N-(9-fluorenylmethoxycarbonyl)-β-alanine p-nitrophenyl ester | 176755-93-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: N-(9-fluorenylmethoxycarbonyl)-β-alanine p-nitrophenyl ester
• 英文别名: (4-nitrophenyl) 3-(9H-fluoren-9-ylmethoxycarbonylamino)propanoate
• CAS: 176755-93-4
• 化学式: C₂₄H₂₀N₂O₆
• 分子量: 432.433
• InChiKey: DEXBXJZYWDEUPC-UHFFFAOYSA-N

物化性质

• 沸点：
  658.7±45.0 °C(Predicted)
• 密度：
  1.330±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  32
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  110
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N-(9-fluorenylmethoxycarbonyl)-β-alanine p-nitrophenyl ester 在 咪唑 作用下， 以 1,4-二氧六环 为溶剂， 反应 24.0h， 生成 1-(N,N-diisopropylamido)-β-cyanoethylphosphite of 3-dimethoxytrityloxy-2-<amino>propanol
  参考文献：
  名称：

  Antsypovich, S. I.; Volkov, E. M.; Oretskaya, T. S., Russian Journal of Bioorganic Chemistry, 1995, vol. 21, # 10, p. 669 - 674

  摘要：

  DOI：
• 作为产物：
  描述：

  9-芴甲基-N-琥珀酰亚胺基碳酸酯 在 三乙胺 、 N,N'-二环己基碳二亚胺 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 24.5h， 生成 N-(9-fluorenylmethoxycarbonyl)-β-alanine p-nitrophenyl ester
  参考文献：
  名称：

  Synthesis of Modified Oligonucleotides and Production of Duplexes With Covalently Linked Chains

  摘要：

  A method has been devised to synthesize a DNA-duplex with covalently connected strands. Primary amino group located on one strand is linked to a carboxyl group of the other strand through the agency of a water soluble carbodiimide condensing agent. Conditions for the reaction between chains of a duplex composed of the modified oligonucleotides [1] were optimized. The thermal and hydrolytic stability of the cross linked duplex was examined.

  DOI：

  10.1080/07328319608002138

文献信息

• US6187913B1
  申请人：——

  公开号：US6187913B1

  公开（公告）日：2001-02-13
• Antsypovich, S. I.; Volkov, E. M.; Oretskaya, T. S., Russian Journal of Bioorganic Chemistry, 1995, vol. 21, # 10, p. 669 - 674
  作者：Antsypovich, S. I.、Volkov, E. M.、Oretskaya, T. S.、Romanova, E. A.、Tashlitskii, V. N.、et al.

  DOI：——

  日期：——
• Synthesis of Modified Oligonucleotides and Production of Duplexes With Covalently Linked Chains
  作者：S. I. Antsypovich、T. S. Oretskaya、E. M. Volkov、E. A. Romanova、V. N. Tashlitsky、M. Blumenfeld、Z. A. Shabarova

  DOI：10.1080/07328319608002138

  日期：1996.4

  A method has been devised to synthesize a DNA-duplex with covalently connected strands. Primary amino group located on one strand is linked to a carboxyl group of the other strand through the agency of a water soluble carbodiimide condensing agent. Conditions for the reaction between chains of a duplex composed of the modified oligonucleotides [1] were optimized. The thermal and hydrolytic stability of the cross linked duplex was examined.