4-氯癸烷 | 999-49-5

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氯化物
• 中文名称: 4-氯癸烷
• 英文名称: 4-Chlor-decan
• 英文别名: 4-chlorodecane
• CAS: 999-49-5
• 化学式: C₁₀H₂₁Cl
• 分子量: 176.73
• InChiKey: SFSRUCSICQYPSN-UHFFFAOYSA-N

物化性质

• 沸点：
  110 °C(Press: 30 Torr)
• 密度：
  0.860±0.06 g/cm3(Predicted)
• 保留指数：
  1200

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  11
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  1-氯癸烷 、 2-氯癸烷 、 3-氯癸烷 、 4-氯癸烷 生成 2-decyl acetate
  参考文献：
  名称：

  DENO N. C.; GLADFELTER E. J.; POHL D. G., J. ORG. CHEM., 1979, 44, NO 21, 3728-3729

  摘要：

  DOI：
• 作为产物：
  描述：

  4-正癸醇 在 四氯化碳 、 三苯基膦 作用下， 反应 24.0h， 生成 4-氯癸烷
  参考文献：
  名称：

  澄清基于芳基磺酸盐的亲核助剂离去基团的亲核取代的立体化学过程

  摘要：

  当在丙酮中用卤化锂在回流下处理时，被修饰为对甲苯磺酸盐，PEG-磺酸盐或对甲苯磺酸盐的仲醇在反应中心发生构型转化，其中PEG-磺酸盐和对甲苯磺酸盐的反应性更高。在空间受限的情况下，淘汰是一个相互竞争的过程。相反，当用TiCl 4处理时，简单的仲磺酸盐使氯化物产物的构型部分反转。在这些条件下，在给定的烷基磺酸盐底物中观察到的任何构型保留都可能是由于相邻基团的参与或对碳正离子（或离子对）的非对映选择性攻击，而不是S N i机理。

  DOI：

  10.1021/jo900991z

文献信息

• Arylsulfonate-Based Nucleophile Assisting Leaving Groups
  作者：Salvatore D. Lepore、Anjan K. Bhunia、Pamela Cohn

  DOI：10.1021/jo051241y

  日期：2005.9.1

  synthesis and unique reactivity of a series of arylsulfonate-based nucleophile assisting leaving groups (NALG) containing oligomeric ether units (including crown ethers) attached to the arylsulfonyl ring in the ortho orientation are described. The reactions of a variety of these ether-containing alkyl sulfonates with metal halides proceeded at substantially greater rates than electronically similar

  描述了一系列基于芳基磺酸盐的亲核试剂的合成和独特的反应性，该亲核试剂有助于在邻位方向上连接至芳基磺酰基环的含低聚醚单元（包括冠醚）的离去基团（NALG）。各种这些含醚的烷基磺酸盐与金属卤化物的反应比电子类似的磺酸盐的反应速率大得多。在亲核取代反应中，相对于相应的钠盐和钾盐，这些含醚的离去基团还显示出对卤化锂的显着选择性。
• Nucleophile Leaving Groups
  申请人：Lepore Salvatore

  公开号：US20080221347A1

  公开（公告）日：2008-09-11

  Sulfonate leaving groups include a cation chelating moiety, e.g. a polyether or crown ether. The chelating moiety stabilizes the sulfonate leaving group by forming a complex with a cation of a cation-nucleophile combination. The stabilized leaving group is more easily displaced under many conditions than are standard arylsulfonate leaving groups such as the toxyl group. The chelating moiety also favors certain cations depending on the identity of the moiety thereby enhancing the reaction rate with nucleophilic salts containing the preferred cation. Use of the inventive leaving groups results in improved yields, decreased reaction times and improved product purity.

  磺酸离去基团包括一个阳离子螯合基团，例如聚醚或冠醚。螯合基团通过与阳离子-亲核物质的阳离子形成复合物来稳定磺酸离去基团。稳定的离去基团在许多条件下比标准的芳基磺酸离去基团（如toxyl基团）更容易被取代。螯合基团还根据其身份证明有利于某些阳离子，从而增强了与含有优选阳离子的亲核盐的反应速率。使用这种创新的离去基团可以提高产率，缩短反应时间并提高产品纯度。
• Fluoroalkoxy amino triazines for control of weeds in sugar beets
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0336587A1

  公开（公告）日：1989-10-11

  Compounds of the formula wherein R is C₁-C₄ alkyl, CH₂CH=CH₂, CH₂C≡CH, cyclopropylmethyl or CH₂CH₂R₂; R₁ is C₁-C₂ alkyl, C₁-C₂ haloalkyl, CH₂CN, CH₂OCH₃, C₁-C₃ alkoxy, C₁-C₃ alkylthio, phenylthio or NR₃R₄; R₂ is C₁-C₂ alkoxy, C₁-C₂ alkylthio, CN or halogen; R₃ and R₄ are independently H or CH₃; and X is NHCH₃, N(CH₃)₂ or N(CH₃)OCH₃; provided that when R₁ is OCH₂CH₃ or CH₂OCH₃, then R is other than CH₃; and their agriculturally suitable salts. exhibit herbicidal activity. They have particular utility for the selective control of weeds in beet.

  式中的化合物 其中 R 是 C₁-C₄ 烷基、CH₂CH=CH₂、CH₂C≡CH、环丙基甲基或 CH₂CH₂R₂； R₁ 是 C₁-C₂ 烷基、C₁-C₂ 卤代烷基、CH₂CN、CH₂OCH₃、C₁-C₃ 烷氧基、C₁-C₃ 烷硫基、苯硫基或 NR₃R₄； R₂ 是 C₁-C₂烷氧基、C₁-C₂烷硫基、CN 或卤素； R₃ 和 R₄ 独立地为 H 或 CH₃；以及 X 是 NHCH₃、N(CH₃)₂ 或 N(CH₃)OCH₃ ； 但当 R₁ 是 OCH₂CH₃ 或 CH₂OCH₃ 时，R 不是 CH₃； 以及它们在农业上适用的盐类具有除草活性。它们特别适用于选择性控制甜菜中的杂草。
• Indium-Catalyzed Direct Chlorination of Alcohols Using Chlorodimethylsilane−Benzil as a Selective and Mild System
  作者：Makoto Yasuda、Satoshi Yamasaki、Yoshiyuki Onishi、Akio Baba

  DOI：10.1021/ja048688t

  日期：2004.6.1

  The InCl3-catalyzed reaction of alcohols with chlorodimethylsilane (HSiMe2Cl) in the presence of benzil gave the corresponding organic chlorides under mild conditions. Benzil significantly changes the reaction course because the reducing product through dehydroxyhydration was obtained in the absence of benzil. The secondary or tertiary alcohols were effectively chlorinated. The substrates bearing acid-sensitive functional groups were also applied to this system. The highly selective chlorination of the tertiary site was observed in the competitive reaction between tertiary and primary alcohols. The highly coordinated hydrosilane generated from benzil and HSiMe2Cl is an important intermediate.
• Exact and approximate sum representations for the Dirichlet process
  作者：Hemant Ishwaran、Mahmoud Zarepour

  DOI：10.2307/3315951

  日期：2002.6

  AbstractThe Dirichlet process can be regarded as a random probability measure for which the authors examine various sum representations. They consider in particular the gamma process construction of Ferguson (1973) and the “stick‐breaking” construction of Sethuraman (1994). They propose a Dirichlet finite sum representation that strongly approximates the Dirichlet process. They assess the accuracy of this approximation and characterize the posterior that this new prior leads to in the context of Bayesian nonpara‐metric hierarchical models.