6-bromohexanoyl-p-nitrophenylester | 135249-11-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: 6-bromohexanoyl-p-nitrophenylester
• 英文别名: 4-nitrophenyl 6-bromohexanoate；6-Bromohexanoic acid, 4-nitrophenyl ester；(4-nitrophenyl) 6-bromohexanoate
• CAS: 135249-11-5
• 化学式: C₁₂H₁₄BrNO₄
• 分子量: 316.151
• InChiKey: IGFDRPHVXMUTLG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  72.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-bromohexanoyl-p-nitrophenylester 在 silver nitrate 作用下， 以 乙腈 为溶剂， 以97.6%的产率得到4-nitrophenyl 6-(nitrooxy)hexanoate
  参考文献：
  名称：

  NITRIC OXIDE DONATING DERIVATIVES OF FLUPROSTENOL

  摘要：

  本发明涉及15-硝氧基丙烯酸氟前列醇衍生物，其用于治疗青光眼和眼压增高，以及含有15-硝氧基丙烯酸氟前列醇衍生物的配方。

  公开号：

  US20180118677A1
• 作为产物：
  描述：

  对硝基苯酚 、 6-溴己酸 在 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 以80.3%的产率得到6-bromohexanoyl-p-nitrophenylester
  参考文献：
  名称：

  NITRIC OXIDE DONATING DERIVATIVES OF FLUPROSTENOL

  摘要：

  本发明涉及15-硝氧基丙烯酸氟前列醇衍生物，其用于治疗青光眼和眼压增高，以及含有15-硝氧基丙烯酸氟前列醇衍生物的配方。

  公开号：

  US20180118677A1

文献信息

• [EN] NITRIC OXIDE DONATING CARNOSINE COMPOUNDS<br/>[FR] COMPOSÉS DE CARNOSINE DONNEURS D'OXYDE NITRIQUE
  申请人：NICOX SCIENCE IRELAND

  公开号：WO2016034619A1

  公开（公告）日：2016-03-10

  The present invention relates to nitric oxide donor carnosine derivatives having a great efficacy in reducing elevated intraocular pressure, to processes for their preparation and to their use in the treatment and/or prophylaxis of glaucoma and ocular hypertension.

  本发明涉及一种在降低升高的眼压方面具有很高效果的一氧化氮供体肌肽衍生物，涉及它们的制备过程以及它们在青光眼和眼压增高的治疗和/或预防中的应用。
• Nitric oxide donating carnosine compounds
  申请人：Nicox Science Ireland

  公开号：EP2993172A1

  公开（公告）日：2016-03-09

  The present invention relates to nitric oxide donor carnosine derivatives having a great efficacy in reducing elevated intraocular pressure, to processes for their preparation and to their use in the treatment and/or prophylaxis of glaucoma and ocular hypertension.

  本发明涉及一氧化氮供体肉碱衍生物，该衍生物在降低眼压升高方面具有显著功效，还涉及其制备工艺及其在治疗和/或预防青光眼和眼压升高方面的用途。
• Nitric oxide donating derivatives of fluprostenol
  申请人：NICOX S.A.

  公开号：US10280138B2

  公开（公告）日：2019-05-07

  The present invention relates to 15-nitrooxyderivatives of fluprostenol, their use for the treatment of glaucoma and ocular hypertension and formulation containing 15-nitrooxy derivatives of fluprostenol.

  本发明涉及氟前列醇的 15-硝基氧基衍生物、它们在治疗青光眼和眼压过高方面的用途以及含有氟前列醇的 15-硝基氧基衍生物的制剂。
• Solid-phase preparation of 5′,3′-heterobifunctional oligodeoxyribonucleotides using modified solid supports
  作者：Ulysse Asseline、Edwige Bonfils、Robin Kurfürst、Marcel Chassignol、Victoria Roig、Nguyen Thanh Thuong

  DOI：10.1016/s0040-4020(01)90786-0

  日期：1992.1

  The solid-phase preparation of oligodeoxyribonucleotides attached to intercalator or reactive groups through their 5'- and (or) 3'-ends is reported. These syntheses implicate the introduction of suitable masked functional groups at the 5'-end of the oligonucleotide by the intermediate of their phosphoramidite derivatives or at the 3'-end of the oligonucleotide using modified solid supports. After full deblocking, the functional groups (phosphate, thiophosphate, primary amine or thiol) can be reacted with the suitable reactive group involved in the chosen ligand. These methods allow the preparation of heterobifunctional derivatized oligodeoxyribonucleotides.
• Organocatalytic Activation of Alkylacetic Esters as Enolate Precursors to React with α,β-Unsaturated Imines
  作者：Lin Hao、Shaojin Chen、Jianfeng Xu、Bhoopendra Tiwari、Zhenqian Fu、Tong Li、Jieyan Lim、Yonggui Robin Chi

  DOI：10.1021/ol4021805

  日期：2013.10.4

  Asymmetric functionalization of alkylacetic esters and their derivatives is traditionally achieved via preformed enolates with chiral auxiliaries. Catalytic versions of such transformations are attractive but challenging. A direct catalytic activation of simple alkylacetic esters via N-heterocyclic carbene organocatalysts to generate chiral enolate intermediates for highly enantioselective reactions is reported.