characterized. The various physico-chemical data indicate that the complexes have octahedral geometry. The intrinsic binding constant of the complexes with DNA is explored. The UV-Vis., circular dichorism, fluorescence emission spectral data and the viscosity measurements indicate that the complexes bind to calf thymus DNA (CT DNA) by intercalative mode. The intrinsic binding constants of Cu(II), Ni(II), Co(II) and Zn(II) complexes are found to be 7.1 x 10(4), 5.2 x 10(4), 1.8 x 10(5) and 6.3 x 10(4) M-1, respectively. The cleavage studies of these complexes are investigated by gel electrophoresis method in the presence of peroxide. The complexes exhibit enhanced biological activities compared to the free ligand. (C) 2015 Elsevier B.V. All rights reserved.
• Characterization studies of some bi- and tetradentate bifunctionalSchiff base complexes with Co(II), Ni(II), and Cu(II)
  作者：M. R. Mahmoud、S. A. Ibrahim、N. M. Ismail

  DOI：10.1007/bf00798452

  日期：1985.2
• [EN] FBXO3 INHIBITORS<br/>[FR] INHIBITEURS DE FBXO-3
  申请人：UNIV PITTSBURGH

  公开号：WO2013184202A1

  公开（公告）日：2013-12-12

  The present application discloses benzathine and related compounds and their use as FBXO-3 inhibitors.

  本申请公开了苯扎托品及相关化合物及其作为FBXO-3抑制剂的应用。