A-nor-5β-cholestan-3-one | 6908-01-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: A-nor-5β-cholestan-3-one
• 英文别名: A-Nor-5β-cholestan-3-on
• CAS: 6908-01-6
• 化学式: C₂₆H₄₄O
• 分子量: 372.635
• InChiKey: SEFOZCSMZRYPSN-RZAJJJKESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.29
• 重原子数：
  27.0
• 可旋转键数：
  5.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  17.07
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  A-nor-5β-cholestan-3-one 在 lithium aluminium tetrahydride 、 乙醚 作用下， 生成 A-nor-5β-cholestan-3β-ol
  参考文献：
  名称：

  62. Steriods和瓦尔登反演。第XLI部分。某些A-nor-，B-nor-和17-氨基类固醇的脱氨基

  摘要：

  DOI：

  10.1039/jr9590000345
• 作为产物：
  描述：

  7-oxo-3,4-seco-cholestene-(5)-dioic acid-(3,4) 在 盐酸 、 amalgamated zinc 、 乙酸酐 、 溶剂黄146 作用下， 生成 A-nor-5β-cholestan-3-one
  参考文献：
  名称：

  Auditory Model Enhances Relative-Timing Learning

  摘要：

  In recent experiments (Q. Lai, C. H. Shea, & M. Little, 2000; C. H. Shea, G. Wulf, J. Park, & B. Gaunt, 2001), auditory models were found to be effective in enhancing relative-timing performance and learning in constant practice conditions. In the present experiment, the authors examined (a) whether an auditory model also enhances relative-timing learning in blocked and random practice conditions and (b) whether experience with the auditory model enhances participants' ability to produce the response by using different effector sequences. Participants (N = 48) were randomly assigned to 1 of 4 acquisition conditions in which an auditory model was or was not present and the practice schedule was blocked or random. In the acquisition phase, all participants alternately pressed 2 keys on a keyboard in an attempt to match 5 goal intervals. In the auditory model conditions, a sequence of tones was played before each acquisition trial. The tones represented the correct timing sequence for that trial. One retention and 3 effector-transfer tests without feedback were administered about 24 hr after the completion of acquisition. The results indicated that the auditory model enhanced relative-timing performance and learning independently of practice schedule. In addition, the auditory model enhanced relative timing on the effector-transfer tests, but absolute-timing performance and learning were not affected by the auditory model. Thus, relative timing was found to be effector independent but absolute timing was not.

  DOI：

  10.1080/00222890209601948

文献信息

• The contraction of ring a in 5α-cholestane derivatives
  作者：B. Fuchs、H.J.E. Loewenthal

  DOI：10.1016/0040-4020(60)80070-1

  日期：1960.1

  The β-keto-ester which is obtained by Dieckmann cyclization of the dimethyl ester (I) of the dicarboxylic acid obtained by oxidative opening of ring A in 5α-cholestan-3-one and related compounds has been shown to have the structure IIa, by its degradation, via the unsaturated acid (Va), to A-nor-5β-cholestan-3-one (VI) and to the dimethyl ester (VIIb). The stereochemistry of compound IIa and of related

  通过对5α-胆甾烷-3-酮中的环A氧化开环而获得的二元羧酸的二甲酯（I）进行Dieckmann环化反应获得的β-酮酯已显示具有结构IIa，通过不饱和酸（Va）降解为A-nor-5β-胆甾烷-3-酮（VI）和二甲酯（VIIb）。讨论了化合物IIa和相关的A-取代的A-nor-5α-胆甾烷的立体化学。从5α-胆甾-1-烯-3-酮（XIV）开始，合成了α-nor-5α-胆甾醇-1-酮（XVIIb）。
• 478. Steroids. Part III. 3-Methyl-A-norcholest-3(5)-ene
  作者：C. W. Shoppee、G. H. R. Summers

  DOI：10.1039/jr9520002528

  日期：——
• Pete,J.-P.; Viriot-Villaume,M.-L., Bulletin de la Societe Chimique de France, 1971, p. 3699 - 3709
  作者：Pete,J.-P.、Viriot-Villaume,M.-L.

  DOI：——

  日期：——
• Barton, Derek H. R.; Boivin, Jean; Lelandais, Patrick, Journal of the Chemical Society. Perkin transactions I, 1989, p. 463 - 468
  作者：Barton, Derek H. R.、Boivin, Jean、Lelandais, Patrick

  DOI：——

  日期：——
• 4-Substituted Steroids¹
  作者：Norman W. Atwater

  DOI：10.1021/ja01496a044

  日期：1960.6