1-cyclopropylmethyl-4-[2-(3,3,5,5-tetramethylcyclohexyl)phenyl]piperazine | 859217-52-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-cyclopropylmethyl-4-[2-(3,3,5,5-tetramethylcyclohexyl)phenyl]piperazine
• 英文别名: Milategrast；1-(cyclopropylmethyl)-4-[2-(3,3,5,5-tetramethylcyclohexyl)phenyl]piperazine
• CAS: 859217-52-0
• 化学式: C₂₄H₃₈N₂
• 分子量: 354.579
• InChiKey: PGWIKFFLIJECAM-UHFFFAOYSA-N

物化性质

• 沸点：
  441.4±45.0 °C(Predicted)
• 密度：
  0.991±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

制备方法与用途

Milategrast 可用作细胞粘附抑制剂或细胞浸润抑制剂。体外实验显示，Milategrast 能有效抑制 Jurkat 细胞与人纤维连接蛋白的黏附，其 IC50 值小于 5 μM。

反应信息

• 作为反应物：
  描述：

  1-cyclopropylmethyl-4-[2-(3,3,5,5-tetramethylcyclohexyl)phenyl]piperazine 在 氢溴酸 作用下， 以 甲醇 、 水 为溶剂， 生成 1-cyclopropylmethyl-4-[2-(3,3,5,5-tetramethylcyclohexyl)phenyl]piperazine hydrobromide
  参考文献：
  名称：

  WO2006/68058

  摘要：

  公开号：
• 作为产物：
  描述：

  在 溶剂黄146 sodium tetrahydroborate 、 sodium hydroxide 、 水 作用下， 以 四氢呋喃 、 甲基叔丁基醚 为溶剂， 反应 2.7h， 生成 1-cyclopropylmethyl-4-[2-(3,3,5,5-tetramethylcyclohexyl)phenyl]piperazine
  参考文献：
  名称：

  WO2006/68058

  摘要：

  公开号：

文献信息

• 1,2-Di(cyclic)substituted benzene compounds
  申请人：Kawahara Tetsuya

  公开号：US20050261291A1

  公开（公告）日：2005-11-24

  In one aspect, the present invention provides compounds having formula (1) or (100), a salt thereof or a hydrate of the foregoing, which compounds exhibit excellent cell adhesion inhibitory action or cell infiltration inhibitory action, and are useful as therapeutic or prophylactic agents for various inflammatory diseases and autoimmune diseases associated with adhesion and infiltration of leukocytes, such as inflammatory bowel disease (particularly ulcerative colitis or Crohn's disease), irritable bowel syndrome; rheumatoid arthritis, psoriasis, multiple sclerosis, asthma and atopic dermatitis. wherein R10 represents optionally substituted cycloalkyl, etc., R20-23 represent hydrogen, alkyl, alkoxy, etc., R30-32 represent hydrogen, alkyl, oxo, etc., and R40 represents optionally substituted alkyl, etc.

  在一个方面，本发明提供具有式（1）或（100）的化合物，其盐或前述的水合物，这些化合物表现出优异的细胞粘附抑制作用或细胞浸润抑制作用，并且可用作治疗或预防与白细胞粘附和浸润相关的各种炎症性疾病和自身免疫疾病的药物，例如炎症性肠病（尤其是溃疡性结肠炎或克罗恩病）、肠易激综合征；类风湿性关节炎、牛皮癣、多发性硬化、哮喘和特应性皮炎。 其中R10代表可选择地取代的环烷基等，R20-23代表氢、烷基、烷氧基等，R30-32代表氢、烷基、氧代基等，R40代表可选择地取代的烷基等。
• 1,2-di(cyclic)substituted benzene compounds
  申请人：Kawahara Tetsuya

  公开号：US20070112002A1

  公开（公告）日：2007-05-17

  A compound represented by the following general formula (1) or (100), a salt thereof or a hydrate of the foregoing has excellent cell adhesion inhibitory action or cell infiltration inhibitory action, and is useful as a therapeutic or prophylactic agent for various inflammatory diseases and autoimmune diseases associated with adhesion and infiltration of leukocytes, such as inflammatory bowel disease (particularly ulcerative colitis or Crohn's disease), irritable bowel syndrome, rheumatoid arthritis, psoriasis, multiple sclerosis, asthma and atopic dermatitis. wherein R10 represents optionally substituted cycloalkyl, etc., R20-23 represent hydrogen, alkyl, alkoxy, etc., R30-32 represent hydrogen, alkyl, oxo, etc., and R40 represents optionally substituted alkyl, etc.

  以下通式（1）或（100）所代表的化合物、其盐或其水合物具有优异的细胞黏附抑制作用或细胞浸润抑制作用，可用作治疗或预防与白细胞黏附和浸润有关的各种炎症性疾病和自身免疫性疾病，如炎症性肠病（尤其是溃疡性结肠炎或克罗恩病）、肠易激综合征、类风湿关节炎、银屑病、多发性硬化症、哮喘和特应性皮炎等。其中，R10代表可选取代的环烷基等，R20-23代表氢、烷基、烷氧基等，R30-32代表氢、烷基、氧代、等，R40代表可选取代的烷基等。
• 1,2-di(cyclic) substituted benzene compounds
  申请人：Kawahara Tetsuya

  公开号：US20060276465A1

  公开（公告）日：2006-12-07

  A compound represented by the following general formula (1) or (100), a salt thereof or a hydrate of the foregoing has excellent cell adhesion inhibitory action or cell infiltration inhibitory action, and is useful as a therapeutic or prophylactic agent for various inflammatory diseases and autoimmune diseases associated with adhesion and infiltration of leukocytes, such as inflammatory bowel disease (particularly ulcerative colitis or Crohn's disease), irritable bowel syndrome, rheumatoid arthritis, psoriasis, multiple sclerosis, asthma and atopic dermatitis. wherein R 10 represents optionally substituted cycloalkyl, etc., R 20-23 represent hydrogen, alkyl, alkoxy, etc., R 30-32 represent hydrogen, alkyl, oxo, etc., and R40 represents optionally substituted alkyl, etc. And A compound represented by the following general formula (1) or (100), a salt thereof or a hydrate of the foregoing has excellent cell adhesion inhibitory action or cell infiltration inhibitory action, and is useful as a therapeutic or prophylactic agent for various inflammatory diseases and autoimmune diseases associated with adhesion and infiltration of leukocytes, such as inflammatory bowel disease (particularly ulcerative colitis or Crohn's disease), irritable bowel syndrome, rheumatoid arthritis, psoriasis, multiple sclerosis, asthma and atopic dermatitis. wherein R 10 represents 5- to 10-membered cycloalkyl etc. optionally substituted with hydroxyl etc., R 30 , R 31 and R 32 may be the same or different and each represents hydrogen etc., R 40 represents C1-10 alkyl etc. optionally substituted with hydroxyl etc., n represents an integer of 0, 1 or 2, X 1 represents CH or nitrogen, and R 20 , R 21 , R 22 and R 23 may be the same or different and each represents hydrogen etc.

  以下通式（1）或（100）所代表的化合物，其盐或水合物，具有优良的细胞黏附抑制作用或细胞浸润抑制作用，可用作治疗或预防与白细胞黏附和浸润相关的各种炎症性疾病和自身免疫疾病的药物，例如炎症性肠病（特别是溃疡性结肠炎或克罗恩病）、肠易激综合症、类风湿性关节炎、牛皮癣、多发性硬化症、哮喘和特应性皮炎。其中，R10表示可选取代的环烷基等，R20-23表示氢、烷基、烷氧基等，R30-32表示氢、烷基、氧代等，R40表示可选取代的烷基等。另外，以下通式（1）或（100）所代表的化合物，其盐或水合物，具有优良的细胞黏附抑制作用或细胞浸润抑制作用，可用作治疗或预防与白细胞黏附和浸润相关的各种炎症性疾病和自身免疫疾病的药物，例如炎症性肠病（特别是溃疡性结肠炎或克罗恩病）、肠易激综合症、类风湿性关节炎、牛皮癣、多发性硬化症、哮喘和特应性皮炎。其中，R10表示5-到10-成员环烷基等，可选取代为羟基等，R30、R31和R32可以相同也可以不同，每个表示氢等，R40表示可选取代的C1-10烷基等，可选取代为羟基等，n表示0、1或2，X1表示CH或氮，R20、R21、R22和R23可以相同也可以不同，每个表示氢等。
• 1,2-di(cyclic) substituted benzene derivatives
  申请人：Kawahara Tetsuya

  公开号：US20060281747A1

  公开（公告）日：2006-12-14

  A compound represented by the following general formula (1) or (100), a salt thereof or a hydrate of the foregoing has excellent cell adhesion inhibitory action and cell infiltration inhibitory action. wherein R 10 represents 5- to 10-membered cycloalkyl etc. optionally substituted with hydroxyl etc., R 30 , R 31 and R 32 may be the same or different and each represents hydrogen etc., R 40 represents C1-10 alkyl etc. optionally substituted with hydroxyl etc., n represents an integer of 0, 1 or 2, X 1 represents CH or nitrogen, and R 20 , R 21 , R 22 and R 23 may be the same or different and each represents hydrogen etc.

  下列通式（1）或（100）所代表的化合物、其盐或其水合物具有优异的细胞粘附抑制作用和细胞渗透抑制作用。其中，R10代表5-至10-成员的环烷基等，可选地取代羟基等；R30、R31和R32可以相同也可以不同，且每个代表氢原子等；R40代表C1-10烷基等，可选地取代羟基等；n代表0、1或2的整数；X1代表CH或氮原子；R20、R21、R22和R23可以相同也可以不同，且每个代表氢原子等。
• Crystal and Salt of 1-Cyclopropylmethyl-4-[2-(3,3,5,5-Tetramethylcyclohexyl)Phenyl]Piperazine
  申请人：Kotake Makoto

  公开号：US20080161566A1

  公开（公告）日：2008-07-03

  Salts and crystals of 1-cyclopropylmethyl-4-[2-(3,3,5,5-tetramethylcyclohexyl)phenyl]piperazine have excellent cell adhesion inhibitory action and cell infiltration inhibitory action, and are useful as therapeutic or prophylactic agents for various inflammatory diseases and autoimmune diseases associated with adhesion and infiltration of leukocytes, such as inflammatory bowel disease (particularly ulcerative colitis or Crohn's disease), irritable bowel syndrome, rheumatoid arthritis, psoriasis, multiple sclerosis, asthma and atopic dermatitis.

  1-环丙基甲基-4-[2-(3,3,5,5-四甲基环己基)苯基]哌嗪的盐和晶体具有极好的细胞黏附抑制作用和细胞浸润抑制作用，可用作治疗或预防与白细胞黏附和浸润有关的各种炎症性疾病和自身免疫性疾病的药物，例如炎症性肠病（尤其是溃疡性结肠炎或克罗恩病）、肠易激综合征、类风湿性关节炎、银屑病、多发性硬化症、哮喘和特应性皮炎。